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Scientific paper - Original scientific paper
Value of rapid aetiological diagnosis in optimization of antimicrobial treatment in bacterial community acquired pneumonia
Collegium Antropologicum, 36 (2012), 2; 401-408. urn:nbn:hr:105:048627
Mareković, Ivana; Plečko, Vanda; Boras, Zagorka; Pavlović, Ladislav; Budimir, Ana; Bošnjak, Zrinka; Puretić, Hrvoje; Žele-Starčević, Lidija; Kalenić, Smilja

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Mareković, I., Plečko, V., Boras, Z., Pavlović, L., Budimir, A., Bošnjak, Z. ... Kalenić, S. (2012). Value of rapid aetiological diagnosis in optimization of antimicrobial treatment in bacterial community acquired pneumonia . Collegium Antropologicum, 36. (2), 401-408. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:048627

Mareković, Ivana, et al. "Value of rapid aetiological diagnosis in optimization of antimicrobial treatment in bacterial community acquired pneumonia ." Collegium Antropologicum, vol. 36, no. 2, 2012, pp. 401-408. https://urn.nsk.hr/urn:nbn:hr:105:048627

Mareković, Ivana, Vanda Plečko, Zagorka Boras, Ladislav Pavlović, Ana Budimir, Zrinka Bošnjak, Hrvoje Puretić, Lidija Žele Starčević and Smilja Kalenić. "Value of rapid aetiological diagnosis in optimization of antimicrobial treatment in bacterial community acquired pneumonia ." Collegium Antropologicum 36, no. 2 (2012): 401-408. https://urn.nsk.hr/urn:nbn:hr:105:048627

Mareković, I., et al. (2012) 'Value of rapid aetiological diagnosis in optimization of antimicrobial treatment in bacterial community acquired pneumonia ', Collegium Antropologicum, 36(2), pp. 401-408. Available at: https://urn.nsk.hr/urn:nbn:hr:105:048627 (Accessed 21 December 2024)

Mareković I, Plečko V, Boras Z, Pavlović L, Budimir A, Bošnjak Z, and sur.. Value of rapid aetiological diagnosis in optimization of antimicrobial treatment in bacterial community acquired pneumonia . Collegium Antropologicum [Internet]. 2012 June [cited 2024 December 21];36(2):401-408. Available at: https://urn.nsk.hr/urn:nbn:hr:105:048627

I. Mareković, et al., "Value of rapid aetiological diagnosis in optimization of antimicrobial treatment in bacterial community acquired pneumonia ", Collegium Antropologicum, vol. 36, no. 2, pp. 401-408, June 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:048627. [Accessed: 21 December 2024]

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Title (english)Value of rapid aetiological diagnosis in optimization of antimicrobial treatment in bacterial community acquired pneumonia
Title (croatian)Značenje brze etiološke dijagnoze u optimizaciji antimikrobnog liječenja bolesnika s izvanbolničkom pneumonijom uzrokovanom bakterijama
AuthorIvana Mareković
AuthorVanda Plečko
AuthorZagorka Boras
AuthorLadislav Pavlović
AuthorAna Budimir
AuthorZrinka Bošnjak
AuthorHrvoje Puretić
AuthorLidija Žele-Starčević
AuthorSmilja Kalenić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
In 80 adult patients with community acquired pneumonia (CAP) conventional microbiological methods, polymerase chain reaction (PCR) and serum C-reactive protein (CRP) levels were performed and the appropriateness of the empirical antimicrobial treatment was evaluated according to bacterial pathogen detected. The aetiology was determined in 42 (52.5%) patients, with Streptococcus pneumoniae as the most common pathogen. PCR applied to bronchoalveolar lavage (BAL) provided 2 and PCR on sputum samples 1 additional aetiological diagnosis of CAP The mean CRP values in the S. pneumoniae group were not significantly higher than in the group with other aetiological diagnoses (166.89 mg/L vs. 160.11 mg/L, p = 0.457). In 23.8% (10/42) of patients with determined aetiology, the empirical antimicrobial treatment was inappropriate. PCR tests need further investigation, particularly those for the atypical pathogens, as they are predominant in inappropriately treated patients. Our results do not support the use of CRP as a rapid test to guide the antimicrobial treatment in patients with CAP.
Abstract (croatian)
Kod 80 bolesnika s izvanbolničkom pneumonijom napravljene su konvencionalne mikrobiološke pretrage i lančana reakcija polimeraze (PCR), te određen C-reaktivni protein (CRP) u serumu. Adekvatnost empirijskog antimikrobnog liječenja evaluirana je prema detektiranom bakterijskom patogenu. Etiologija je utvrđena kod 42 (52,5%) bolesnika, a najčešći patogen bio je Streptococcus pneumoniae. PCR-om na uzorcima bronhoalveolarnih lavata i sputuma utvrđena je etiološka dijagnoza kod 2 odnosno 1 bolesnika kod kojih to nije bilo moguće s konvencionalnim mikrobiološkim metodama. Prosječne CRP vrijednosti kod bolesnika sa S. pneumoniae nisu bile statistički značajno veće u usporedbi s onima kod bolesnika s drugom etiologijom pneumonije (166,89 mg/L vs.160,11 mg/L, p=0,457). Kod 23.8% (10/42) bolesnika s utvrđenom etiologijom empirijsko antimikrobno liječenje bilo je nedekvatno. PCR metode u dijagnostici izvanbolničkih pneumonija zahtijevaju daljnje istraživanje. To se osobito odnosi na PCR metode za detekciju atipičnih patogena budući da oni prevladavaju kod neadekvatno liječenih bolesnika. Rezultati ovog istraživanja ne pokazuju da bi CRP bio koristan kao brzi test prema kojem bi se usmjeravalo antimikrobno liječenje kod bolesnika s izvanbolničkom pneumonijom.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 36, no. 2, pp. 401-408
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:048627
Publication2012-06
Document URLhttps://hrcak.srce.hr/84776
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:37:24