Update on the core and developing cerebrospinal fluid biomarkers for Alzheimer disease

Scientific paper - Original scientific paper

• Author: Mirjana Babić
• Author: Dubravka Švob Štrac
• Author: Dorotea Mück-Šeler
• Author: Nela Pivac
• Author: Gabrijela Stanić
• Author: Patrick R. Hof
• Author: Goran Šimić
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

Alzheimer disease (AD) is a complex neurodegenerative disorder, whose prevalence will dramatically rise by 2050. Despite numerous clinical trials investigating this disease, there is still no effective treatment. Many trials showed negative or inconclusive results, possibly because they recruited only patients with severe disease, who had not undergone disease-modifying therapies in preclinical stages of AD before severe degeneration occurred. Detection of AD in asymptomatic at risk individuals (and a few presymptomatic individuals who carry an autosomal dominant monogenic AD mutation) remains impractical in many of clinical situations and is possible only with reliable biomarkers. In addition to early diagnosis of AD, biomarkers should serve for monitoring disease progression and response to therapy. To date, the most promising biomarkers are cerebrospinal fluid (CSF) and neuroimaging biomarkers. Core CSF biomarkers (amyloid β1-42, total tau, and phosphorylated tau) showed a high diagnostic accuracy but were still unreliable for preclinical detection of AD. Hence, there is an urgent need for detection and validation of novel CSF biomarkers that would enable early diagnosis of AD in asymptomatic individuals. This article reviews recent research advances on biomarkers for AD, focusing mainly on the CSF biomarkers. In addition to core CSF biomarkers, the potential usefulness of novel CSF biomarkers is discussed.

• Keywords (english): Alzheimer Disease / blood; Alzheimer Disease / cerebrospinal fluid; Alzheimer Disease / diagnosis; Alzheimer Disease / genetics; Amyloid beta-Peptides / cerebrospinal fluid; Biomarkers / blood; Biomarkers / cerebrospinal fluid; Early Diagnosis; Humans; Magnetic Resonance Imaging; Phosphorylation; tau Proteins / cerebrospinal fluid; tau Proteins / metabolism
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Croatian Medical Journal
• Numbering: vol. 55, no. 4, pp. 347-365
• p-ISSN: 0353-9504
• DOI: https://doi.org/10.3325/cmj.2014.55.347
• URN:NBN: urn:nbn:hr:105:071815
• Publication: 2014-08-28
• Document URL: https://doi.org/10.3325/cmj.2014.55.347
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-27 20:10:20