prikaz prve stranice dokumenta Constitutively elevated blood serotonin is associated with bone loss and type 2 diabetes in rats
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Scientific paper - Original scientific paper
Constitutively elevated blood serotonin is associated with bone loss and type 2 diabetes in rats
PLoS ONE, 11 (2016), 2; e0150102. https://doi.org/10.1371/journal.pone.0150102
Erjavec, Igor; Bordukalo-Nikšić, Tatjana; Brkljačić, Jelena; Grčević, Danka; Mokrović, Gordana; Kesić, Maja; Rogić, Dunja; Zavadoski, William; Paralkar, Vishwas M.; Grgurević, Lovorka; Trkulja, Vladimir; Čičin-Šain, Lipa; Vukičević, Slobodan

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Erjavec, I., Bordukalo Nikšić, T., Brkljačić, J., Grčević, D., Mokrović, G., Kesić, M. ... Vukičević, S. (2016). Constitutively elevated blood serotonin is associated with bone loss and type 2 diabetes in rats. PLoS ONE, 11. (2). doi: 10.1371/journal.pone.0150102

Erjavec, Igor, et al. "Constitutively elevated blood serotonin is associated with bone loss and type 2 diabetes in rats." PLoS ONE, vol. 11, no. 2, 2016. https://doi.org/10.1371/journal.pone.0150102

Erjavec, Igor, Tatjana Bordukalo Nikšić, Jelena Brkljačić, Danka Grčević, Gordana Mokrović, Maja Kesić, Dunja Rogić, et al. "Constitutively elevated blood serotonin is associated with bone loss and type 2 diabetes in rats." PLoS ONE 11, no. 2 (2016). https://doi.org/10.1371/journal.pone.0150102

Erjavec, I., et al. (2016) 'Constitutively elevated blood serotonin is associated with bone loss and type 2 diabetes in rats', PLoS ONE, 11(2). doi: 10.1371/journal.pone.0150102

Erjavec I, Bordukalo Nikšić T, Brkljačić J, Grčević D, Mokrović G, Kesić M, and sur.. Constitutively elevated blood serotonin is associated with bone loss and type 2 diabetes in rats. PLoS ONE [Internet]. 2016 February 23 [cited 2025 April 10];11(2). doi: 10.1371/journal.pone.0150102

I. Erjavec, et al., "Constitutively elevated blood serotonin is associated with bone loss and type 2 diabetes in rats", PLoS ONE, vol. 11, no. 2, February 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:297045. [Accessed: 10 April 2025]

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Metadata
Title (english)Constitutively elevated blood serotonin is associated with bone loss and type 2 diabetes in rats
AuthorIgor Erjavec
AuthorTatjana Bordukalo-Nikšić
AuthorJelena Brkljačić
AuthorDanka Grčević
AuthorGordana Mokrović
AuthorMaja Kesić
AuthorDunja Rogić
AuthorWilliam Zavadoski
AuthorVishwas M. Paralkar
AuthorLovorka Grgurević
AuthorVladimir Trkulja
AuthorLipa Čičin-Šain
AuthorSlobodan Vukičević
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Reduced peripheral serotonin (5HT) in mice lacking tryptophan hydroxylase (TPH1), the rate limiting enzyme for 5HT synthesis, was reported to be anabolic to the skeleton. However, in other studies TPH1 deletion either had no bone effect or an age dependent inhibition of osteoclastic bone resorption. The role of 5HT in bone therefore remains poorly understood. To address this issue, we used selective breeding to create rat sublines with constitutively high (high-5HT) and low (low-5HT) platelet... More 5HT level (PSL) and platelet 5HT uptake (PSU). High-5HT rats had decreased bone volume due to increased bone turnover characterized by increased bone formation and mineral apposition rate, increased osteoclast number and serum C-telopeptide level. Daily oral administration of the TPH1 inhibitor (LX1032) for 6 weeks reduced PSL and increased the trabecular bone volume and trabecular number of the spine and femur in high-5HT rats. High-5HT animals also developed a type 2 diabetes (T2D) phenotype with increased: plasma insulin, glucose, hemoglobin A1c, body weight, visceral fat, β-cell pancreatic islets size, serum cholesterol, and decreased muscle strength. Serum calcium accretion mediated by parathyroid hormone slightly increased, whereas treatment with 1,25(OH)2D3 decreased PSL. Insulin reduction was paralleled by a drop in PSL in high-5HT rats. In vitro, insulin and 5HT synergistically up-regulated osteoblast differentiation isolated from high-5HT rats, whereas TPH1 inhibition decreased the number of bone marrow-derived osteoclasts. These results suggest that constitutively elevated PSL is associated with bone loss and T2D via a homeostatic interplay between the peripheral 5HT, bone and insulin. Less
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePLoS ONE
Numberingvol. 11, no. 2, e0150102
p-ISSN1932-6203
DOIhttps://doi.org/10.1371/journal.pone.0150102
URN:NBNurn:nbn:hr:105:297045
Publication2016-02-23
Document URLhttp://doi.org/10.1371/journal.pone.0150102
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:56:49
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