North vs south differences in acute peptic ulcer hemorrhage in Croatia: hospitalization incidence trends, clinical features, and 30-day case fatality

Scientific paper - Original scientific paper

• Author: Neven Ljubičić
• Author: Tajana Pavić
• Author: Ivan Budimir
• Author: Željko Puljiz
• Author: Alen Bišćanin
• Author: Andre Bratanić
• Author: Marko Nikolić
• Author: Davor Hrabar
• Author: Branko Troskot
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

AIM
To assess the seven-year trends of hospitalization incidence due to acute peptic ulcer hemorrhage (APUH) and associated risk factors, and examine the differences in these trends between two regions in Croatia.
----- METHODS
The study collected sociodemographic, clinical, and endoscopic data on 2204 patients with endoscopically confirmed APUH who were admitted to the Clinical Hospital Center "Sestre Milosrdnice," Zagreb and Clinical Hospital Center Split between January 1, 2005 and December 31, 2011. We determined hospitalization incidence rates, 30-day case fatality rate, clinical outcomes, and incidence-associated factors.
----- RESULTS
No differences were observed in APUH hospitalization incidence rates between the regions. Age-standardized one-year cumulative APUH hospitalization incidence rate calculated using the European Standard Population was significantly higher in Zagreb than in Split region (43.2/100 000 vs 29.2/100,000). A significantly higher APUH hospitalization incidence rates were observed in the above 65 years age group. Overall 30-day case fatality rate was 4.9%.
----- CONCLUSION
The hospitalization incidence of APUH in two populations did not change over the observational period and it was significantly higher in the Zagreb region. The incidence of acute duodenal ulcer hemorrhage also remained unchanged, whereas the incidence of acute gastric ulcer hemorrhage increased. The results of this study allow us to monitor epidemiological indicators of APUH and compare data with other countries.

Abstract (croatian)

Razlike između sjevera i juga u incidenciji akutnog krvarenja iz peptičnog vrijeda u Hrvatskoj: trendovi incidencije hospitalizacije, kliničke osobine i 30-dnevna smrtnost -----
Cilj: Odrediti sedmogodišnje trendove incidencije hospitalizacije zbog akutnog krvarenja iz peptičnog vrijeda i povezane rizične čimbenike te ispitati razlike u ovim trendovima između dvije regije u Hrvatskoj.
----- Postupci: Prikupili smo sociodemografske, kliničke i endoskopske podatke o 2204 pacijenta s endoskopski potvrđenim akutnim krvarenjem iz peptičnog vrijeda koji su primljeni u Klinički bolnički centar „Sestre Milosrdnice” u Zagrebu i Klinički bolnički centar Split između 1. siječnja 2005. i 31. prosinca 2011. Izračunali smo stope incidencije hospitalizacije, kliničke ishode i čimbenike povezane s incidencijom.
----- Rezultati: Nije bilo razlika u stopi incidencije hospitalizacije između regija. Jednogodišnja kumulativna stopa incidencije hospitalizacije standardizirana po dobi izračunata uz pomoć Europske standardne populacije bila je značajno viša u zagrebačkoj nego u splitskoj regiji (43,2/100 000 vs 29,2/100 000). Značajno više stope incidencije hospitalizacije zabilježene su u dobnoj skupini iznad 65 godina. Ukupna 30-dnevna smrtnost bila je 4,9%.
----- Zaključak: Incidencija hospitalizacije zbog akutnog krvarenja iz peptičnog vrijeda u obje populacije nije se promijenila u ispitivanom razdoblju i bila je značajno viša u zagrebačkoj regiji. Incidencija akutnog krvarenja iz vrijeda dvanaesnika također se nije promijenila, dok je incidencija akutnog krvarenja iz želučanog vrijeda porasla. Rezultati ovog istraživanja omogućuju praćenje epidemioloških pokazatelja akutnog krvarenja iz peptičnog vrijeda i usporedbu podataka s drugim državama.

• Keywords (english): 2-Pyridinylmethylsulfinylbenzimidazoles/therapeutic use; Acute Disease; Administration, Oral; Age Distribution; Aged; Aged, 80 and over; Anti-Ulcer Agents/therapeutic use; Croatia/epidemiology; Epinephrine/administration & dosage; Esomeprazole/therapeutic use; Female; Geography; Hospitalization/statistics & numerical data; Humans; Incidence; Male; Middle Aged; Peptic Ulcer Hemorrhage/diagnosis; Peptic Ulcer Hemorrhage/drug therapy; Peptic Ulcer Hemorrhage/epidemiology; Risk Factors; Sex Distribution; Vasoconstrictor Agents/administration & dosage
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Croatian Medical Journal
• Numbering: vol. 55, no. 6, pp. 647-654
• p-ISSN: 0353-9504
• DOI: https://doi.org/10.3325/cmj.2014.55.647
• URN:NBN: urn:nbn:hr:105:853188
• Publication: 2014-12
• Document URL: https://doi.org/10.3325/cmj.2014.55.647
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 08:26:00