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Scientific paper - Original scientific paper
The degree of anisocytosis predicts survival in patients with primary myelofibrosis
Acta Haematologica, 136 (2016), 2; 98-100. https://doi.org/10.1159/000445247
Lucijanić, Marko; Pejša, Vlatko; Jakšić, Ozren; Mitrović, Zdravko; Tomasović-Lončarić, Čedna; Štoos-Veić, Tajana; Prka, Željko; Piršić, Mario; Hariš, Višnja; Vasilj, Tamara; Kušec, Rajko

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Lucijanić, M., Pejša, V., Jakšić, O., Mitrović, Z., Tomasović Lončarić, Č., Štoos Veić, T. ... Kušec, R. (2016). The degree of anisocytosis predicts survival in patients with primary myelofibrosis. Acta Haematologica, 136. (2), 98-100. doi: 10.1159/000445247

Lucijanić, Marko, et al. "The degree of anisocytosis predicts survival in patients with primary myelofibrosis." Acta Haematologica, vol. 136, no. 2, 2016, pp. 98-100. https://doi.org/10.1159/000445247

Lucijanić, Marko, Vlatko Pejša, Ozren Jakšić, Zdravko Mitrović, Čedna Tomasović Lončarić, Tajana Štoos Veić, Željko Prka, et al. "The degree of anisocytosis predicts survival in patients with primary myelofibrosis." Acta Haematologica 136, no. 2 (2016): 98-100. https://doi.org/10.1159/000445247

Lucijanić, M., et al. (2016) 'The degree of anisocytosis predicts survival in patients with primary myelofibrosis', Acta Haematologica, 136(2), pp. 98-100. doi: 10.1159/000445247

Lucijanić M, Pejša V, Jakšić O, Mitrović Z, Tomasović Lončarić Č, Štoos Veić T, and sur.. The degree of anisocytosis predicts survival in patients with primary myelofibrosis. Acta Haematologica [Internet]. 2016 [cited 2024 December 20];136(2):98-100. doi: 10.1159/000445247

M. Lucijanić, et al., "The degree of anisocytosis predicts survival in patients with primary myelofibrosis", Acta Haematologica, vol. 136, no. 2, pp. 98-100, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:239210. [Accessed: 20 December 2024]

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Metadata
Title (english)The degree of anisocytosis predicts survival in patients with primary myelofibrosis
AuthorMarko Lucijanić
AuthorVlatko Pejša
AuthorOzren Jakšić
AuthorZdravko Mitrović
AuthorČedna Tomasović-Lončarić
AuthorTajana Štoos-Veić
AuthorŽeljko Prka
AuthorMario Piršić
AuthorVišnja Hariš
AuthorTamara Vasilj
AuthorRajko Kušec
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Introduction: Red cell distribution width (RDW) provides a quantitative measure of anisocytosis and it is associated with the presence of subclinical systemic inflammation and a poor outcome in a variety of diseases when elevated. Anisocytosis is a feature of primary myelofibrosis (PMF) but it’s prognostic role in PMF has not yet been evaluated. ----- Patients and methods: 33 newly-diagnosed patients with PMF were analyzed. Baseline RDW values were obtained in addition to CRP, LDH, complete blood count, iron metabolism parameters and JAK2 V617F mutational status. Patients were staged according to IPSS prognostic scoring system, liver and spleen size were assessed by palpation. ----- Results: Median RDW was 19.0% (15.2%-22.5%). RDW correlated significantly with hemoglobin level (p=0.005), CRP (p=0.031), spleen size (p=0.036) and IPSS score (p=0.003). Patients with more pronounced anisocytosis had an inferior overall survival (OS) – very-high RDW (≥19.0%) vs. high RDW (15.1%-18.9%) subgroup, HR 5.37, p=0.002. RDW remained significantly associated with OS (p=0.002) in a multivariate model including IPSS score, hemoglobin level and CRP. ----- Conclusion: A higher degree of anisocytosis is associated with more advanced disease features and a decreased overall survival. RDW encompasses standard prognostic score and may help in the rapid detection of patients with an unfavorable prognosis.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleActa Haematologica
Numberingvol. 136, no. 2, pp. 98-100
p-ISSN0001-5792
DOIhttps://doi.org/10.1159/000445247
URN:NBNurn:nbn:hr:105:239210
Publication2016
Document URLhttps://doi.org/10.1159/000445247
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 08:57:55