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Scientific paper - Original scientific paper
A European spectrum of pharmacogenomic biomarkers: implications for clinical pharmacogenomics
PLoS ONE, 11 (2016), 9; e0162866. https://doi.org/10.1371/journal.pone.0162866
Mizzi, Clint; Dalabira, Eleni; Kumuthini, Judit; Dzimiri, Nduna; Balogh, Istvan; Başak, Nazli; Böhm, Ruwen; Borg, Joseph; Borgiani, Paola; Božina, Nada; Bruckmueller, Henrike; Burzynska, Beata; Carracedo, Angel; Cascorbi, Ingolf; Deltas, Constantinos; Dolzan, Vita; Fenech, Anthony; Grech, Godfrey; Kasiulevicius, Vytautas; Kádaši, Ľudevít; Kučinskas, Vaidutis; Khusnutdinova, Elza; Loukas, Yiannis L.; Macek, Milan; Makukh, Halyna; Mathijssen, Ron; Mitropoulos, Konstantinos; Mitropoulou, Christina; Novelli, Giuseppe; Papantoni, Ioanna; Pavlovic, Sonja; Saglio, Giuseppe; Sertić, Jadranka; Stojiljkovic, Maja; Stubbs, Andrew P.; Squassina, Alessio; Torres, Maria; Turnovec, Marek; van Schaik, Ron H.; Voskarides, Konstantinos; Wakil, Salma M.; Werk, Anneke; del Zompo, Maria; Zukic, Branka; Katsila, Theodora; Lee, Ming Ta Michael; Motsinger-Rief, Alison; Mc Leod, Howard L.; van der Spek, Peter J.; Patrinos, George P. More authors...

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Mizzi, C., Dalabira, E., Kumuthini, J., Dzimiri, N., Balogh, I., Başak, N. ... Patrinos, G. P. (2016). A European spectrum of pharmacogenomic biomarkers: implications for clinical pharmacogenomics. PLoS ONE, 11. (9). doi: 10.1371/journal.pone.0162866

Mizzi, Clint, et al. "A European spectrum of pharmacogenomic biomarkers: implications for clinical pharmacogenomics." PLoS ONE, vol. 11, no. 9, 2016. https://doi.org/10.1371/journal.pone.0162866

Mizzi, Clint, Eleni Dalabira, Judit Kumuthini, Nduna Dzimiri, Istvan Balogh, Nazli Başak, Ruwen Böhm, et al. "A European spectrum of pharmacogenomic biomarkers: implications for clinical pharmacogenomics." PLoS ONE 11, no. 9 (2016). https://doi.org/10.1371/journal.pone.0162866

Mizzi, C., et al. (2016) 'A European spectrum of pharmacogenomic biomarkers: implications for clinical pharmacogenomics', PLoS ONE, 11(9). doi: 10.1371/journal.pone.0162866

Mizzi C, Dalabira E, Kumuthini J, Dzimiri N, Balogh I, Başak N, and sur.. A European spectrum of pharmacogenomic biomarkers: implications for clinical pharmacogenomics. PLoS ONE [Internet]. 2016 September 16 [cited 2024 November 07];11(9). doi: 10.1371/journal.pone.0162866

C. Mizzi, et al., "A European spectrum of pharmacogenomic biomarkers: implications for clinical pharmacogenomics", PLoS ONE, vol. 11, no. 9, September 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:858915. [Accessed: 07 November 2024]

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Title (english)A European spectrum of pharmacogenomic biomarkers: implications for clinical pharmacogenomics
AuthorClint Mizzi
AuthorEleni Dalabira
AuthorJudit Kumuthini
AuthorNduna Dzimiri
AuthorIstvan Balogh
AuthorNazli Başak
AuthorRuwen Böhm
AuthorJoseph Borg
AuthorPaola Borgiani
AuthorNada Božina
AuthorHenrike Bruckmueller
AuthorBeata Burzynska
AuthorAngel Carracedo
AuthorIngolf Cascorbi
AuthorConstantinos Deltas
AuthorVita Dolzan
AuthorAnthony Fenech
AuthorGodfrey Grech
AuthorVytautas Kasiulevicius
AuthorĽudevít Kádaši
AuthorVaidutis Kučinskas
AuthorElza Khusnutdinova
AuthorYiannis L. Loukas
AuthorMilan Macek
AuthorHalyna Makukh
AuthorRon Mathijssen
AuthorKonstantinos Mitropoulos
AuthorChristina Mitropoulou
AuthorGiuseppe Novelli
AuthorIoanna Papantoni
AuthorSonja Pavlovic
AuthorGiuseppe Saglio
AuthorJadranka Sertić
AuthorMaja Stojiljkovic
AuthorAndrew P. Stubbs
AuthorAlessio Squassina
AuthorMaria Torres
AuthorMarek Turnovec
AuthorRon H. van Schaik
AuthorKonstantinos Voskarides
AuthorSalma M. Wakil
AuthorAnneke Werk
AuthorMaria del Zompo
AuthorBranka Zukic
AuthorTheodora Katsila
AuthorMing Ta Michael Lee
AuthorAlison Motsinger-Rief
AuthorHoward L. Mc Leod
AuthorPeter J. van der Spek
AuthorGeorge P. Patrinos
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Pharmacogenomics aims to correlate inter-individual differences of drug efficacy and/or toxicity with the underlying genetic composition, particularly in genes encoding for protein factors and enzymes involved in drug metabolism and transport. In several European populations, particularly in countries with lower income, information related to the prevalence of pharmacogenomic biomarkers is incomplete or lacking. Here, we have implemented the microattribution approach to assess the pharmacogenomic biomarkers allelic spectrum in 18 European populations, mostly from developing European countries, by analyzing 1,931 pharmacogenomics biomarkers in 231 genes. Our data show significant inter-population pharmacogenomic biomarker allele frequency differences, particularly in 7 clinically actionable pharmacogenomic biomarkers in 7 European populations, affecting drug efficacy and/or toxicity of 51 medication treatment modalities. These data also reflect on the differences observed in the prevalence of high-risk genotypes in these populations, as far as common markers in the CYP2C9, CYP2C19, CYP3A5, VKORC1, SLCO1B1 and TPMT pharmacogenes are concerned. Also, our data demonstrate notable differences in predicted genotype-based warfarin dosing among these populations. Our findings can be exploited not only to develop guidelines for medical prioritization, but most importantly to facilitate integration of pharmacogenomics and to support pre-emptive pharmacogenomic testing. This may subsequently contribute towards significant cost-savings in the overall healthcare expenditure in the participating countries, where pharmacogenomics implementation proves to be cost-effective.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePLoS ONE
Numberingvol. 11, no. 9, e0162866
p-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0162866
URN:NBNurn:nbn:hr:105:858915
Publication2016-09-16
Document URLhttp://doi.org/10.1371/journal.pone.0162866
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:48:31