prikaz prve stranice dokumenta TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions
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Scientific paper - Original scientific paper
TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions
Experimental and Molecular Pathology, 83 (2007), 1; 54-58. https://doi.org/10.1016/j.yexmp.2006.11.004
Sirotković-Skerlev, Maja; Čačev, Tamara; Križanac, Šimun; Kulić, Ana; Pavelić, Krešimir; Kapitanović, Sanja

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Sirotković Skerlev, M., Čačev, T., Križanac, Š., Kulić, A., Pavelić, K. & Kapitanović, S. (2007). TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions. Experimental and Molecular Pathology, 83. (1), 54-58. doi: 10.1016/j.yexmp.2006.11.004

Sirotković Skerlev, Maja, et al. "TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions." Experimental and Molecular Pathology, vol. 83, no. 1, 2007, pp. 54-58. https://doi.org/10.1016/j.yexmp.2006.11.004

Sirotković Skerlev, Maja, Tamara Čačev, Šimun Križanac, Ana Kulić, Krešimir Pavelić and Sanja Kapitanović. "TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions." Experimental and Molecular Pathology 83, no. 1 (2007): 54-58. https://doi.org/10.1016/j.yexmp.2006.11.004

Sirotković Skerlev, M., et al. (2007) 'TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions', Experimental and Molecular Pathology, 83(1), pp. 54-58. doi: 10.1016/j.yexmp.2006.11.004

Sirotković Skerlev M, Čačev T, Križanac Š, Kulić A, Pavelić K, Kapitanović S. TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions. Experimental and Molecular Pathology [Internet]. 2007 August [cited 2024 May 03];83(1):54-58. doi: 10.1016/j.yexmp.2006.11.004

M. Sirotković Skerlev, T. Čačev, Š. Križanac, A. Kulić, K. Pavelić and S. Kapitanović, "TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions", Experimental and Molecular Pathology, vol. 83, no. 1, pp. 54-58, August 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:469921. [Accessed: 03 May 2024]

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Metadata
Title (english)TNF alpha promoter polymorphisms analysis in benign and malignant breast lesions
AuthorMaja Sirotković-Skerlev
AuthorTamara Čačev
AuthorŠimun Križanac
AuthorAna Kulić
AuthorKrešimir Pavelić
AuthorSanja Kapitanović
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Polymorphisms in genes involved in the complex mechanisms of carcinogenesis may affect the susceptibility to cancer. The multifunctional cytokine tumor necrosis factor alpha (TNF alpha) has an important role in the pathogenesis of inflammatory, autoimmune and malignant diseases. It has a large spectrum of activities, including both antitumorigenic and protumorigenic. In recent years, several TNF alpha promoter polymorphisms have been identified and related to the expression level of cytokine and to the susceptibility to solid tumors. The aim of our study was to investigate the frequency of three TNF alpha promoter polymorphisms (-1031, -308 and -238) in benign (fibrocystic changes) and malignant (invasive carcinoma) breast lesions. Using "real-time" PCR SNP analysis these polymorphisms were determined in 76 patients with benign and 158 patients with malignant breast lesions. The high expression genotypes at any of the three SNP polymorphisms were more frequent in invasive breast carcinoma (in 81 of 158 examined, 51.3%) than in fibrocystic changes (in 33 of 76 examined, 43.4%). The combined frequency of high production genotypes (-1031 T/C and C/C, -308 G/A and A/A and -238 G/A and A/A) was higher in patients with invasive breast carcinoma than in those with fibrocystic changes. However, these results were not statistically significant. Further studies on a larger group of patients are needed to evaluate the significance of potential differences in TNF alpha genotypes in different breast lesions.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleExperimental and Molecular Pathology
Numberingvol. 83, no. 1, pp. 54-58
p-ISSN0014-4800
DOIhttps://doi.org/10.1016/j.yexmp.2006.11.004
URN:NBNurn:nbn:hr:105:469921
Publication2007-08
Document URLhttps://doi.org/10.1016/j.yexmp.2006.11.004
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:06:59