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Scientific paper - Review paper
The rational use of animal models in the evaluation of novel bone regenerative therapies
Bone, 70 (2015); 73-86. https://doi.org/10.1016/j.bone.2014.07.010
Perić, Mihaela; Dumić-Čule, Ivo; Grčević, Danka; Matijašić, Mario; Verbanac, Donatella; Paul, Ruth; Grgurević, Lovorka; Trkulja, Vladimir; Bagi, Čedo M.; Vukičević, Slobodan

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Perić, M., Dumić Čule, I., Grčević, D., Matijašić, M., Verbanac, D., Paul, R. ... Vukičević, S. (2015). The rational use of animal models in the evaluation of novel bone regenerative therapies. Bone, 70., 73-86. doi: 10.1016/j.bone.2014.07.010

Perić, Mihaela, et al. "The rational use of animal models in the evaluation of novel bone regenerative therapies." Bone, vol. 70, 2015, pp. 73-86. https://doi.org/10.1016/j.bone.2014.07.010

Perić, Mihaela, Ivo Dumić Čule, Danka Grčević, Mario Matijašić, Donatella Verbanac, Ruth Paul, Lovorka Grgurević, Vladimir Trkulja, Čedo M. Bagi and Slobodan Vukičević. "The rational use of animal models in the evaluation of novel bone regenerative therapies." Bone 70 (2015): 73-86. https://doi.org/10.1016/j.bone.2014.07.010

Perić, M., et al. (2015) 'The rational use of animal models in the evaluation of novel bone regenerative therapies', Bone, 70, pp. 73-86. doi: 10.1016/j.bone.2014.07.010

Perić M, Dumić Čule I, Grčević D, Matijašić M, Verbanac D, Paul R, and sur.. The rational use of animal models in the evaluation of novel bone regenerative therapies. Bone [Internet]. 2015 January [cited 2024 December 20];70:73-86. doi: 10.1016/j.bone.2014.07.010

M. Perić, et al., "The rational use of animal models in the evaluation of novel bone regenerative therapies", Bone, vol. 70, pp. 73-86, January 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:459882. [Accessed: 20 December 2024]

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Metadata
Title (english)The rational use of animal models in the evaluation of novel bone regenerative therapies
AuthorMihaela Perić
AuthorIvo Dumić-Čule
AuthorDanka Grčević
AuthorMario Matijašić
AuthorDonatella Verbanac
AuthorRuth Paul
AuthorLovorka Grgurević
AuthorVladimir Trkulja
AuthorČedo M. Bagi
AuthorSlobodan Vukičević
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Bone has a high potential for endogenous self-repair. However, due to population aging, human diseases with impaired bone regeneration are on the rise. Current strategies to facilitate bone healing include various biomolecules, cellular therapies, biomaterials and different combinations of these. Animal models for testing novel regenerative therapies remain the gold standard in pre-clinical phases of drug discovery and development. Despite improvements in animal experimentation, excessive poorly designed animal studies with inappropriate endpoints and inaccurate conclusions are being conducted. In this review, we discuss animal models, procedures, methods and technologies used in bone repair studies with the aim to assist investigators in planning and performing scientifically sound experiments that respect the wellbeing of animals. In the process of designing an animal study for bone repair investigators should consider: skeletal characteristics of the selected animal species; a suitable animal model that mimics the intended clinical indication; an appropriate assessment plan with validated methods, markers, timing, endpoints and scoring systems; relevant dosing and statistically pre-justified sample sizes and evaluation methods; synchronization of the study with regulatory requirements and additional evaluations specific to cell-based approaches. This article is part of a Special Issue entitled "Stem Cells and Bone".
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleBone
Numberingvol. 70, pp. 73-86
p-ISSN8756-3282
DOIhttps://doi.org/10.1016/j.bone.2014.07.010
URN:NBNurn:nbn:hr:105:459882
Publication2015-01
Document URLhttps://doi.org/10.1016/j.bone.2014.07.010
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:03:01