prikaz prve stranice dokumenta Effects of botulinum toxin type A facial injection on monoamines and their metabolites in sensory, limbic and motor brain regions in rats
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Scientific paper - Original scientific paper
Effects of botulinum toxin type A facial injection on monoamines and their metabolites in sensory, limbic and motor brain regions in rats
Neuroscience Letters, 617 (2016); 213-217. https://doi.org/10.1016/j.neulet.2016.02.020
Ibragić, Saida; Matak, Ivica; Dračić, Aida; Smajlović, Ahmed; Muminović, Mehmed; Proft, Florijan; Sofić, Emin; Lacković, Zdravko; Riederer, Peter

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Ibragić, S., Matak, I., Dračić, A., Smajlović, A., Muminović, M., Proft, F. ... Riederer, P. (2016). Effects of botulinum toxin type A facial injection on monoamines and their metabolites in sensory, limbic and motor brain regions in rats. Neuroscience Letters, 617., 213-217. doi: 10.1016/j.neulet.2016.02.020

Ibragić, Saida, et al. "Effects of botulinum toxin type A facial injection on monoamines and their metabolites in sensory, limbic and motor brain regions in rats." Neuroscience Letters, vol. 617, 2016, pp. 213-217. https://doi.org/10.1016/j.neulet.2016.02.020

Ibragić, Saida, Ivica Matak, Aida Dračić, Ahmed Smajlović, Mehmed Muminović, Florijan Proft, Emin Sofić, Zdravko Lacković and Peter Riederer. "Effects of botulinum toxin type A facial injection on monoamines and their metabolites in sensory, limbic and motor brain regions in rats." Neuroscience Letters 617 (2016): 213-217. https://doi.org/10.1016/j.neulet.2016.02.020

Ibragić, S., et al. (2016) 'Effects of botulinum toxin type A facial injection on monoamines and their metabolites in sensory, limbic and motor brain regions in rats', Neuroscience Letters, 617, pp. 213-217. doi: 10.1016/j.neulet.2016.02.020

Ibragić S, Matak I, Dračić A, Smajlović A, Muminović M, Proft F, and sur.. Effects of botulinum toxin type A facial injection on monoamines and their metabolites in sensory, limbic and motor brain regions in rats. Neuroscience Letters [Internet]. 2016 March 23 [cited 2024 May 02];617:213-217. doi: 10.1016/j.neulet.2016.02.020

S. Ibragić, et al., "Effects of botulinum toxin type A facial injection on monoamines and their metabolites in sensory, limbic and motor brain regions in rats", Neuroscience Letters, vol. 617, pp. 213-217, March 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:820906. [Accessed: 02 May 2024]

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Title (english)Effects of botulinum toxin type A facial injection on monoamines and their metabolites in sensory, limbic and motor brain regions in rats
AuthorSaida Ibragić
AuthorIvica Matak
AuthorAida Dračić
AuthorAhmed Smajlović
AuthorMehmed Muminović
AuthorFlorijan Proft
AuthorEmin Sofić
AuthorZdravko Lacković
AuthorPeter Riederer
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Despite its toxicity, botulinum neurotoxin type A (BTX-A) is a valuable therapeutic agent for several motor, autonomic and pain disorders. Numerous studies have described its peripheral as well as central effects. Using reversed-phase High Performance Liquid Chromatography with Electrochemical Detection (HPLC-ED) and gradient elution, we quantified the concentrations of dopamine (DA), noradrenaline (NA), serotonin (5-HT) and their metabolites in 10 brain regions, ipsilateral and contralateral from the site of unilateral BTX-A administration (5 U/kg) into the rat whisker pad. In regions associated with nociception and pain processing we also examined possible BTX-A effects in combination with formalin-induced inflammatory orofacial pain. The dominant BTX-A effects on the monoamines and their metabolites were insignificant. The only significant increase caused by BTX-A alone was that of NA in striatum and serotonin in hypothalamus. While antinociceptive effects of BTX-A are most probably not related to central monoamine concentrations, the localized increased NA and 5-HT concentrations might play a role in reported BTX-A efficacy for the treatment of depression.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleNeuroscience Letters
Numberingvol. 617, pp. 213-217
p-ISSN0304-3940
DOIhttps://doi.org/10.1016/j.neulet.2016.02.020
URN:NBNurn:nbn:hr:105:820906
Publication2016-03-23
Document URLhttps://doi.org/10.1016/j.neulet.2016.02.020
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:57:17