prikaz prve stranice dokumenta Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies
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Scientific paper - Original scientific paper
Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies
Biomolecules, 6 (2016), 1; 6. https://doi.org/10.3390/biom6010006
Šimić, Goran; Babić Leko, Mirjana; Wray, Selina; Harrington, Charles; Delalle, Ivana; Jovanov-Milošević, Nataša; Bažadona, Danira; Buée, Luc; de Silva, Rohan; Di Giovanni, Giuseppe; Wischik, Claude; Hof, Patrick R.

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Šimić, G., Babić Leko, M., Wray, S., Harrington, C., Delalle, I., Jovanov Milošević, N. ... Hof, P. R. (2016). Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies. Biomolecules, 6. (1), 6. doi: 10.3390/biom6010006

Šimić, Goran, et al. "Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies." Biomolecules, vol. 6, no. 1, 2016, p. 6. https://doi.org/10.3390/biom6010006

Šimić, Goran, Mirjana Babić Leko, Selina Wray, Charles Harrington, Ivana Delalle, Nataša Jovanov Milošević, Danira Bažadona, et al. "Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies." Biomolecules 6, no. 1 (2016): 6. https://doi.org/10.3390/biom6010006

Šimić, G., et al. (2016) 'Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies', Biomolecules, 6(1), p. 6. doi: 10.3390/biom6010006

Šimić G, Babić Leko M, Wray S, Harrington C, Delalle I, Jovanov Milošević N, and sur.. Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies. Biomolecules [Internet]. 2016 January 06 [cited 2024 May 03];6(1):6. doi: 10.3390/biom6010006

G. Šimić, et al., "Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies", Biomolecules, vol. 6, no. 1, p. 6, January 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:938227. [Accessed: 03 May 2024]

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Metadata
Title (english)Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies
AuthorGoran Šimić
AuthorMirjana Babić Leko
AuthorSelina Wray
AuthorCharles Harrington
AuthorIvana Delalle
AuthorNataša Jovanov-Milošević
AuthorDanira Bažadona
AuthorLuc Buée
AuthorRohan de Silva
AuthorGiuseppe Di Giovanni
AuthorClaude Wischik
AuthorPatrick R. Hof
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Abnormal deposition of misprocessed and aggregated proteins is a common final pathway of most neurodegenerative diseases, including Alzheimer's disease (AD). AD is characterized by the extraneuronal deposition of the amyloid β (Aβ) protein in the form of plaques and the intraneuronal aggregation of the microtubule-associated protein tau in the form of filaments. Based on the biochemically diverse range of pathological tau proteins, a number of approaches have been proposed to develop new potential therapeutics. Here we discuss some of the most promising ones: inhibition of tau phosphorylation, proteolysis and aggregation, promotion of intra- and extracellular tau clearance, and stabilization of microtubules. We also emphasize the need to achieve a full understanding of the biological roles and post-translational modifications of normal tau, as well as the molecular events responsible for selective neuronal vulnerability to tau pathology and its propagation. It is concluded that answering key questions on the relationship between Aβ and tau pathology should lead to a better understanding of the nature of secondary tauopathies, especially AD, and open new therapeutic targets and strategies.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBiomolecules
Numberingvol. 6, no. 1, p. 6
p-ISSN2218-273X
DOIhttps://doi.org/10.3390/biom6010006
URN:NBNurn:nbn:hr:105:938227
Publication2016-01-06
Document URLhttps://doi.org/10.3390/biom6010006
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:33:53