prikaz prve stranice dokumenta Expression of secreted frizzled-related protein 1 and 3, T-cell factor 1 and lymphoid enhancer factor 1 in clear cell renal cell carcinoma
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Scientific paper - Original scientific paper
Expression of secreted frizzled-related protein 1 and 3, T-cell factor 1 and lymphoid enhancer factor 1 in clear cell renal cell carcinoma
Pathology Oncology Research, 19 (2013), 3; 545-551. https://doi.org/10.1007/s12253-013-9615-3
Nikuševa-Martić, Tamara; Šerman, Ljiljana; Zeljko, Martina; Vidas, Željko; Gašparov, Slavko; Zeljko, Hrvojka Marija; Kosović, Marin; Pećina-Šlaus, Nives

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Nikuševa Martić, T., Šerman, Lj., Zeljko, M., Vidas, Ž., Gašparov, S., Zeljko, H. M. ... Pećina Šlaus, N. (2013). Expression of secreted frizzled-related protein 1 and 3, T-cell factor 1 and lymphoid enhancer factor 1 in clear cell renal cell carcinoma. Pathology Oncology Research, 19. (3), 545-551. doi: 10.1007/s12253-013-9615-3

Nikuševa Martić, Tamara, et al. "Expression of secreted frizzled-related protein 1 and 3, T-cell factor 1 and lymphoid enhancer factor 1 in clear cell renal cell carcinoma." Pathology Oncology Research, vol. 19, no. 3, 2013, pp. 545-551. https://doi.org/10.1007/s12253-013-9615-3

Nikuševa Martić, Tamara, Ljiljana Šerman, Martina Zeljko, Željko Vidas, Slavko Gašparov, Hrvojka Marija Zeljko, Marin Kosović and Nives Pećina Šlaus. "Expression of secreted frizzled-related protein 1 and 3, T-cell factor 1 and lymphoid enhancer factor 1 in clear cell renal cell carcinoma." Pathology Oncology Research 19, no. 3 (2013): 545-551. https://doi.org/10.1007/s12253-013-9615-3

Nikuševa Martić, T., et al. (2013) 'Expression of secreted frizzled-related protein 1 and 3, T-cell factor 1 and lymphoid enhancer factor 1 in clear cell renal cell carcinoma', Pathology Oncology Research, 19(3), pp. 545-551. doi: 10.1007/s12253-013-9615-3

Nikuševa Martić T, Šerman Lj, Zeljko M, Vidas Ž, Gašparov S, Zeljko HM, and sur.. Expression of secreted frizzled-related protein 1 and 3, T-cell factor 1 and lymphoid enhancer factor 1 in clear cell renal cell carcinoma. Pathology Oncology Research [Internet]. 2013 July [cited 2024 November 30];19(3):545-551. doi: 10.1007/s12253-013-9615-3

T. Nikuševa Martić, et al., "Expression of secreted frizzled-related protein 1 and 3, T-cell factor 1 and lymphoid enhancer factor 1 in clear cell renal cell carcinoma", Pathology Oncology Research, vol. 19, no. 3, pp. 545-551, July 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:191382. [Accessed: 30 November 2024]

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Metadata
Title (english)Expression of secreted frizzled-related protein 1 and 3, T-cell factor 1 and lymphoid enhancer factor 1 in clear cell renal cell carcinoma
AuthorTamara Nikuševa-Martić
AuthorLjiljana Šerman
AuthorMartina Zeljko
AuthorŽeljko Vidas
AuthorSlavko Gašparov
AuthorHrvojka Marija Zeljko
AuthorMarin Kosović
AuthorNives Pećina-Šlaus
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Frequency and mortality of renal cell carcinoma (RCC) are increasing for decades. However, the molecular background of RCC tumorigenesis is still poorly understood. In current study we investigated the expression of TCF/LEF and SFRP family members (SFRP1 and SFRP3) to gain a better understanding of biological signaling pathways responsible for epidemiology and clinical parameters of clear cell RCC (cRCC). Thirty-six pairs of paraffin-embedded clear cRCC and adjacent nontumoral tissues samples using immunohistochemistry (IHC) were analyzed and compared with corresponding clinicopathological parameters. Immunohistochemistry indicated statistically significant decreased SFRP3 expression in tumor tissues but no consistency in SFRP1 expression in analyzed normal and tumor tissue. The TCF1 expression level was significantly weaker in normal tissue compared to tumor samples while LEF1 protein levels were significantly weaker in tumor tissue. To our knowledge, this is the first report on analysis of the expression of transcription factors TCF1 and LEF1 in clear cell renal cell carcinoma and their comparison with Wnt signal pathway antagonists belonging to SFRP family.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titlePathology Oncology Research
Numberingvol. 19, no. 3, pp. 545-551
p-ISSN1219-4956
DOIhttps://doi.org/10.1007/s12253-013-9615-3
URN:NBNurn:nbn:hr:105:191382
Publication2013-07
Document URLhttps://doi.org/10.1007/s12253-013-9615-3
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:13:31