prikaz prve stranice dokumenta Possible target for preventing fibrotic scar formation following acute myocardial infarction
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Scientific paper - Original scientific paper
Possible target for preventing fibrotic scar formation following acute myocardial infarction
Medical Hypotheses, 83 (2014), 6; 656-658. https://doi.org/10.1016/j.mehy.2014.09.011
Cvjetičanin, Bruno; Prutki, Maja; Dumić-Čule, Ivo; Veir, Zoran; Grgurević, Lovorka; Vukičević, Slobodan

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Cvjetičanin, B., Prutki, M., Dumić Čule, I., Veir, Z., Grgurević, L. & Vukičević, S. (2014). Possible target for preventing fibrotic scar formation following acute myocardial infarction. Medical Hypotheses, 83. (6), 656-658. doi: 10.1016/j.mehy.2014.09.011

Cvjetičanin, Bruno, et al. "Possible target for preventing fibrotic scar formation following acute myocardial infarction." Medical Hypotheses, vol. 83, no. 6, 2014, pp. 656-658. https://doi.org/10.1016/j.mehy.2014.09.011

Cvjetičanin, Bruno, Maja Prutki, Ivo Dumić Čule, Zoran Veir, Lovorka Grgurević and Slobodan Vukičević. "Possible target for preventing fibrotic scar formation following acute myocardial infarction." Medical Hypotheses 83, no. 6 (2014): 656-658. https://doi.org/10.1016/j.mehy.2014.09.011

Cvjetičanin, B., et al. (2014) 'Possible target for preventing fibrotic scar formation following acute myocardial infarction', Medical Hypotheses, 83(6), pp. 656-658. doi: 10.1016/j.mehy.2014.09.011

Cvjetičanin B, Prutki M, Dumić Čule I, Veir Z, Grgurević L, Vukičević S. Possible target for preventing fibrotic scar formation following acute myocardial infarction. Medical Hypotheses [Internet]. 2014 December [cited 2024 December 20];83(6):656-658. doi: 10.1016/j.mehy.2014.09.011

B. Cvjetičanin, M. Prutki, I. Dumić Čule, Z. Veir, L. Grgurević and S. Vukičević, "Possible target for preventing fibrotic scar formation following acute myocardial infarction", Medical Hypotheses, vol. 83, no. 6, pp. 656-658, December 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:934431. [Accessed: 20 December 2024]

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Metadata
Title (english)Possible target for preventing fibrotic scar formation following acute myocardial infarction
AuthorBruno Cvjetičanin
AuthorMaja Prutki
AuthorIvo Dumić-Čule
AuthorZoran Veir
AuthorLovorka Grgurević
AuthorSlobodan Vukičević
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Bone morphogenetic protein 1 (BMP1) was originally isolated from bone with other BMPs due to its affinity for heparin. While all other BMPs are members of the Transforming Growth Factor β (TGFβ) superfamily of growth factors, BMP1 is not an authentic member of the BMP protein family. Together with mammalian Tolloid Like protein 1 (mTLL-1) and mTLL-2, BMP1 comprise a small group of zinc- and calcium-dependent proteinases. Acute myocardial infarction (AMI) is the leading cause of death in developed countries which accounts for 13% of deaths worldwide. It was recently shown that inhibition of BMP1-3 reduces progression of fibrosis in chronic kidney disease and suggested that BMP1-3 is an important molecule for fibrogenesis. We hypothesize that inhibition of BMP1-3 represents future of therapeutic interventions in the heart tissue fibrosis following AMI. This novel approach aims to acquire the first candidate specific treatment for recuperating the heart function in patients with AMI.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleMedical Hypotheses
Numberingvol. 83, no. 6, pp. 656-658
p-ISSN0306-9877
DOIhttps://doi.org/10.1016/j.mehy.2014.09.011
URN:NBNurn:nbn:hr:105:934431
Publication2014-12
Document URLhttps://doi.org/10.1016/j.mehy.2014.09.011
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-27 20:15:22