Metrics of high-density lipoprotein function and hospital mortality in acute heart failure patients

Scientific paper - Original scientific paper

• Author: Ines Potočnjak
• Author: Vesna Degoricija
• Author: Matias Trbušić
• Author: Sanda Dokoza Terešak
• Author: Bojana Radulović
• Author: Gudrun Pregartner
• Author: Andrea Berghold
• Author: Beate Tiran
• Author: Gunther Marsche
• Author: Saša Frank
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

OBJECTIVE:

The functionality of high-density lipoprotein (HDL) is impaired in chronic ischaemic heart failure (HF). However, the relationship between HDL functionality and outcomes in acute HF (AHF) has not been studied. The present study investigates whether the metrics of HDL functionality, including HDL cholesterol efflux capacity and HDL-associated paraoxonase (PON)-1 arylesterase (AE) activity are associated with hospital mortality in AHF patients. -----

METHODS AND RESULTS:

The study was performed as a prospective, single-centre, observational research on 152 patients, defined and categorised according to the ESC and ACCF/AHA Guidelines for HF by time of onset, final clinical presentation and ejection fraction. The mean age of the included patients (52% female) was 75.2 years (SD 10.3) and hospital mortality was 14.5%. HDL cholesterol efflux capacity was examined by measuring the capacity of apoB depleted serum to remove tritium-labelled cholesterol from cultured macrophages. The AE activity of the HDL fraction was examined by a photometric assay. In a univariable regression analysis, low cholesterol efflux, but not AE activity, was significantly associated with hospital mortality [odds ratio (OR) 0.78, 95% confidence interval (CI) 0.64-0.96, p = 0.019]. In multivariable analysis progressively adjusting for important clinical and laboratory parameters the association obtained for cholesterol efflux capacity and hospital mortality by univariable analysis, despite a stable OR, did not stay significant (p = 0.179). -----

CONCLUSION:

Our results suggest that HDL cholesterol efflux capacity (but not AE activity) contributes to, but is not an independent risk factor for, hospital mortality in AHF patients. Larger studies are needed to draw firm conclusions.

• Keywords (english): Acute Disease; Aged; Aged, 80 and over; Body Mass Index; Carboxylic Ester Hydrolases/blood; Cholesterol, HDL/blood; Female; Heart Failure/blood; Heart Failure/diagnosis; Heart Failure/mortality; Hospital Mortality; Humans; Lipoproteins, HDL/blood; Logistic Models; Male; Multivariate Analysis; Prospective Studies
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: PLoS ONE
• Numbering: vol. 11, no. 6, e0157507
• p-ISSN: 1932-6203
• DOI: https://doi.org/10.1371/journal.pone.0157507
• URN:NBN: urn:nbn:hr:105:131814
• Publication: 2016-06-15
• Document URL: https://doi.org/10.1371/journal.pone.0157507
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 08:50:11