prikaz prve stranice dokumenta Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - a consensus report
  Download
PDF 543.05 KB
Scientific paper - Original scientific paper
Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - a consensus report
BMC Neurology, 17 (2017); 102. https://doi.org/10.1186/s12883-017-0877-3
Wallin, Anders; Kapaki, Elisabeth; Boban, Marina; Engelborghs, Sebastian; Hermann, Dirk Matthias; Huisa, Branko; Jonsson, Michael; Gregorič Kramberger, Milica; Lossi, Laura; Malojčić, Branko; Mehrabian, Shima; Merighi, Adalberto; Mukaetova-Ladinska, Elizabeta Blagoja; Paraskevas, George P.; Popescu, Bogdan Ovidiu; Ravid, Rivka; Traykov, Latchezar; Tsivgoulis, Georgios; Weinstein, Galit; Korczyn, Amos; Bjerke, Maria; Rosenberg, Gary More authors...

Cite this document

Wallin, A., Kapaki, E., Boban, M., Engelborghs, S., Hermann, D. M., Huisa, B. ... Rosenberg, G. (2017). Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - a consensus report. BMC Neurology, 17., 102. doi: 10.1186/s12883-017-0877-3

Wallin, Anders, et al. "Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - a consensus report." BMC Neurology, vol. 17, 2017, p. 102. https://doi.org/10.1186/s12883-017-0877-3

Wallin, Anders, Elisabeth Kapaki, Marina Boban, Sebastian Engelborghs, Dirk Matthias Hermann, Branko Huisa, Michael Jonsson, et al. "Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - a consensus report." BMC Neurology 17 (2017): 102. https://doi.org/10.1186/s12883-017-0877-3

Wallin, A., et al. (2017) 'Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - a consensus report', BMC Neurology, 17, p. 102. doi: 10.1186/s12883-017-0877-3

Wallin A, Kapaki E, Boban M, Engelborghs S, Hermann DM, Huisa B, and sur.. Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - a consensus report. BMC Neurology [Internet]. 2017 May 23 [cited 2024 May 07];17:102. doi: 10.1186/s12883-017-0877-3

A. Wallin, et al., "Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - a consensus report", BMC Neurology, vol. 17, p. 102, May 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:605032. [Accessed: 07 May 2024]

Please login to the repository to save this object to your list.
Metadata
Title (english)Biochemical markers in vascular cognitive impairment associated with subcortical small vessel disease - a consensus report
AuthorAnders Wallin
AuthorElisabeth Kapaki
AuthorMarina Boban
AuthorSebastian Engelborghs
AuthorDirk Matthias Hermann
AuthorBranko Huisa
AuthorMichael Jonsson
AuthorMilica Gregorič Kramberger
AuthorLaura Lossi
AuthorBranko Malojčić
AuthorShima Mehrabian
AuthorAdalberto Merighi
AuthorElizabeta Blagoja Mukaetova-Ladinska
AuthorGeorge P. Paraskevas
AuthorBogdan Ovidiu Popescu
AuthorRivka Ravid
AuthorLatchezar Traykov
AuthorGeorgios Tsivgoulis
AuthorGalit Weinstein
AuthorAmos Korczyn
AuthorMaria Bjerke
AuthorGary Rosenberg
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: Vascular cognitive impairment (VCI) is a heterogeneous entity with multiple aetiologies, all linked to underlying vascular disease. Among these, VCI related to subcortical small vessel disease (SSVD) is emerging as a major homogeneous subtype. Its progressive course raises the need for biomarker identification and/or development for adequate therapeutic interventions to be tested. In order to shed light in the current status on biochemical markers for VCI-SSVD, experts in field reviewed the recent evidence and literature data. ----- METHOD: The group conducted a comprehensive search on Medline, PubMed and Embase databases for studies published until 15.01.2017. The proposal on current status of biochemical markers in VCI-SSVD was reviewed by all co-authors and the draft was repeatedly circulated and discussed before it was finalized. ----- RESULTS: This review identifies a large number of biochemical markers derived from CSF and blood. There is a considerable overlap of VCI-SSVD clinical symptoms with those of Alzheimer's disease (AD). Although most of the published studies are small and their findings remain to be replicated in larger cohorts, several biomarkers have shown promise in separating VCI-SSVD from AD. These promising biomarkers are closely linked to underlying SSVD pathophysiology, namely disruption of blood-CSF and blood-brain barriers (BCB-BBB) and breakdown of white matter myelinated fibres and extracellular matrix, as well as blood and brain inflammation. The leading biomarker candidates are: elevated CSF/blood albumin ratio, which reflects BCB/BBB disruption; altered CSF matrix metalloproteinases, reflecting extracellular matrix breakdown; CSF neurofilment as a marker of axonal damage, and possibly blood inflammatory cytokines and adhesion molecules. The suggested SSVD biomarker deviations contrasts the characteristic CSF profile in AD, i.e. depletion of amyloid beta peptide and increased phosphorylated and total tau. ----- CONCLUSIONS: Combining SSVD and AD biomarkers may provide a powerful tool to identify with greater precision appropriate patients for clinical trials of more homogeneous dementia populations. Thereby, biomarkers might promote therapeutic progress not only in VCI-SSVD, but also in AD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleBMC Neurology
Numberingvol. 17, p. 102
p-ISSN1471-2377
DOIhttps://doi.org/10.1186/s12883-017-0877-3
URN:NBNurn:nbn:hr:105:605032
Publication2017-05-23
Document URLhttps://doi.org/10.1186/s12883-017-0877-3
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 09:12:42