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Scientific paper - Original scientific paper
An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization
Bioorganic & Medicinal Chemistry, 20 (2012), 10; 3180-3185. https://doi.org/10.1016/j.bmc.2012.03.074
Verbanac, Donatella; Jain, Subhash C.; Jain, Nidhi; Chand, Mahesh; Čipčić Paljetak, Hana; Matijašić, Mario; Perić, Mihaela; Stepanić, Višnja; Saso, Luciano

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Verbanac, D., Jain, S. C., Jain, N., Chand, M., Čipčić Paljetak, H., Matijašić, M. ... Saso, L. (2012). An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization. Bioorganic & Medicinal Chemistry, 20. (10), 3180-3185. doi: 10.1016/j.bmc.2012.03.074

Verbanac, Donatella, et al. "An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization." Bioorganic & Medicinal Chemistry, vol. 20, no. 10, 2012, pp. 3180-3185. https://doi.org/10.1016/j.bmc.2012.03.074

Verbanac, Donatella, Subhash C. Jain, Nidhi Jain, Mahesh Chand, Hana Čipčić Paljetak, Mario Matijašić, Mihaela Perić, Višnja Stepanić and Luciano Saso. "An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization." Bioorganic & Medicinal Chemistry 20, no. 10 (2012): 3180-3185. https://doi.org/10.1016/j.bmc.2012.03.074

Verbanac, D., et al. (2012) 'An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization', Bioorganic & Medicinal Chemistry, 20(10), pp. 3180-3185. doi: 10.1016/j.bmc.2012.03.074

Verbanac D, Jain SC, Jain N, Chand M, Čipčić Paljetak H, Matijašić M, and sur.. An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization. Bioorganic & Medicinal Chemistry [Internet]. 2012 May 15 [cited 2024 May 10];20(10):3180-3185. doi: 10.1016/j.bmc.2012.03.074

D. Verbanac, et al., "An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization", Bioorganic & Medicinal Chemistry, vol. 20, no. 10, pp. 3180-3185, May 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:669055. [Accessed: 10 May 2024]

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Title (english)An efficient and convenient microwave-assisted chemical synthesis of (thio)xanthones with additional in vitro and in silico characterization
AuthorDonatella Verbanac
AuthorSubhash C. Jain
AuthorNidhi Jain
AuthorMahesh Chand
AuthorHana Čipčić Paljetak
AuthorMario Matijašić
AuthorMihaela Perić
AuthorVišnja Stepanić
AuthorLuciano Saso
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Xanthones and their thio-derivatives are a class of pleiotropic compounds with various reported pharmacological and biological activities. Although these activities are mainly determined in laboratory conditions, the class itself has a great potential to be utilized as promising chemical scaffold for the synthesis of new drug candidates. One of the main obstacles in utilization of these compounds was related to the difficulties in their chemical synthesis. Most of the known methods require two steps, and are limited to specific reagents not applicable to a large number of starting materials. In this paper a new and improved method for chemical synthesis of xanthones is presented. By applying a new procedure, we have successfully obtained these compounds with the desired regioselectivity in a shorter reaction time (50s) and with better yield (>80%). Finally, the preliminary in vitro screenings on different bacterial species and cytotoxicity assessment, as well as in silico activity evaluation were performed. The obtained results confirm potential pharmacological use of this class of molecules.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleBioorganic & Medicinal Chemistry
Numberingvol. 20, no. 10, pp. 3180-3185
p-ISSN0968-0896
DOIhttps://doi.org/10.1016/j.bmc.2012.03.074
URN:NBNurn:nbn:hr:105:669055
Publication2012-05-15
Document URLhttps://doi.org/10.1016/j.bmc.2012.03.074
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:03:26