Predictive value of cerebrospinal fluid visinin-like protein-1 levels for Alzheimer's disease early detection and differential diagnosis in patients with mild cognitive impairment

Scientific paper - Original scientific paper

• Author: Mirjana Babić Leko
• Author: Fran Borovečki
• Author: Nenad Dejanović
• Author: Patrick R. Hof
• Author: Goran Šimić
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Basic Medical Sciences

Abstract (english)

Visinin-like protein 1 (VILIP-1) recently emerged as a potential biomarker of Alzheimer's disease (AD). This neuronal calcium sensor protein previously used as a marker of acute ischemic stroke is elevated in the cerebrospinal fluid (CSF) of AD patients. The goal of this study was to assess CSF VILIP-1 potential in early AD diagnosis and in differentiating mild cognitive impairment (MCI) patients with and without risk of AD. Additionally, we tested VILIP-1 ability to differentiate AD from other primary causes of dementia, and predict the progression of AD-related cognitive decline. VILIP-1 levels were compared with five CSF AD biomarkers (t-tau, Aβ1-42, p-tau181, p-tau199, and p-tau231). VILIP-1 successfully differentiated two MCI patient groups characterized by absence or presence of pathological levels of these CSF biomarkers, except for t-tau. VILIP-1/Aβ(1-42) and VILIP-1/p-tau181 ratios also differentiated MCI patients with pathological CSF biomarker levels. However, there was no difference in VILIP-1 levels between AD and MCI patients. VILIP-1/Aβ(1-42) and VILIP-1/p-tau231 ratios reached high sensitivities (above 70%) and very high specificities (above 85%) in differentiating AD patients from HC. Additionally, VILIP-1 differentiated AD from patients with Lewy body disease with 77.1% sensitivity and 100% specificity. VILIP-1 potential as a prognostic biomarker of cognitive decline in AD was also proved since VILIP-1/t-tau, VILIP-1/p-tau181, and VILIP-1/p-tau231 ratios correlated with MMSE scores. These data indicate that VILIP-1 alone or in combination with other AD CSF biomarkers represent a valuable marker for the early diagnosis of AD, recognition of MCI patients at higher risk to develop dementia, and in differentiating AD from LBD.

• Keywords (english): Adult; Aged; Aged, 80 and over; Alzheimer Disease/cerebrospinal fluid; Alzheimer Disease/diagnosis; Amyloid beta-Peptides/cerebrospinal fluid; Cognitive Dysfunction/diagnosis; Diagnosis, Differential; Disease Progression; Female; Humans; Male; Mental Status Schedule; Middle Aged; Neurocalcin/cerebrospinal fluid; Peptide Fragments/cerebrospinal fluid; Predictive Value of Tests; ROC Curve; Statistics as Topic; tau Proteins/cerebrospinal fluid
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Accepted version
• Journal title: Journal of Alzheimer's Disease
• Numbering: vol. 50, no. 3, pp. 765-778
• p-ISSN: 1387-2877
• DOI: https://doi.org/10.3233/JAD-150705
• URN:NBN: urn:nbn:hr:105:599312
• Publication: 2016
• Document URL: https://doi.org/10.3233/JAD-150705
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 08:53:11