Effect of extra virgin olive oil on biomarkers of inflammation in HIV-infected patients: a randomized, crossover, controlled clinical trial

Scientific paper - Original scientific paper

• Author: Sanja Kozić Dokmanović
• Author: Krunoslava Kolovrat
• Author: Renata Laškaj
• Author: Vedrana Jukić
• Author: Nada Vrkić
• Author: Josip Begovac
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

BACKGROUND:

Premature atherosclerosis in HIV-infected patients is associated with chronic infection by itself and adverse effects of antiretroviral treatment (ART). Extra virgin olive oil (EVOO) has a beneficial effect on the cardiovascular system because of its anti-inflammatory properties. The objective of this study was to determine whether the consumption of EVOO improves inflammation and atherosclerosis biomarkers in HIV-infected patients receiving ART. ----- MATERIAL AND METHODS:

This randomized, crossover, controlled trial included 39 HIV-positive male participants who consumed 50 mL of EVOO or refined olive oil (ROO) daily. Four participants dropped out of the study. Leukocyte count, erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein (hsCRP), interleukin-6, fibrinogen, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, malondialdehyde, glutathione-peroxidase, superoxide dismutase, oxidized LDL and von Willebrand factor were determined before the first and after each of the 2 intervention periods. Intervention and washout periods lasted for 20 and 14 days, respectively. ----- RESULTS:

In participants with >90% compliance (N=30), hsCRP concentrations were lower after EVOO intervention (geometric mean [GM], 1.70 mg/L; 95% confidence interval [CI], 1.15-2.52) compared to ROO administration (GM, 2.92 mg/L; 95% CI, 1.95-4.37) (p=0.035). In participants using lopinavir/ritonavir, ESR and hsCRP concentrations decreased 62% and 151%, respectively, after EVOO administration. In the whole study population (N=35) we found no difference in analyzed biomarkers after EVOO administration. ----- CONCLUSIONS:

Our exploratory study suggests that EVOO consumption could lower hsCRP in patients on ART.

• Keywords (english): Adolescent; Adult; Aged; Antiretroviral Therapy, Highly Active; Atherosclerosis / blood; Atherosclerosis / prevention & control; Biomarkers / blood; C-Reactive Protein / metabolism; Cross-Over Studies; Drug Combinations; Food Handling; HIV Infections / blood; HIV Infections / diet therapy; HIV Infections / drug therapy; HIV Protease Inhibitors / therapeutic use; Humans; Inflammation Mediators / blood; Lopinavir / therapeutic use; Male; Middle Aged; Olive Oil / administration & dosage; Olive Oil / isolation & purification; Ritonavir / therapeutic use; Single-Blind Method; Young Adult
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Medical Science Monitor
• Numbering: vol. 21, pp. 2406-2413
• p-ISSN: 1643-3750
• DOI: https://doi.org/10.12659/MSM.893881
• URN:NBN: urn:nbn:hr:105:838117
• Publication: 2015
• Document URL: https://doi.org/10.12659/MSM.893881
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 08:34:34