prikaz prve stranice dokumenta Survival prediction of high-risk outborn neonates with congenital diaphragmatic hernia from capillary blood gases
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Scientific paper - Original scientific paper
Survival prediction of high-risk outborn neonates with congenital diaphragmatic hernia from capillary blood gases
BMC Pediatrics, 16 (2016); 114. https://doi.org/10.1186/s12887-016-0658-y
Grizelj, Ruža; Bojanić, Katarina; Pritišanac, Ena; Luetić, Tomislav; Vuković, Jurica; Weingarten, Toby N.; Schroeder, Darrell R.; Sprung, Juraj

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Grizelj, R., Bojanić, K., Pritišanac, E., Luetić, T., Vuković, J., Weingarten, T. N. ... Sprung, J. (2016). Survival prediction of high-risk outborn neonates with congenital diaphragmatic hernia from capillary blood gases. BMC Pediatrics, 16., 114. doi: 10.1186/s12887-016-0658-y

Grizelj, Ruža, et al. "Survival prediction of high-risk outborn neonates with congenital diaphragmatic hernia from capillary blood gases." BMC Pediatrics, vol. 16, 2016, p. 114. https://doi.org/10.1186/s12887-016-0658-y

Grizelj, Ruža, Katarina Bojanić, Ena Pritišanac, Tomislav Luetić, Jurica Vuković, Toby N. Weingarten, Darrell R. Schroeder and Juraj Sprung. "Survival prediction of high-risk outborn neonates with congenital diaphragmatic hernia from capillary blood gases." BMC Pediatrics 16 (2016): 114. https://doi.org/10.1186/s12887-016-0658-y

Grizelj, R., et al. (2016) 'Survival prediction of high-risk outborn neonates with congenital diaphragmatic hernia from capillary blood gases', BMC Pediatrics, 16, p. 114. doi: 10.1186/s12887-016-0658-y

Grizelj R, Bojanić K, Pritišanac E, Luetić T, Vuković J, Weingarten TN, and sur.. Survival prediction of high-risk outborn neonates with congenital diaphragmatic hernia from capillary blood gases. BMC Pediatrics [Internet]. 2016 July 29 [cited 2024 December 20];16:114. doi: 10.1186/s12887-016-0658-y

R. Grizelj, et al., "Survival prediction of high-risk outborn neonates with congenital diaphragmatic hernia from capillary blood gases", BMC Pediatrics, vol. 16, p. 114, July 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:709768. [Accessed: 20 December 2024]

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Metadata
Title (english)Survival prediction of high-risk outborn neonates with congenital diaphragmatic hernia from capillary blood gases
AuthorRuža Grizelj
AuthorKatarina Bojanić
AuthorEna Pritišanac
AuthorTomislav Luetić
AuthorJurica Vuković
AuthorToby N. Weingarten
AuthorDarrell R. Schroeder
AuthorJuraj Sprung
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: The extent of lung hypoplasia in neonates with congenital diaphragmatic hernia (CDH) can be assessed from gas exchange. We examined the role of preductal capillary blood gases in prognosticating outcome in patients with CDH. ----- METHODS: We retrospectively reviewed demographic data, disease characteristics, and preductal capillary blood gases on admission and within 24 h following admission for 44 high-risk outborn neonates. All neonates were intubated after delivery due to acute respiratory distress, and were emergently transferred via ground ambulance to our unit between 1/2000 and 12/2014. The main outcome measure was survival to hospital discharge and explanatory variables of interest were preductal capillary blood gases obtained on admission and during the first 24 h following admission. ----- RESULTS: Higher ratio of preductal partial pressure of oxygen to fraction of inspired oxygen (PcO2/FIO2) on admission predicted survival (AUC = 0.69, P = 0.04). However, some neonates substantially improve PcO2/FIO2 following initiation of treatment. Among neonates who survived at least 24 h, the highest preductal PcO2/FIO2 achieved in the initial 24 h was the strongest predictor of survival (AUC = 0.87, P = 0.002). Nonsurvivors had a mean admission preductal PcCO2 higher than survivors (91 ± 31 vs. 70 ± 25 mmHg, P = 0.02), and their PcCO2 remained high during the first 24 h of treatment. ----- CONCLUSION: The inability to achieve adequate gas exchange within 24 h of initiation of intensive care treatment is an ominous sign in high-risk outborn neonates with CDH. We suggest that improvement of oxygenation during the first 24 h, along with other relevant clinical signs, should be used when making decisions regarding treatment options in these critically ill neonates.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBMC Pediatrics
Numberingvol. 16, p. 114
p-ISSN1471-2431
DOIhttps://doi.org/10.1186/s12887-016-0658-y
URN:NBNurn:nbn:hr:105:709768
Publication2016-07-29
Document URLhttps://doi.org/10.1186/s12887-016-0658-y
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:57:08