prikaz prve stranice dokumenta Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation
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Scientific paper - Original scientific paper
Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation
Toxicology in Vitro, 27 (2013), 2; 523-532. https://doi.org/10.1016/j.tiv.2012.11.003
Rak, Sanjica; Čimbora-Zovko, Tamara; Gajski, Goran; Dubravčić, Klara; Domijan, Ana-Marija; Delaš, Ivančica; Garaj-Vrhovac, Verica; Batinić, Drago; Sorić, Jasna; Osmak, Maja

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Rak, S., Čimbora Zovko, T., Gajski, G., Dubravčić, K., Domijan, A. M., Delaš, I. ... Osmak, M. (2013). Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation. Toxicology in Vitro, 27. (2), 523-532. doi: 10.1016/j.tiv.2012.11.003

Rak, Sanjica, et al. "Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation." Toxicology in Vitro, vol. 27, no. 2, 2013, pp. 523-532. https://doi.org/10.1016/j.tiv.2012.11.003

Rak, Sanjica, Tamara Čimbora Zovko, Goran Gajski, Klara Dubravčić, Ana Marija Domijan, Ivančica Delaš, Verica Garaj Vrhovac, Drago Batinić, Jasna Sorić and Maja Osmak. "Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation." Toxicology in Vitro 27, no. 2 (2013): 523-532. https://doi.org/10.1016/j.tiv.2012.11.003

Rak, S., et al. (2013) 'Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation', Toxicology in Vitro, 27(2), pp. 523-532. doi: 10.1016/j.tiv.2012.11.003

Rak S, Čimbora Zovko T, Gajski G, Dubravčić K, Domijan AM, Delaš I, and sur.. Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation. Toxicology in Vitro [Internet]. 2013 March [cited 2024 November 08];27(2):523-532. doi: 10.1016/j.tiv.2012.11.003

S. Rak, et al., "Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation", Toxicology in Vitro, vol. 27, no. 2, pp. 523-532, March 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:395887. [Accessed: 08 November 2024]

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Metadata
Title (english)Carboplatin resistant human laryngeal carcinoma cells are cross resistant to curcumin due to reduced curcumin accumulation
AuthorSanjica Rak
AuthorTamara Čimbora-Zovko
AuthorGoran Gajski
AuthorKlara Dubravčić
AuthorAna-Marija Domijan
AuthorIvančica Delaš
AuthorVerica Garaj-Vrhovac
AuthorDrago Batinić
AuthorJasna Sorić
AuthorMaja Osmak
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Curcumin is a natural compound that exhibits a wide range of beneficial effects, among them the anti-tumor activity. Recently it was shown that curcumin may be efficient against drug resistant tumor cells. The goal of our investigation was to examine if human laryngeal carcinoma cells resistant to carboplatin display sensitivity to curcumin, as compared to parental cells, and if this sensitivity is altered, to determine the molecular mechanisms that are responsible for it. We found that carboplatin resistant 7T cells were also cross resistant to curcumin. After the treatment with equimolar concentration of curcumin, 7T cells exhibited lower intracellular accumulation of curcumin which coincided with reduced formation of reactive oxygen species (ROS), diminished lipid and DNA damage followed by reduced induction of apoptosis and expression of heat shock protein 70 (Hsp70), as compared to parental HEp-2 cells. However, after the treatment with equitoxic concentration of curcumin, intracellular accumulation and all the explored downstream effects were similar in both cell lines suggesting that resistance of 7T cells to curcumin was based on its reduced intracellular accumulation. Since curcumin accumulates mostly in the membranes, we explored the fatty acid composition of both cell lines, but we did not find any difference between them.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleToxicology in Vitro
Numberingvol. 27, no. 2, pp. 523-532
p-ISSN0887-2333
DOIhttps://doi.org/10.1016/j.tiv.2012.11.003
URN:NBNurn:nbn:hr:105:395887
Publication2013-03
Document URLhttps://doi.org/10.1016/j.tiv.2012.11.003
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 19:43:51