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Scientific paper - Original scientific paper
The lack of association between components of metabolic syndrome and treatment resistance in depression
Psychopharmacology, 230 (2013), 1; 15-21. https://doi.org/10.1007/s00213-013-3085-x
Šagud, Marina; Mihaljević-Peleš, Alma; Uzun, Suzana; Vuksan Ćusa, Bjanka; Kozumplik, Oliver; Kudlek-Mikulić, Suzan; Mustapić, Maja; Barišić, Ivan; Muck-Šeler, Dorotea; Pivac, Nela

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Šagud, M., Mihaljević Peleš, A., Uzun, S., Vuksan Ćusa, B., Kozumplik, O., Kudlek Mikulić, S. ... Pivac, N. (2013). The lack of association between components of metabolic syndrome and treatment resistance in depression. Psychopharmacology, 230. (1), 15-21. doi: 10.1007/s00213-013-3085-x

Šagud, Marina, et al. "The lack of association between components of metabolic syndrome and treatment resistance in depression." Psychopharmacology, vol. 230, no. 1, 2013, pp. 15-21. https://doi.org/10.1007/s00213-013-3085-x

Šagud, Marina, Alma Mihaljević Peleš, Suzana Uzun, Bjanka Vuksan Ćusa, Oliver Kozumplik, Suzan Kudlek Mikulić, Maja Mustapić, Ivan Barišić, Dorotea Muck Šeler and Nela Pivac. "The lack of association between components of metabolic syndrome and treatment resistance in depression." Psychopharmacology 230, no. 1 (2013): 15-21. https://doi.org/10.1007/s00213-013-3085-x

Šagud, M., et al. (2013) 'The lack of association between components of metabolic syndrome and treatment resistance in depression', Psychopharmacology, 230(1), pp. 15-21. doi: 10.1007/s00213-013-3085-x

Šagud M, Mihaljević Peleš A, Uzun S, Vuksan Ćusa B, Kozumplik O, Kudlek Mikulić S, and sur.. The lack of association between components of metabolic syndrome and treatment resistance in depression. Psychopharmacology [Internet]. 2013 November [cited 2024 April 28];230(1):15-21. doi: 10.1007/s00213-013-3085-x

M. Šagud, et al., "The lack of association between components of metabolic syndrome and treatment resistance in depression", Psychopharmacology, vol. 230, no. 1, pp. 15-21, November 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:974038. [Accessed: 28 April 2024]

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Metadata
Title (english)The lack of association between components of metabolic syndrome and treatment resistance in depression
AuthorMarina Šagud
AuthorAlma Mihaljević-Peleš
AuthorSuzana Uzun
AuthorBjanka Vuksan Ćusa
AuthorOliver Kozumplik
AuthorSuzan Kudlek-Mikulić
AuthorMaja Mustapić
AuthorIvan Barišić
AuthorDorotea Muck-Šeler
AuthorNela Pivac
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
RATIONALE: Although a number of studies investigated the link between major depressive disorder (MDD) and metabolic syndrome (MetS), the association between MetS and treatment-resistant depression (TRD) is still not clear. ----- OBJECTIVES: The aim of the study was to investigate the relationship between TRD and MetS and/or components of MetS and cardiovascular risk factors. Given the high prevalence of both conditions, the hypothesis was that TRD would be significantly associated with MetS. ----- METHODS: This cross-sectional study included 203 inpatients with MDD, assessed for the treatment resistance, MetS and its components, and severity of MDD. Diagnoses and evaluations were made with SCID based on DSM-IV, National Cholesterol Education Program Adult Treatment Panel III criteria, and the Hamilton Depression Rating Scale. ----- RESULTS: TRD prior to study entry was found in 26.1 % of patients, while MetS was observed in 33.5 % of patients. The prevalence of MetS did not differ significantly between TRD and non-TRD patients. In addition, the frequency of the altered values of particular components of the MetS or cardiovascular risk factors was not associated with treatment resistance in depressed patients. Patients with TRD were older, had a higher number of lifetime episodes of depression and suicide attempts, and longer duration of MDD compared to non-TRD patients. ----- CONCLUSIONS: The occurrence of either MetS or the particular components of the MetS and other cardiovascular risk factors was similar between TRD and non-TRD patients. Although there is a bidirectional relationship between depression and MetS, neither MetS nor its components appear to influence treatment resistance to antidepressants.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titlePsychopharmacology
Numberingvol. 230, no. 1, pp. 15-21
p-ISSN0033-3158
DOIhttps://doi.org/10.1007/s00213-013-3085-x
URN:NBNurn:nbn:hr:105:974038
Publication2013-11
Document URLhttps://doi.org/10.1007/s00213-013-3085-x
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:04:14