The incidence of hyperechoic prostate cancer in transrectal ultrasound-guided biopsy specimens

Scientific paper - Original scientific paper

• Author: Borislav Spajić
• Author: Hrvoje Čupić
• Author: Davor Tomas
• Author: Goran Štimac
• Author: Božo Krušlin
• Author: Ognjen Kraus
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

OBJECTIVES: To estimate the incidence of transrectal ultrasound (TRUS) hyperechoic lesions and of hyperechoic prostate cancer in TRUS-guided biopsy specimens. ----- METHODS: We prospectively studied 200 patients with total prostate-specific antigen values less than 20 ng/mL and/or positive results on digital rectal examination who had undergone TRUS-guided prostate biopsy. Each patient underwent laterally directed systemic six-core biopsy plus cores from abnormal TRUS lesions and rectally palpable lesions. Six to 10 biopsy cores were obtained from each patient. ----- RESULTS: Hyperechoic lesions were found in 19 patients (9.5%), hypoechoic in 83 (41.5%), and isoechoic in 98 (49.0%). Prostate cancer was diagnosed in 33.0% of study patients. Isoechoic findings on TRUS were recorded in 31.8% of patients diagnosed with prostate cancer, whereas 60.6% of cancers had hypoechoic and 7.6% hyperechoic lesions. There was no significant difference in the mean Gleason score between isoechoic cancers (mean 5.4) and hypoechoic cancers (mean 5.6). However, hyperechoic cancers had a mean Gleason score of 7.0, which was higher when compared with isoechoic and hypoechoic cancers. ----- CONCLUSIONS: Biopsy of hyperechoic lesions was positive for prostate cancer in a higher percentage of patients than previously reported in the literature, and Gleason score of these cancers was higher when compared with isoechoic and hypoechoic cancers.

• Keywords (english): Biopsy, Needle; Ultrasonography, Interventional; Prostatic Neoplasms - diagnosis - pathology - ultrasonography; Aged; Humans; Male; Middle Aged; Prostate - pathology; Prostate-Specific Antigen - blood
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Accepted version
• Journal title: Urology
• Numbering: vol. 70, no. 4, pp. 734-737
• p-ISSN: 0090-4295
• DOI: https://doi.org/10.1016/j.urology.2007.06.1092
• URN:NBN: urn:nbn:hr:105:987747
• Publication: 2007-10
• Document URL: http://doi.org/10.1016/j.urology.2007.06.1092
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 09:25:17