prikaz prve stranice dokumenta Predictors of short-term neurocognitive outcome following coronary revascularisation (CABG) depending on the use of cardiopulmonary bypass
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Scientific paper - Original scientific paper
Predictors of short-term neurocognitive outcome following coronary revascularisation (CABG) depending on the use of cardiopulmonary bypass
Collegium Antropologicum, 36 (2012), 3; 827-833. urn:nbn:hr:105:348619
Lazibat, Ines; Sutlić, Željko; Brkić, Kristina; Nevajda, Branimir; Šikić, Jozica; Havelka Meštrović, Ana

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Lazibat, I., Sutlić, Ž., Brkić, K., Nevajda, B., Šikić, J. & Havelka Meštrović, A. (2012). Predictors of short-term neurocognitive outcome following coronary revascularisation (CABG) depending on the use of cardiopulmonary bypass . Collegium Antropologicum, 36. (3), 827-833. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:348619

Lazibat, Ines, et al. "Predictors of short-term neurocognitive outcome following coronary revascularisation (CABG) depending on the use of cardiopulmonary bypass ." Collegium Antropologicum, vol. 36, no. 3, 2012, pp. 827-833. https://urn.nsk.hr/urn:nbn:hr:105:348619

Lazibat, Ines, Željko Sutlić, Kristina Brkić, Branimir Nevajda, Jozica Šikić and Ana Havelka Meštrović. "Predictors of short-term neurocognitive outcome following coronary revascularisation (CABG) depending on the use of cardiopulmonary bypass ." Collegium Antropologicum 36, no. 3 (2012): 827-833. https://urn.nsk.hr/urn:nbn:hr:105:348619

Lazibat, I., et al. (2012) 'Predictors of short-term neurocognitive outcome following coronary revascularisation (CABG) depending on the use of cardiopulmonary bypass ', Collegium Antropologicum, 36(3), pp. 827-833. Available at: https://urn.nsk.hr/urn:nbn:hr:105:348619 (Accessed 26 May 2024)

Lazibat I, Sutlić Ž, Brkić K, Nevajda B, Šikić J, Havelka Meštrović A. Predictors of short-term neurocognitive outcome following coronary revascularisation (CABG) depending on the use of cardiopulmonary bypass . Collegium Antropologicum [Internet]. 2012 September [cited 2024 May 26];36(3):827-833. Available at: https://urn.nsk.hr/urn:nbn:hr:105:348619

I. Lazibat, Ž. Sutlić, K. Brkić, B. Nevajda, J. Šikić and A. Havelka Meštrović, "Predictors of short-term neurocognitive outcome following coronary revascularisation (CABG) depending on the use of cardiopulmonary bypass ", Collegium Antropologicum, vol. 36, no. 3, pp. 827-833, September 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:348619. [Accessed: 26 May 2024]

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Title (english)Predictors of short-term neurocognitive outcome following coronary revascularisation (CABG) depending on the use of cardiopulmonary bypass
Title (croatian)Prediktori kratkoročnog neurokognitivnog ishoda nakon koronarne revaskularizacije (CABG) ovisno o upotrebi izvantjelesnog krvotoka
AuthorInes Lazibat
AuthorŽeljko Sutlić
AuthorKristina Brkić
AuthorBranimir Nevajda
AuthorJozica Šikić
AuthorAna Havelka Meštrović
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The purpose of our study was to investigate the association between perioperative cerebral microembolization, expressed as high-intensity transient signals (HITS) and postoperative dynamics of the neuromarker S100P in patients operated using cardiopulmonary bypass, and to assess their impact upon the neurocognitive function in the early postoperative stage. The study involved 62 consecutive male patients aged 60 or above, alls scheduled for elective aortocoronary bypass. The patients were recruited from two groups with respect to the use of CPB: on-pump group (CPB+, N = 30) and off-pump group (CPB-, N = 32). In all patients we performed intraoperative monitoring of cerebral haemodynamics using transcranial Doppler, with the goal of quantifying perioperative cerebral microembolization. The serum levels of the neuromarker S100l were measured immediately after surgery, and then 12, 24 and 48 hours after the surgery. Neurocognitive status was assessed before and after the surgery and in three cognitive domains. Results of the study have shown that with respect to the short-term postoperative neurocognitive outcome there is no significant difference between the on-pump and off-pump surgical technique of coronary revascularization'. Perioperative cerebral microembolization was significantly more pronounced in the on-pump group yet it did not affect early postoperative neurocognitive function, while the increase in the neuromarker S100beta serum level 48 hours after surgery may have prognostic value as a predictor of postoperative neurocognitive dysfunction.
Abstract (croatian)
Istraživanje je provedeno sa svrhom ispitivanja povezanosti perioperacijske cerebralne mikroembolizacije (HITS) i poslijeoperacijske dinamike neurobiljega S100b s primjenom izvantjelesnog krvotoka (CPB), te utvrđivanjem njihovog učinka na neurokognitivnu funkciju u ranom poslijeoperacijskom razdoblju. U ispitivanje su uključena 62 konsekutivna muška bolesnika starija od 60 godina predviđena za elektivnu operaciju aortokoronarnog premoštenja. Bolesnici su regrutirani iz dvije skupine s obzirom na uporabu CPB: on-pump skupina (CPB+, N=30) i off-pump skupina (CPB–, N=32). Kod svih ispitanika provedeno je intraoperacijsko monitoriranje cerebralne hemodinamike transkranijskim doplerom u cilju kvantificiranja perioperacijske cerebralne mikroembolizacije. Serumske razine neurobiljega S100b mjerene su prije operacije, neposredno nakon operacije te 12, 24 i 48 sati od operacije. Neurokognitivni status se ocjenjivao prije i poslijeoperacijski u tri kognitivne domene. Rezultati istraživanja pokazuju da nema značajne razlike između on-pump i off-pump kirurške tehnike koronarne revaskularizacije s aspekta kratkoročnog poslijeoperacijskog neurokognitivnog ishoda. Perioperacijska cerebralna mikroembolizacija značajno je izraženija uz primjenu izvantjelesnog krovotoka ali ne utječe na ranu poslijeoperacijsku neurokognitivnu funkciju, dok porast serumske razine neurobiljega S100b 48 sati nakon operacije može imati prognostičku vrijednost kao mogući prediktor poslijeoperacijske neurokognitivne disfunkcije.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 36, no. 3, pp. 827-833
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:348619
Publication2012-09
Document URLhttps://hrcak.srce.hr/90367
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:38:34