prikaz prve stranice dokumenta Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells
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Scientific paper - Original scientific paper
Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells
Leukemia Research, 37 (2013), 6; 705-712. https://doi.org/10.1016/j.leukres.2013.03.002
Topić, Iva; Ikić, Marina; Ivčević, Sanja; Kovačić, Nataša; Marušić, Ana; Kušec, Rajko; Grčević, Danka

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Topić, I., Ikić, M., Ivčević, S., Kovačić, N., Marušić, A., Kušec, R. & Grčević, D. (2013). Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells. Leukemia Research, 37. (6), 705-712. doi: 10.1016/j.leukres.2013.03.002

Topić, Iva, et al. "Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells." Leukemia Research, vol. 37, no. 6, 2013, pp. 705-712. https://doi.org/10.1016/j.leukres.2013.03.002

Topić, Iva, Marina Ikić, Sanja Ivčević, Nataša Kovačić, Ana Marušić, Rajko Kušec and Danka Grčević. "Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells." Leukemia Research 37, no. 6 (2013): 705-712. https://doi.org/10.1016/j.leukres.2013.03.002

Topić, I., et al. (2013) 'Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells', Leukemia Research, 37(6), pp. 705-712. doi: 10.1016/j.leukres.2013.03.002

Topić I, Ikić M, Ivčević S, Kovačić N, Marušić A, Kušec R, and sur.. Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells. Leukemia Research [Internet]. 2013 June [cited 2024 April 10];37(6):705-712. doi: 10.1016/j.leukres.2013.03.002

I. Topić, et al., "Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells", Leukemia Research, vol. 37, no. 6, pp. 705-712, June 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:799592. [Accessed: 10 April 2024]

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Metadata
Title (english)Bone morphogenetic proteins regulate differentiation of human promyelocytic leukemia cells
AuthorIva Topić
AuthorMarina Ikić
AuthorSanja Ivčević
AuthorNataša Kovačić
AuthorAna Marušić
AuthorRajko Kušec
AuthorDanka Grčević
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
We investigated the role of bone morphogenetic proteins (BMPs) in suppression of all-trans retinoic acid (ATRA)-mediated differentiation of leukemic promyelocytes. In NB4 and HL60 cell lines, BMPs reduced the percentage of differentiated cells, and suppressed PU.1 and C/EBPε gene expression induced by ATRA. BMP and ATRA synergized in the induction of ID genes, causing suppression of differentiation. In primary acute promyelocytic leukemia bone-marrow samples, positive correlation of PML/RARα and negative of RARα with the expression of BMP-4, BMP-6 and ID genes were found. We concluded that BMPs may have oncogenic properties and mediate ATRA resistance by a mechanism that involves ID genes.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleLeukemia Research
Numberingvol. 37, no. 6, pp. 705-712
p-ISSN0145-2126
DOIhttps://doi.org/10.1016/j.leukres.2013.03.002
URN:NBNurn:nbn:hr:105:799592
Publication2013-06
Document URLhttps://doi.org/10.1016/j.leukres.2013.03.002
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:02:50