prikaz prve stranice dokumenta Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study
  Download
PDF 262.64 KB
Scientific paper - Original scientific paper
Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study
European Journal of Cardio-Thoracic Surgery, 31 (2007), 3; 366-371. https://doi.org/10.1016/j.ejcts.2006.12.003
Barić, Davor; Biočina, Bojan; Unić, Daniel; Sutlić, Željko; Rudež, Igor; Bačić Vrca, Vesna; Brkić, Kristina; Ivković, Mira

Cite this document

Barić, D., Biočina, B., Unić, D., Sutlić, Ž., Rudež, I., Bačić Vrca, V. ... Ivković, M. (2007). Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study. European Journal of Cardio-Thoracic Surgery, 31. (3), 366-371. doi: 10.1016/j.ejcts.2006.12.003

Barić, Davor, et al. "Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study." European Journal of Cardio-Thoracic Surgery, vol. 31, no. 3, 2007, pp. 366-371. https://doi.org/10.1016/j.ejcts.2006.12.003

Barić, Davor, Bojan Biočina, Daniel Unić, Željko Sutlić, Igor Rudež, Vesna Bačić Vrca, Kristina Brkić and Mira Ivković. "Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study." European Journal of Cardio-Thoracic Surgery 31, no. 3 (2007): 366-371. https://doi.org/10.1016/j.ejcts.2006.12.003

Barić, D., et al. (2007) 'Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study', European Journal of Cardio-Thoracic Surgery, 31(3), pp. 366-371. doi: 10.1016/j.ejcts.2006.12.003

Barić D, Biočina B, Unić D, Sutlić Ž, Rudež I, Bačić Vrca V, and sur.. Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study. European Journal of Cardio-Thoracic Surgery [Internet]. 2007 March [cited 2025 February 13];31(3):366-371. doi: 10.1016/j.ejcts.2006.12.003

D. Barić, et al., "Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study", European Journal of Cardio-Thoracic Surgery, vol. 31, no. 3, pp. 366-371, March 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:303453. [Accessed: 13 February 2025]

Please login to the repository to save this object to your list.
Metadata
Title (english)Topical use of antifibrinolytic agents reduces postoperative bleeding: a double-blind, prospective, randomized study
AuthorDavor Barić
AuthorBojan Biočina
AuthorDaniel Unić
AuthorŽeljko Sutlić
AuthorIgor Rudež
AuthorVesna Bačić Vrca
AuthorKristina Brkić
AuthorMira Ivković
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Objective: Postoperative bleeding is still one of the most common complications of cardiac surgery. Antifibrinolytic agents successfully reduce bleeding, but there are controversies concerning adverse effects after their systemic use. By topical application of antifibrinolytic agents in pericardial cavity, most of these effects are avoided. We compared the effects of topically applied aprotinin, tranexamic acid and placebo on postoperative bleeding and transfusion requirements. - - - - - Methods: In this single-center prospective, randomized, double-blind trial, 300 adult cardiac patients were randomized into three groups to receive one million IU of aprotinin (AP group), 2.5g of tranexamic acid (TA group) or placebo (PL group) topically before sternal closure. Groups were comparable with respect to all preoperative and intraoperative variables. Postoperative bleeding, transfusion requirements and hematologic parameters were evaluated. - - - - - Results: Postoperative bleeding within first 12-h period (AP group 433+/-294 [350; 360]ml, TA group 391+/-255 [350; 305]ml, PL group 613+/-505 [525; 348]ml), as well as cumulative blood loss within 24h (AP group 726+/-432 [640; 525]ml, TA group 633+/-343 [545; 335]ml, PL group 903+/-733 [800; 445]ml), showed statistically significant inter-group differences (both p<0.001). Bleeding rates values were significantly higher in placebo group compared to the groups treated with antifibrinolytic agents (AP and TA groups) concerning both variables. Although TA group showed the lowest values, no statistical differences between TA and AP groups were found. Inter-group difference of blood product requirements was not statistically significant. - - - - - Conclusions: Topical use of either tranexamic acid or aprotinin efficiently reduces postoperative bleeding. TA seems to be at least as potent as aprotinin, but potentially safer and with better cost-effectiveness ratio.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleEuropean Journal of Cardio-Thoracic Surgery
Numberingvol. 31, no. 3, pp. 366-371
p-ISSN1010-7940
DOIhttps://doi.org/10.1016/j.ejcts.2006.12.003
URN:NBNurn:nbn:hr:105:303453
Publication2007-03
Document URLhttps://doi.org/10.1016/j.ejcts.2006.12.003
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:06:46