prikaz prve stranice dokumenta Nop2 is expressed during proliferation of neural stem cells and in adult mouse and human brain
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Scientific paper - Original scientific paper
Nop2 is expressed during proliferation of neural stem cells and in adult mouse and human brain
Brain Research, 1597 (2015); 65-76. https://doi.org/10.1016/j.brainres.2014.11.040
Kosi, Nina; Alić, Ivan; Kolačević, Matea; Vrsaljko, Nina; Jovanov Milošević, Nataša; Sobol, Margarita; Philimonenko, Anatoly; Hozák, Pavel; Gajović, Srećko; Pochet, Roland; Mitrečić, Dinko

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Kosi, N., Alić, I., Kolačević, M., Vrsaljko, N., Jovanov Milošević, N., Sobol, M. ... Mitrečić, D. (2015). Nop2 is expressed during proliferation of neural stem cells and in adult mouse and human brain. Brain Research, 1597., 65-76. doi: 10.1016/j.brainres.2014.11.040

Kosi, Nina, et al. "Nop2 is expressed during proliferation of neural stem cells and in adult mouse and human brain." Brain Research, vol. 1597, 2015, pp. 65-76. https://doi.org/10.1016/j.brainres.2014.11.040

Kosi, Nina, Ivan Alić, Matea Kolačević, Nina Vrsaljko, Nataša Jovanov Milošević, Margarita Sobol, Anatoly Philimonenko, et al. "Nop2 is expressed during proliferation of neural stem cells and in adult mouse and human brain." Brain Research 1597 (2015): 65-76. https://doi.org/10.1016/j.brainres.2014.11.040

Kosi, N., et al. (2015) 'Nop2 is expressed during proliferation of neural stem cells and in adult mouse and human brain', Brain Research, 1597, pp. 65-76. doi: 10.1016/j.brainres.2014.11.040

Kosi N, Alić I, Kolačević M, Vrsaljko N, Jovanov Milošević N, Sobol M, and sur.. Nop2 is expressed during proliferation of neural stem cells and in adult mouse and human brain. Brain Research [Internet]. 2015 February 09 [cited 2024 April 11];1597:65-76. doi: 10.1016/j.brainres.2014.11.040

N. Kosi, et al., "Nop2 is expressed during proliferation of neural stem cells and in adult mouse and human brain", Brain Research, vol. 1597, pp. 65-76, February 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:794167. [Accessed: 11 April 2024]

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Metadata
Title (english)Nop2 is expressed during proliferation of neural stem cells and in adult mouse and human brain
AuthorNina Kosi
AuthorIvan Alić
AuthorMatea Kolačević
AuthorNina Vrsaljko
AuthorNataša Jovanov Milošević
AuthorMargarita Sobol
AuthorAnatoly Philimonenko
AuthorPavel Hozák
AuthorSrećko Gajović
AuthorRoland Pochet
AuthorDinko Mitrečić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The nucleolar protein 2 gene encodes a protein specific for the nucleolus. It is assumed that it plays a role in the synthesis of ribosomes and regulation of the cell cycle. Due to its link to cell proliferation, higher expression of Nop2 indicates a worse tumor prognosis. In this work we used Nop2(gt1gaj) gene trap mouse strain. While lethality of homozygous animals suggested a vital role of this gene, heterozygous animals allowed the detection of expression of Nop2 in various tissues, including mouse brain. Histochemistry, immunohistochemistry and immunoelectron microscopy techniques, applied to a mature mouse brain, human brain and on mouse neural stem cells revealed expression of Nop2 in differentiating cells, including astrocytes, as well as in mature neurons. Nop2 was detected in various regions of mouse and human brain, mostly in large pyramidal neurons. In the human, Nop2 was strongly expressed in supragranular and infragranular layers of the somatosensory cortex and in layer III of the cingulate cortex. Also, Nop2 was detected in CA1 and the subiculum of the hippocampus. Subcellular analyses revealed predominant location of Nop2 within the dense fibrillar component of the nucleolus. To test if Nop2 expression correlates to cell proliferation occurring during tissue regeneration, we induced strokes in mice by middle cerebral artery occlusion. Two weeks after stroke, the number of Nop2/nestin double positive cells in the region affected by ischemia and the periventricular zone substantially increased. Our findings suggest a newly discovered role of Nop2 in both mature neurons and in cells possibly involved in the regeneration of nervous tissue.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBrain Research
Numberingvol. 1597, pp. 65-76
p-ISSN0006-8993
DOIhttps://doi.org/10.1016/j.brainres.2014.11.040
URN:NBNurn:nbn:hr:105:794167
Publication2015-02-09
Document URLhttps://doi.org/10.1016/j.brainres.2014.11.040
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:20:52