prikaz prve stranice dokumenta Significance of myofibroblast appearance in squamous cell carcinoma of the oral cavity on the occurrence of occult regional metastases, distant metastases, and survival
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Scientific paper - Original scientific paper
Significance of myofibroblast appearance in squamous cell carcinoma of the oral cavity on the occurrence of occult regional metastases, distant metastases, and survival
International Journal of Oral and Maxillofacial Surgery, 44 (2015), 9; 1075-1080. https://doi.org/10.1016/j.ijom.2015.05.009
Lukšić, Ivica; Suton, Petar; Manojlović, Spomenka; Virag, Mišo; Petrovečki, Mladen; Macan, Darko

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Lukšić, I., Suton, P., Manojlović, S., Virag, M., Petrovečki, M. & Macan, D. (2015). Significance of myofibroblast appearance in squamous cell carcinoma of the oral cavity on the occurrence of occult regional metastases, distant metastases, and survival. International Journal of Oral and Maxillofacial Surgery, 44. (9), 1075-1080. doi: 10.1016/j.ijom.2015.05.009

Lukšić, Ivica, et al. "Significance of myofibroblast appearance in squamous cell carcinoma of the oral cavity on the occurrence of occult regional metastases, distant metastases, and survival." International Journal of Oral and Maxillofacial Surgery, vol. 44, no. 9, 2015, pp. 1075-1080. https://doi.org/10.1016/j.ijom.2015.05.009

Lukšić, Ivica, Petar Suton, Spomenka Manojlović, Mišo Virag, Mladen Petrovečki and Darko Macan. "Significance of myofibroblast appearance in squamous cell carcinoma of the oral cavity on the occurrence of occult regional metastases, distant metastases, and survival." International Journal of Oral and Maxillofacial Surgery 44, no. 9 (2015): 1075-1080. https://doi.org/10.1016/j.ijom.2015.05.009

Lukšić, I., et al. (2015) 'Significance of myofibroblast appearance in squamous cell carcinoma of the oral cavity on the occurrence of occult regional metastases, distant metastases, and survival', International Journal of Oral and Maxillofacial Surgery, 44(9), pp. 1075-1080. doi: 10.1016/j.ijom.2015.05.009

Lukšić I, Suton P, Manojlović S, Virag M, Petrovečki M, Macan D. Significance of myofibroblast appearance in squamous cell carcinoma of the oral cavity on the occurrence of occult regional metastases, distant metastases, and survival. International Journal of Oral and Maxillofacial Surgery [Internet]. 2015 September [cited 2024 December 23];44(9):1075-1080. doi: 10.1016/j.ijom.2015.05.009

I. Lukšić, P. Suton, S. Manojlović, M. Virag, M. Petrovečki and D. Macan, "Significance of myofibroblast appearance in squamous cell carcinoma of the oral cavity on the occurrence of occult regional metastases, distant metastases, and survival", International Journal of Oral and Maxillofacial Surgery, vol. 44, no. 9, pp. 1075-1080, September 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:029855. [Accessed: 23 December 2024]

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Title (english)Significance of myofibroblast appearance in squamous cell carcinoma of the oral cavity on the occurrence of occult regional metastases, distant metastases, and survival
AuthorIvica Lukšić
AuthorPetar Suton
AuthorSpomenka Manojlović
AuthorMišo Virag
AuthorMladen Petrovečki
AuthorDarko Macan
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The aim of the present study was to assess the frequency of appearance of stromal myofibroblasts in patients with oral squamous cell carcinoma (OSCC) and to further clarify whether myofibroblasts influence tumour suppression or progression. Surgical resection specimens from 152 patients with cT1-T3N0 OSCC were analysed. The frequency of myofibroblasts within the tumour stroma was assessed immunohistochemically and compared with other clinical and histopathological factors. The immunohistochemical reaction for alpha-smooth muscle actin showed positive cells in the stroma of 84.2% of OSCC (n=128). An increased presence of myofibroblasts in the tumour stroma was significantly correlated with T stage (P=0.019), the presence of occult neck metastasis (P<0.001), regional recurrence (P=0.037), and distant metastasis (P=0.008). There was also an association between the presence of myofibroblasts and patient survival (P=0.009). The presence of myofibroblasts was not associated with local recurrence, tumour cell differentiation, mode of invasion, or bone invasion. The results of this study suggest that myofibroblast proliferation facilitates tumour invasion, the occurrence of occult neck disease, and distant metastasis. The survival rate was poorer in patients with abundant myofibroblasts. Further investigations on tumour-associated stroma at the invasive front are needed in order to establish new diagnostic markers and therapeutic strategies.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleInternational Journal of Oral and Maxillofacial Surgery
Numberingvol. 44, no. 9, pp. 1075-1080
p-ISSN0901-5027
DOIhttps://doi.org/10.1016/j.ijom.2015.05.009
URN:NBNurn:nbn:hr:105:029855
Publication2015-09
Document URLhttps://doi.org/10.1016/j.ijom.2015.05.009
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:03:20