prikaz prve stranice dokumenta Inositol pyrophosphates modulate cell cycle independently of alteration in telomere length
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Scientific paper - Original scientific paper
Inositol pyrophosphates modulate cell cycle independently of alteration in telomere length
Advances in Biological Regulation, 60 (2016); 22-28. https://doi.org/10.1016/j.jbior.2015.09.003
Banfić, Hrvoje; Crljen, Vladiana; Lukinović-Škudar, Vesna; Dembitz, Vilma; Lalić, Hrvoje; Bedalov, Antonio; Višnjić, Dora

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Banfić, H., Crljen, V., Lukinović Škudar, V., Dembitz, V., Lalić, H., Bedalov, A. & Višnjić, D. (2016). Inositol pyrophosphates modulate cell cycle independently of alteration in telomere length. Advances in Biological Regulation, 60., 22-28. doi: 10.1016/j.jbior.2015.09.003

Banfić, Hrvoje, et al. "Inositol pyrophosphates modulate cell cycle independently of alteration in telomere length." Advances in Biological Regulation, vol. 60, 2016, pp. 22-28. https://doi.org/10.1016/j.jbior.2015.09.003

Banfić, Hrvoje, Vladiana Crljen, Vesna Lukinović Škudar, Vilma Dembitz, Hrvoje Lalić, Antonio Bedalov and Dora Višnjić. "Inositol pyrophosphates modulate cell cycle independently of alteration in telomere length." Advances in Biological Regulation 60 (2016): 22-28. https://doi.org/10.1016/j.jbior.2015.09.003

Banfić, H., et al. (2016) 'Inositol pyrophosphates modulate cell cycle independently of alteration in telomere length', Advances in Biological Regulation, 60, pp. 22-28. doi: 10.1016/j.jbior.2015.09.003

Banfić H, Crljen V, Lukinović Škudar V, Dembitz V, Lalić H, Bedalov A, and sur.. Inositol pyrophosphates modulate cell cycle independently of alteration in telomere length. Advances in Biological Regulation [Internet]. 2016 January [cited 2024 December 20];60:22-28. doi: 10.1016/j.jbior.2015.09.003

H. Banfić, et al., "Inositol pyrophosphates modulate cell cycle independently of alteration in telomere length", Advances in Biological Regulation, vol. 60, pp. 22-28, January 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:562422. [Accessed: 20 December 2024]

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Metadata
Title (english)Inositol pyrophosphates modulate cell cycle independently of alteration in telomere length
AuthorHrvoje Banfić
AuthorVladiana Crljen
AuthorVesna Lukinović-Škudar
AuthorVilma Dembitz
AuthorHrvoje Lalić
AuthorAntonio Bedalov
AuthorDora Višnjić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Synthesis of inositol pyrophosphates through activation of Kcs1 plays an important role in the signalling response required for cell cycle progression after mating pheromone arrest. Overexpression of Kcs1 doubled the level of inositol pyrophosphates when compared to wild type cells and 30 min following the release from α-factor block further increase in inositol pyrophosphates was observed, which resulted that cells overexpressing Kcs1 reached G2/M phase earlier than wild type cells. Similar effect was observed in ipk1Δ cells, which are unable to synthesize IP6-derived inositol pyrophosphates (IP7 and IP8) but will synthesize IP5-derived inositol pyrophosphates (PP-IP4 and (PP)2-IP3). Although ipk1Δ cells have shorter telomeres than wild type cells, overexpression of Kcs1 in both strains have similar effect on cell cycle progression. As it is known that PP-IP4 regulates telomere length through Tel1, inositol polyphosphates, cell cycle and telomere length were determined in tel1Δ cells. The release of the cells from α-factor block and overexpression of Kcs1 in tel1Δ cells produced similar effects on inositol pyrophosphates level and cell cycle progression when compared to wild type cells, although tel1Δ cells possesses shorter telomeres than wild type cells. It can be concluded that telomere length does not affect cell cycle progression, since cells with short telomeres (ipk1Δ and tel1Δ) progress through cell cycle in a similar manner as wild type cells and that overexpression of Kcs1 in cells with either short or normal telomeres will increase S phase progression without affecting telomere length. Furthermore, IP5-derived inositol pyrophosphates can compensate for the loss of IP6-derived inositol pyrophosphates, in modulating S phase progression of the cell cycle.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleAdvances in Biological Regulation
Numberingvol. 60, pp. 22-28
p-ISSN2212-4926
DOIhttps://doi.org/10.1016/j.jbior.2015.09.003
URN:NBNurn:nbn:hr:105:562422
Publication2016-01
Document URLhttps://doi.org/10.1016/j.jbior.2015.09.003
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:52:31