Advances in a rapidly emerging field of hair follicle stem cell research

Professional paper - Review paper

• Title (croatian): Napredak u polju istraživanja matičnih stanica dlačnoga folikula
• Author: Zrinka Bukvić Mokos
• Author: Elvira Lazić Mosler
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

Human skin maintains the ability to regenerate during adulthood, as it constantly renews itself throughout adult life, and the hair follicle (HF) undergoes a perpetual cycle of growth and degeneration. The study of stem cells (SCs) in the epidermis and skin tissue engineering is a rapidly emerging field, where advances have been made in both basic and clinical research. Advances in basic science include the ability to assay SCs of the epidermis in vivo, identification of an independent interfollicular epidermal SC, and improved ability to analyze individual SCs divisions, as well as the recent hair organ regeneration via the bioengineered hair follicular unit transplantation (FUT) in mice. Advances in the clinic include recognition of the importance of SCs for wound repair and for gene therapy in inherited skin diseases, for example epidermolysis bullosa. The study of the HF stem cells (HFSCs) started by identification of epidermal SC in the HF bulge as quiescent "label retaining cells". The research of these cells emerged rapidly after the identification of bulge cell molecular markers, such as keratin 15 (K15) and CD34 in mice and CD200 in humans, which allowed the isolation and characterization of bulge cells from follicles. This paper provides an overview of the current knowledge on epidermal SCs in the HF describing their essential characteristics and the control of follicle SCs fate, their role in alopecia, as well as their use in tissue engineering.

Abstract (croatian)

Koža odrasle osobe zadržava sposobnost regeneracije, s obzirom da se trajno obnavlja tijekom odrasle dobi, a dlačni
folikuli neprekidno prolaze kroz ciklus rasta i degeneracije. Istraživanje epidermalnih matičnih stanica i inženjering
kožnoga tkiva je polje u kojemu je u zadnje vrijeme došlo do značajnih napredaka kako u bazičnim, tako i u kliničkim
istraživanjima. Napretci bazičnih istraživanja uključuju mogućnost istraživanja epidermalnih matičnih stanica in vivo,
prepoznavanje nezavisnih interfolikularnih epidermalnih matičnih stanica, bolju sposobnost analize pojedinih dioba
matičnih stanica, kao i nedavno uspjelu regeneraciju dlačnoga organa putem transplantacije bioinženjeringom stvorene
dlačne jedinice u miševa (FUT, prema engl. follicular unit transplantation). Napredak u kliničkim istraživanjima uključuje prepoznavanje važnosti epidermalnih matičnih stanica u cijeljenju rane, kao i u genskoj terapiji nasljednih bolesti
kože, kao što je npr. bulozna epidermoliza. Istraživanje folikularnih matičnih stanica započeto je identifikacijom epidermalnih
matičnih stanica kao nijemih stanica koje zadržavaju biljeg (LRC, prema engl. label retaining cells) u izbočini
dlačnoga folikula. Istraživanje ovih stanica ubrzano se razvilo nakon utvrđivanja specifičnih molekularnih biljega stanica
izbočine dlačnoga folikula, kao što su keratin 15 (K15) i CD34 u miševa, te CD200 u ljudi, jer su oni omogućili
izolaciju i utvrđivanje značajki stanica izbočine iz dlačnih folikula. U ovome članku donosimo pregled dosadašnjih spoznaja
o folikularnim epidermalnim matičnim stanicama, opisujući njihove temeljne značajke, način regulacije njihova
usmjeravanja, ulogu u alopeciji, te mogućnosti njihova korištenja u tkivnom inženjeringu.

• Keywords (english): Alopecia/therapy; Animals; Epidermis/cytology; Hair Follicle/cytology; Humans; Regenerative Medicine/trends; Stem Cells/cytology
• Language: english
• Publication type: Professional paper - Review paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Collegium Antropologicum
• Numbering: vol. 38, no. 1, pp. 373-378
• p-ISSN: 0350-6134
• URN:NBN: urn:nbn:hr:105:865549
• Publication: 2014-03
• Document URL: https://hrcak.srce.hr/120928
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 08:16:10