Influence of diastolic blood pressure on glaucoma progression in glaucoma patients with systemic hypertension

Scientific paper - Original scientific paper

• Title (croatian): Utjecaj dijastoličkog krvnog tlaka na progresiju glaukoma kod pacijenata s glaukomom i sustavnom hipertenzijom
• Author: Smiljka Popović Suić
• Author: Ivan Škegro
• Author: Sonja Jandroković
• Author: Rajko Kordić
• Author: Marija Barišić Kutija
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

The aim of this study is to determine relationship between glaucoma progression and diastolic blood pressure. It was conducted on 64 glaucoma patients at the Department of Ophthalmology of Clinical Hospital Centre Zagreb in three years period. The patients were on anti glaucoma therapy and had mean intraocular pressure values under 20 mmHg. At the same time they were on antihypertensive drug therapy. Patients were classified according Glaucoma Staging System based on the perimetric indices mean deviation (MD) and Pattern Standard Deviation into stage 2-4 (moderate glaucoma) at baseline. Rate of visual field progression was calculated in db/year for MD in the last three visits. Patients were divided in 3 groups according to progression--stabile, moderate and progressive. There was no statistically significant difference between 3 groups in terms of intraocular pressure values at baseline and in follow up period. After reviewing their blood pressure, the progressive group showed a significantly lower diastolic blood pressure compared to both stable group and the group with moderate progression. There was no statistical difference between the group with moderate progression and the stable group in terms of diastolic blood pressure. Results suggest that greater risk of glaucoma progression is connected with lower diastolic blood pressure. Diastolic pressure values could be important as one of the risk factors for progression in glaucoma patients with controlled intraocular pressure values.

Abstract (croatian)

Cilj ove studije je utvrditi povezanost između progresije glaukoma i dijastoličkog krvnog tlaka. Studija je provedena
na 64 pacijenata s glaukomom pri Klinici za očne bolesti KBC Zagreb u trogodišnjem periodu. Pacijenti su bili na antiglaukomskoj
terapiji i imali su srednje vrijednosti očnog tlaka ispod 20 mmHg. Istovremeno su bili i na antihipertenzivnoj
medikamentoznoj terapiji. Pacijenti su u početku klasificirani prema Glaucoma Staging System, koji se zasniva
na srednjoj devijaciji perimetrijskih indeksa (MD) i Obrascu standardne devijacije, u stadij 2–4 (umjereni glaukom).
Stupanj progresije vidnog polja je izračunat u db/godina za MD u posljednja tri posjeta. Pacijenti su podijeljeni u tri
skupine – stabilni, umjereni i progresivni. Nije nađena statistički značajna razlika između tri skupine u odnosu na očni
tlak u početku i periodu praćenja. Nakon analiziranja njihovog krvnog tlaka, progresivna skupina pokazala je značajno
niži dijastolički krvni tlak u odnosu na stabilnu i skupinu s umjerenom progresijom. Nije bilo statističke razlike između
skupine s umjerenom progresijom i stabilne skupine u odnosu na dijastolički krvni tlak. Rezultati upućuju na to da je
veći rizik od progresije glaukoma povezan s nižim dijastoličkim krvnim tlakom. Vrijednosti dijastoličkog krvnog tlaka
mogle bi biti značajne kao jedan od čimbenika rizika za progresiju kod pacijenata s glaukomom i kontroliranim vrijednostima
očnog tlaka.

• Keywords (english): Aged; Blood Pressure; Diastole; Disease Progression; Female; Glaucoma / complications; Glaucoma / physiopathology; Humans; Hypertension / complications; Hypertension / physiopathology; Intraocular Pressure; Male; Middle Aged; Risk Factors; Severity of Illness Index; Tonometry, Ocular; Visual Field Tests; Visual Fields
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Collegium Antropologicum
• Numbering: vol. 39, no. 3, pp. 719-722
• p-ISSN: 0350-6134
• URN:NBN: urn:nbn:hr:105:403450
• Publication: 2015-09
• Document URL: https://hrcak.srce.hr/166286
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 08:30:16