prikaz prve stranice dokumenta The effects of olanzapine and fluphenazine on plasma cortisol, prolactin and muscle rigidity in schizophrenic patients: a double blind study
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Scientific paper - Original scientific paper
The effects of olanzapine and fluphenazine on plasma cortisol, prolactin and muscle rigidity in schizophrenic patients: a double blind study
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 31 (2007), 2; 399-402. https://doi.org/10.1016/j.pnpbp.2006.10.007
Jakovljević, Miro; Pivac, Nela; Mihaljević-Peleš, Alma; Mustapić, Maja; Relja, Maja; Ljubičić, Đulijano; Marčinko, Darko; Muck-Šeler, Dorotea

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Jakovljević, M., Pivac, N., Mihaljević Peleš, A., Mustapić, M., Relja, M., Ljubičić, Đ. ... Muck Šeler, D. (2007). The effects of olanzapine and fluphenazine on plasma cortisol, prolactin and muscle rigidity in schizophrenic patients: a double blind study. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 31. (2), 399-402. doi: 10.1016/j.pnpbp.2006.10.007

Jakovljević, Miro, et al. "The effects of olanzapine and fluphenazine on plasma cortisol, prolactin and muscle rigidity in schizophrenic patients: a double blind study." Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 31, no. 2, 2007, pp. 399-402. https://doi.org/10.1016/j.pnpbp.2006.10.007

Jakovljević, Miro, Nela Pivac, Alma Mihaljević Peleš, Maja Mustapić, Maja Relja, Đulijano Ljubičić, Darko Marčinko and Dorotea Muck Šeler. "The effects of olanzapine and fluphenazine on plasma cortisol, prolactin and muscle rigidity in schizophrenic patients: a double blind study." Progress in Neuro-Psychopharmacology and Biological Psychiatry 31, no. 2 (2007): 399-402. https://doi.org/10.1016/j.pnpbp.2006.10.007

Jakovljević, M., et al. (2007) 'The effects of olanzapine and fluphenazine on plasma cortisol, prolactin and muscle rigidity in schizophrenic patients: a double blind study', Progress in Neuro-Psychopharmacology and Biological Psychiatry, 31(2), pp. 399-402. doi: 10.1016/j.pnpbp.2006.10.007

Jakovljević M, Pivac N, Mihaljević Peleš A, Mustapić M, Relja M, Ljubičić Đ, and sur.. The effects of olanzapine and fluphenazine on plasma cortisol, prolactin and muscle rigidity in schizophrenic patients: a double blind study. Progress in Neuro-Psychopharmacology and Biological Psychiatry [Internet]. 2007 March 30 [cited 2024 November 29];31(2):399-402. doi: 10.1016/j.pnpbp.2006.10.007

M. Jakovljević, et al., "The effects of olanzapine and fluphenazine on plasma cortisol, prolactin and muscle rigidity in schizophrenic patients: a double blind study", Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 31, no. 2, pp. 399-402, March 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:462924. [Accessed: 29 November 2024]

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Title (english)The effects of olanzapine and fluphenazine on plasma cortisol, prolactin and muscle rigidity in schizophrenic patients: a double blind study
AuthorMiro Jakovljević
AuthorNela Pivac
AuthorAlma Mihaljević-Peleš
AuthorMaja Mustapić
AuthorMaja Relja
AuthorĐulijano Ljubičić
AuthorDarko Marčinko
AuthorDorotea Muck-Šeler
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Pharmacotherapy of schizophrenia is associated with the stressful side effects. Muscle rigidity causes distress, discomfort and poor compliance. The aim of the study was to determine the relationship between plasma hormones (cortisol and prolactin/PRL) and muscle rigidity in female schizophrenic patients treated with olanzapine or fluphenazine. In a randomized, double-blind 22-weeks study, 12 patients were treated with olanzapine (5-20 mg/day) and 10 patients received fluphenazine (6-21 mg/day). Treatment with olanzapine moderately decreased, while treatment with fluphenazine significantly increased plasma cortisol levels and muscle rigidity. The marked and moderate increase in plasma PRL levels were found in patients treated with fluphenazine and olanzapine, respectively. The results suggested that olanzapine induced moderate neuroendocrine effects and a reduction in rigidity as compared to fluphenazine treatment.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleProgress in Neuro-Psychopharmacology and Biological Psychiatry
Numberingvol. 31, no. 2, pp. 399-402
p-ISSN0278-5846
DOIhttps://doi.org/10.1016/j.pnpbp.2006.10.007
URN:NBNurn:nbn:hr:105:462924
Publication2007-03-30
Document URLhttps://doi.org/10.1016/j.pnpbp.2006.10.007
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:04:04