Kisspeptin as a promising oocyte maturation trigger for in vitro fertilisation in humans

Scientific paper - Original scientific paper

• Author: Miro Kasum
• Author: Daniela Franulić
• Author: Ermin Čehić
• Author: Slavko Orešković
• Author: Albert Lila
• Author: Emina Ejubović
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

The aim of this review is to analyse the effectiveness of exogenous kisspeptin administration as a novel alternative of triggering oocyte maturation, instead of currently used triggers such as human chorionic gonadotropin (hCG) or gonadotropin releasing hormone (GnRH) agonist, in women undergoing in vitro fertilisation (IVF) treatment. Kisspeptin has been considered a master regulator of two modes of GnRH and hence gonadotropin secretion, pulses and surges. Administration of kisspeptin-10 and kisspeptin-54 induces the luteinising hormone (LH) surge required for egg maturation and ovulation in animal investigations and LH release during the preovulatory phase of the menstrual cycle and hypothalamic amenorrhoea in humans. Exogenous kisspeptin-54 has been successfully administered as a promising method of triggering oocyte maturation, following ovarian stimulation with gonadotropins and GnRH antagonists in women undergoing IVF, due to its efficacy considering achieved pregnancy rates compared to hCG and GnRH agonists. Also, its safety in patients at high risk of developing ovarian hyperstimulation syndrome is noteworthy. Nevertheless, further studies would be desirable to establish the optimal trigger of egg maturation and to improve the reproductive outcome for women undergoing IVF treatment.

• Keywords (english): Adult; Animals; Female; Fertility Agents, Female/adverse effects; Fertility Agents, Female/metabolism; Fertility Agents, Female/therapeutic use; Fertilization in Vitro/adverse effects; Humans; Infertility, Female/therapy; Kisspeptins/adverse effects; Kisspeptins/genetics; Kisspeptins/metabolism; Kisspeptins/therapeutic use; Oogenesis/drug effects; Ovarian Hyperstimulation Syndrome/chemically induced; Ovarian Hyperstimulation Syndrome/epidemiology; Ovarian Hyperstimulation Syndrome/prevention & control; Ovulation/drug effects; Ovulation Induction/adverse effects; Peptide Fragments/adverse effects; Peptide Fragments/genetics; Peptide Fragments/metabolism; Peptide Fragments/therapeutic use; Pregnancy; Pregnancy Rate; Recombinant Proteins/adverse effects; Recombinant Proteins/metabolism; Recombinant Proteins/therapeutic use; Risk
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Accepted version
• Journal title: Gynecological Endocrinology
• Numbering: vol. 33, no. 8, pp. 583-587
• p-ISSN: 0951-3590
• DOI: https://doi.org/10.1080/09513590.2017.1309019
• URN:NBN: urn:nbn:hr:105:165983
• Publication: 2017-08
• Document URL: https://doi.org/10.1080/09513590.2017.1309019
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 09:18:01