Which questionnaires should we use to evaluate quality of life in patients with chronic graft-vs-host disease?

Scientific paper - Original scientific paper

• Author: Zinaida Perić
• Author: Lana Desnica
• Author: Nadira Duraković
• Author: Alen Ostojić
• Author: Dražen Pulanić
• Author: Ranka Serventi-Seiwerth
• Author: Ema Prenc
• Author: Grzegorz Basak
• Author: Radovan Vrhovac
• Author: Steven Z Pavletic
• Author: Damir Nemet
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

AIM:

To investigate the ability of two standard quality of life (QOL) questionnaires - The Short Form (36-item) Health Survey (SF-36) and The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ C30) to evaluate QOL in patients with chronic graft-vs-host disease (cGVHD) graded according to National Institutes of Health (NIH) consensus criteria. -----

METHODS:

In this cross-sectional study, QOL was assessed in patients who underwent allogeneic stem cell transplantation (allo-SCT) at the University Hospital Centre Zagreb and were alive and in complete remission for more than one year after allo-SCT. -----

RESULTS:

The study included 58 patients, 38 patients with cGVHD and 20 controls, patients without cGVHD. Patients with cGVHD scored according to the NIH criteria had significantly lower scores of global health status and lower QOL on all SF-36 subscales and most of QLQ C30 functional subscales (P<0.050 for all comparisons). Furthermore, patients with active cGVHD had significantly lower QOL scores than patients with inactive cGVHD, and this difference was most evident in physical functioning subscale of SF-36 (P=0.0007) and social functioning subscale of QLQ C30 (P=0.009). -----

CONCLUSION:

cGVHD scored according to the NIH criteria is correlated with patient-reported QOL, particularly in the physical domains as detected by SF-36. QLQ C30 questionnaire adds more information on social functioning and should be used as a valuable tool in the evaluation of social domains in cGVHD patients.

Abstract (croatian)

Koje upitnike trebamo koristiti za procjenu kvalitete života pacijenata s kroničnom bolešću presatka protiv primatelja? -----
Cilj: Istražiti može li se kvaliteta života pacijenata s kroničnom bolešću presatka protiv primatelja podijeljenih prema kriterijima Američkih instituta za zdravlje (prema engl. National Institutes of Health, NIH) procjenjivati uz pomoć dva standardna upitnika – Kratke zdravstvene ankete (prema engl. The Short Form Health Survey, SF-36) i Upitnika o kvaliteti života Europske organizacije za istraživanje i liječenje raka – Osnovni upitnik 30 (prema engl. The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30, EORTC QLQ C30). -----
Postupci: U ovom presječnom istraživanju, kvaliteta života procijenjena je kod pacijenata podvrgnutih alogenoj transplantaciji matičnih stanica u Kliničkom bolničkom centru "Zagreb" te su bili živi i u potpunoj remisiji više od godinu dana nakon transplantacije. -----
Rezultati: Istraživanje je uključilo 58 pacijenata, 38 pacijenata s kroničnom bolešću presatka protiv primatelja i 20 kontrolnih ispitanika. Pacijenti s kroničnom bolešću presatka protiv primatelja prema NIH kriterijima imali su značajno niži izračun ukupnog zdravstvenog statusa i nižu kvalitetu života na svim podljestvicama SF-36 upitnika i većini funkcionalnih podljestvica QLQ C30 upitnika (P<0,050 za sve usporedbe). Pacijenti s aktivnom bolešću imali su značajno niži izračun kvalitete života nego pacijenti s neaktivnom bolešću, a ova razlika bila je najuočljivija na podljestvici fizičkog funkcioniranja SF-36 upitnika (P= 0,0007) i na podljestvici socijalnog funkcioniranja QLQ C30 upitnika (P=0,009). -----
Zaključak: Kronična bolest presatka protiv primatelja stupnjevana prema NIH kriterijima korelirala je sa samoprocijenjenom kvalitetom života, posebice u fizičkim domenama koje ispituje SF-36. QLQ C30 upitnik pružio je dodatne informacije o socijalnom funkcioniranju pacijenata i pokazao se kao vrijedan alat za procjenu socijalne domene kod pacijenata s kroničnom bolešću presatka protiv primatelja.

• Keywords (english): Adolescent; Adult; Aged; Case-Control Studies; Chronic Disease; Cross-Sectional Studies; Female; Graft vs Host Disease/etiology; Graft vs Host Disease/psychology; Health Status; Hematopoietic Stem Cell Transplantation/adverse effects; Hematopoietic Stem Cell Transplantation/psychology; Humans; Male; Middle Aged; Quality of Life/psychology; Surveys and Questionnaires; United States; Young Adult
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Accepted version
• Journal title: Croatian Medical Journal
• Numbering: vol. 57, no. 1, pp. 6-15
• p-ISSN: 0353-9504
• DOI: https://doi.org/10.3325/cmj.2016.57.6
• URN:NBN: urn:nbn:hr:105:843086
• Publication: 2016-02
• Document URL: https://doi.org/10.3325/cmj.2016.57.6
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 08:42:16