Successful delivery of fetus with fetal inherited thrombophilia after two fetal deaths

Scientific paper - Case study

• Title (croatian): Uspješno dovršenje trudnoće s djetetom s nasljednom trombofilijom nakon dvije fetalne smrti
• Author: Josip Juras
• Author: Marina Ivanišević
• Author: Slavko Orešković
• Author: Slobodan Mihaljević
• Author: Goran Vujić
• Author: Josip Đelmiš
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

A pregnant woman with inherited thrombophilia (factor II mutation--20210A) had two late pregnancy losses. The first pregnancy was not well documented, but the second pregnancy was complicated by fetal thrombophilia and umbilical artery thrombosis, proven after fetal death. During the third pregnancy enoxaparine was introduced in the therapy and early amniocentesis was performed. Fetal thrombophilia was proven again. Early delivery was induced and performed with no complications, resulting in a... More live healthy infant. A history of miscarriages or recurrent fetal loss should raise suspicion of thrombophilia as a potential cause. It is debatable whether amniocentesis in pursuit of fetal thrombophilia should be performed and whether this will lead to a better perinatal outcome. When fetal thrombophilia is diagnosed, an earlier induction of delivery should be considered, taking into account the fetal extrauterine viability. The aforementioned approach of early delivery in cases of inherited fetal thrombophilia could be a possible solution for better perinatal outcomes. Less

Abstract (croatian)

Trudnica s nasljednom trombofilijom (mutacija čimbenika II – 20210A) imala je dva gubitka trudnoće u poodmakloj
gestaciji. Tijek prve trudnoće nije detaljno dokumentiran, a druga trudnoća je bila komplicirana trombofilijom fetusa i
trombozom umbilikalne arterije, što je ustanovljeno nakon smrti fetusa. Tijekom treće trudnoće trudnica je liječena
enoksaparinom te je učinjena rana amniocenteza. Opet je fetus imao nasljednu trombofiliju. Učinjena je prijevremena
indukcija porođaja bez... More komplikacija, što je rezultiralo živim i zdravim djetetom. Pobačaji ili ponavljajuća smrt fetusa
trebala bi pobuditi sumnju na trombofiliju kao mogući uzrok. Upitno je je li potrebno izvođenje amniocenteze sa svrhom
traženja trombofilije u fetusa i utjecanja na bolji perinatalni ishod. U slučaju prisustva fetalne dijagnoze indukcija
porođaja prije termina bi se trebala razmotriti, uvažavajući sposobnost fetusa za život izvan maternice. Spomenuti
pristup u slučaju nasljedne fetalne trombofilije bi mogao biti potencijalno rješenje za bolji perinatalni ishod. Less

• Keywords (english): Adult; Female; Fetal Death; Humans; Pregnancy; Thrombophilia/congenital
• Language: english
• Publication type: Scientific paper - Case study
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Collegium Antropologicum
• Numbering: vol. 37, no. 4, pp. 1353-1355
• p-ISSN: 0350-6134
• URN:NBN: urn:nbn:hr:105:207521
• Publication: 2013-12
• Document URL: https://hrcak.srce.hr/118398
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-27 20:13:49