Gastroenteropancreatic neuroendocrine tumour arising in Meckel's diverticulum coexisting with colon adenocarcinoma

Scientific paper - Original scientific paper

• Author: Darko Katalinić
• Author: Fedor Šantek
• Author: Antonio Juretić
• Author: Dinko Škegro
• Author: Stjepko Pleština
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

Although colon cancer is the third most common cause of cancer-related death worldwide, the prevalence of gastroenteropancreatic neuroendocrine tumours (GEP-NETs) remains rare. To date, very few cases of GEP-NETs within Meckel's diverticulum and synchronous colorectal cancer have been reported. Although the coexistence of these two tumour types is uncommon, it is important to be aware of their disease patterns. We present a rare case of a patient with an intestinal GEP-NET arising in Meckel's diverticulum coexisting with metastatic colon adenocarcinoma, and we discuss the clinical manifestations and the diagnostic procedures and treatment modalities used. This case report underlines the importance of being aware of this particular coexistence, as well as the unlikely metastatic spread of GEP-NETs and the importance of a multidisciplinary approach to cancer treatment. Finally, individualizing the treatment according to the stages of the primaries will result in durable cancer control, particularly in synchronous double malignancy.

• Keywords (english): Adenocarcinoma/secondary; Adenocarcinoma/surgery; Colonic Neoplasms/pathology; Colonic Neoplasms/surgery; Humans; Intestinal Neoplasms/secondary; Intestinal Neoplasms/surgery; Male; Meckel Diverticulum/pathology; Meckel Diverticulum/surgery; Middle Aged; Neoplasm Staging; Neoplasms, Multiple Primary/pathology; Neoplasms, Multiple Primary/surgery; Neuroendocrine Tumors/secondary; Neuroendocrine Tumors/surgery; Pancreatic Neoplasms/secondary; Pancreatic Neoplasms/surgery; Prognosis; Stomach Neoplasms/secondary; Stomach Neoplasms/surgery
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: World Journal of Surgical Oncology
• Numbering: vol. 12, p. 358
• p-ISSN: 1477-7819
• DOI: https://doi.org/10.1186/1477-7819-12-358
• URN:NBN: urn:nbn:hr:105:704955
• Publication: 2014-11-27
• Document URL: http://doi.org/10.1186/1477-7819-12-358
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 08:17:19