prikaz prve stranice dokumenta Expression of growth hormone receptor, plakoglobin and NEDD9 protein in association with tumour progression and metastasis in human breast cancer
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Scientific paper - Original scientific paper
Expression of growth hormone receptor, plakoglobin and NEDD9 protein in association with tumour progression and metastasis in human breast cancer
Tumor Biology, 35 (2014), 7; 6425-6434. https://doi.org/10.1007/s13277-014-1827-y
Štajduhar, Emil; Sedić, Mirela; Leniček, Tanja; Radulović, Petra; Kerenji, Aleksandar; Krušlin, Božo; Pavelić, Krešimir; Kraljević Pavelić, Sandra

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Štajduhar, E., Sedić, M., Leniček, T., Radulović, P., Kerenji, A., Krušlin, B. ... Kraljević Pavelić, S. (2014). Expression of growth hormone receptor, plakoglobin and NEDD9 protein in association with tumour progression and metastasis in human breast cancer. Tumor Biology, 35. (7), 6425-6434. doi: 10.1007/s13277-014-1827-y

Štajduhar, Emil, et al. "Expression of growth hormone receptor, plakoglobin and NEDD9 protein in association with tumour progression and metastasis in human breast cancer." Tumor Biology, vol. 35, no. 7, 2014, pp. 6425-6434. https://doi.org/10.1007/s13277-014-1827-y

Štajduhar, Emil, Mirela Sedić, Tanja Leniček, Petra Radulović, Aleksandar Kerenji, Božo Krušlin, Krešimir Pavelić and Sandra Kraljević Pavelić. "Expression of growth hormone receptor, plakoglobin and NEDD9 protein in association with tumour progression and metastasis in human breast cancer." Tumor Biology 35, no. 7 (2014): 6425-6434. https://doi.org/10.1007/s13277-014-1827-y

Štajduhar, E., et al. (2014) 'Expression of growth hormone receptor, plakoglobin and NEDD9 protein in association with tumour progression and metastasis in human breast cancer', Tumor Biology, 35(7), pp. 6425-6434. doi: 10.1007/s13277-014-1827-y

Štajduhar E, Sedić M, Leniček T, Radulović P, Kerenji A, Krušlin B, and sur.. Expression of growth hormone receptor, plakoglobin and NEDD9 protein in association with tumour progression and metastasis in human breast cancer. Tumor Biology [Internet]. 2014 July [cited 2024 December 23];35(7):6425-6434. doi: 10.1007/s13277-014-1827-y

E. Štajduhar, et al., "Expression of growth hormone receptor, plakoglobin and NEDD9 protein in association with tumour progression and metastasis in human breast cancer", Tumor Biology, vol. 35, no. 7, pp. 6425-6434, July 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:856670. [Accessed: 23 December 2024]

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Title (english)Expression of growth hormone receptor, plakoglobin and NEDD9 protein in association with tumour progression and metastasis in human breast cancer
AuthorEmil Štajduhar
AuthorMirela Sedić
AuthorTanja Leniček
AuthorPetra Radulović
AuthorAleksandar Kerenji
AuthorBožo Krušlin
AuthorKrešimir Pavelić
AuthorSandra Kraljević Pavelić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer-related deaths among female population worldwide. Metastases are the common cause of morbidity and mortality in breast cancer and can remain latent for several years after surgical removal of the primary tumour. Thus, the identification and functional characterisation of molecular factors that promote oncogenic signalling in mammary tumour development and progression could provide new entry points for designing targeted therapeutic strategies for metastatic breast cancer. In the present study, we investigated the expression of proteins involved in cell signalling (growth hormone receptor (GHR) and NEDD9) and cell-cell adhesion (plakoglobin) in epithelial and stromal compartments of primary ductal invasive breast carcinomas and their axillary lymph node metastases versus non-metastatic tumours. Obtained data revealed remarkable increase in the expression levels of GHR and NEDD9 proteins in both epithelial and stromal components of axillary lymph node metastases in comparison with those of non-metastatic tumours, suggesting that the expression of these two proteins may provide biomarkers for tumour aggressiveness.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleTumor Biology
Numberingvol. 35, no. 7, pp. 6425-6434
p-ISSN1010-4283
DOIhttps://doi.org/10.1007/s13277-014-1827-y
URN:NBNurn:nbn:hr:105:856670
Publication2014-07
Document URLhttps://doi.org/10.1007/s13277-014-1827-y
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:14:04