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Scientific paper - Original scientific paper
The relationship between methylenetetrahydrofolate reductase C677T gene polymorphism and diabetic nephropathy in Croatian type 2 diabetic patients
Collegium Antropologicum, 37 (2013), 3; 789-793. urn:nbn:hr:105:900867
Gojo Tomić, Nives; Marušić, Srećko; Božikov, Velimir; Kušec, Rajko; Bačić-Vrca, Vesna; Tadić, Mario

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Gojo Tomić, N., Marušić, S., Božikov, V., Kušec, R., Bačić Vrca, V. & Tadić, M. (2013). The relationship between methylenetetrahydrofolate reductase C677T gene polymorphism and diabetic nephropathy in Croatian type 2 diabetic patients . Collegium Antropologicum, 37. (3), 789-793. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:900867

Gojo Tomić, Nives, et al. "The relationship between methylenetetrahydrofolate reductase C677T gene polymorphism and diabetic nephropathy in Croatian type 2 diabetic patients ." Collegium Antropologicum, vol. 37, no. 3, 2013, pp. 789-793. https://urn.nsk.hr/urn:nbn:hr:105:900867

Gojo Tomić, Nives, Srećko Marušić, Velimir Božikov, Rajko Kušec, Vesna Bačić Vrca and Mario Tadić. "The relationship between methylenetetrahydrofolate reductase C677T gene polymorphism and diabetic nephropathy in Croatian type 2 diabetic patients ." Collegium Antropologicum 37, no. 3 (2013): 789-793. https://urn.nsk.hr/urn:nbn:hr:105:900867

Gojo Tomić, N., et al. (2013) 'The relationship between methylenetetrahydrofolate reductase C677T gene polymorphism and diabetic nephropathy in Croatian type 2 diabetic patients ', Collegium Antropologicum, 37(3), pp. 789-793. Available at: https://urn.nsk.hr/urn:nbn:hr:105:900867 (Accessed 25 February 2025)

Gojo Tomić N, Marušić S, Božikov V, Kušec R, Bačić Vrca V, Tadić M. The relationship between methylenetetrahydrofolate reductase C677T gene polymorphism and diabetic nephropathy in Croatian type 2 diabetic patients . Collegium Antropologicum [Internet]. 2013 September [cited 2025 February 25];37(3):789-793. Available at: https://urn.nsk.hr/urn:nbn:hr:105:900867

N. Gojo Tomić, S. Marušić, V. Božikov, R. Kušec, V. Bačić Vrca and M. Tadić, "The relationship between methylenetetrahydrofolate reductase C677T gene polymorphism and diabetic nephropathy in Croatian type 2 diabetic patients ", Collegium Antropologicum, vol. 37, no. 3, pp. 789-793, September 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:900867. [Accessed: 25 February 2025]

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Metadata
Title (english)The relationship between methylenetetrahydrofolate reductase C677T gene polymorphism and diabetic nephropathy in Croatian type 2 diabetic patients
Title (croatian)Povezanost polimirfizma C677T gena za metilentetrahidrofolat reduktazu i dijabetičke nefropatije u bolesnika sa šećernom bolesti tip 2 u Hrvatskoj
AuthorNives Gojo Tomić
AuthorSrećko Marušić
AuthorVelimir Božikov
AuthorRajko Kušec
AuthorVesna Bačić-Vrca
AuthorMario Tadić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Methylenetetrahydrofolate reductase (MTHFR) polymorphism has been shown to be associated with the development of diabetic nephropathy in many ethnic groups. In this study, we examined the correlation between MTHFR C677T polymorphism and microalbuminuria in patients with diabetes mellitus type 2 in Croatian patients. 85 patients with diabetes mellitus type 2 were recruited. Patients were classified into two groups--with and without diabetic nephropathy according to urinary albumin excretion rate in urine collected during 24 hours. The C677T genotype was determined by real-time PCR analysis. The genotype frequencies were CC 36.5%, CT 42.3% and TT 21.2% in diabetic patients without nephropathy versus CC 39.4%, CT 45.4% and TT 15.2% in those with nephropathy. There was no statistically significant difference in allele distribution between patients with nephropathy and those without (p = 0.788). Our study did not show a correlation between mutations in the MTHFR gene and diabetic nephropathy in Croatian patients. Diabetic nephropathy is influenced by multiple risk factors which can modify the importance of MTHFR polymorphism in its development.
Abstract (croatian)
Polimorfizam gena za metilentetrahidrofolat reduktazu (MTHFR) je povezan s razvojem dijabetičke nefropatije u mnogim etničkim skupinama.U ovoj studiji istraživali smo povezanost između polimorfizma C677T gena za MTHFR i mikroalbuminurije u bolesnika sa šećernom bolesti tip 2 u hrvatskih bolesnika. Osamdeset pet bolesnika sa šećernom bolesti je obrađivano i svrstano u dvije skupine – sa dijabetičkom nefropatijom i bez nje, ovisno o vrijednostima izlučenog albumina u 24-satnom urinu. Mutacija C677T gena za MTHFR određena je metodom izolacije DNA i alel specifične lančane reakcije polimeraze (PCR). Raspodjela genotipova u skupini bolesnika s normoalbuminurijom bila je: CC 36,5%, CT 42,3% i TT 21,2%, dok je u skupini bolesnika sa mikroalbuminurijom bila: CC 39,4%, CT 45,4% i TT 15,2%. Nije bilo statistički značajne razlike među grupama u distribuciji C677T genotipova (p=0,788). Naše istraživanje nije pokazalo povezanost između mutacije gena za metilentetrahidrofolat reduktazu i dijabetičke nefropatije u hrvatskih bolesnika. Mnogostruki čimbenici mogu modificirati značajnost utjecaja polimorfizma MTHFR na nastanak dijabetičke nefropatije.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 37, no. 3, pp. 789-793
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:900867
Publication2013-09
Document URLhttps://hrcak.srce.hr/118219
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:12:54