Transfuzijski okidači tijekom operacijskog zahvata

master's thesis

• Title (english): Transfusion triggers during surgery
• Author: Darija Bogdanić
• Mentor: Vesna Vegar-Brozović (mentor)
• Committee member: DINKO TONKOVIĆ (predsjednik povjerenstva)
• Committee member: Daniela Bandić Pavlović (član povjerenstva)
• Committee member: Vesna Vegar-Brozović (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Anaesthesiology, Resuscitation and Intensive Care in Surgical Specialities); Zagreb
• Defense date and country: 2015-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Anesthesiology and Reanimatology

Abstract

Transfuzija krvi (lat. transfundere = preliti) je proces prenošenja krvi ili krvnih produkata iz krvnog sustava jedne osobe u krvni sustav druge osobe. Premda transfuzija kao medicinski postupak postoji od sedamnaestog stoljeća i od tada su prošle mnoge godine, nisu riješeni svi problemi vezani uz transfuziju krvi. Najznačajniji od tih problema su imunološke reakcije i infekcije. Stoga bi transfuzija krvi i krvnih pripravaka u kirurških bolesnika trebala biti optimalna i učinkovita, na način da se primjeni odgovarajući krvni pripravak u odgovarajuće vrijeme i na adekvatan način. Glavni razlozi za transfuziju krvi tijekom operacijskog zahvata su ispravak anemije i poboljšanje tkivne oksigenacije. Pojam transfuzijskog okidača obično se odnosi na laboratorijske vrijednosti hemoglobina ili hematokrita pri kojima je u većine pacijenata potrebna transfuzija koncentriranih eritrocita. Do 1980-ih i 1990-ih godina, smatralo se da je glavni transfuzijski okidač pravilo 100/30. Tijekom posljednjih 15-20 godina to se stajalište promijenilo, tako da se više ne primjenjuje liberalno 100/30 pravilo. Većina stručnjaka se danas slaže da je restriktivna strategija novo pravilo koje bi se trebalo slijediti, a ono kaže da se transfuzija treba uzeti u obzir ako je vrijednost hemoglobina 80 g/L ili manje. Ako hemoglobin padne ispod 70 g/L transfuzija je obično indicirana. Međutim, jednstveni transfuzijski okidač još ne postoji i odluka o transfuziji bi se trebala temeljiti na vrijednostima hemoglobina i hematokrita te također na kliničkom stanju bolesnika.

Abstract (english)

Blood transfusion (lat. transfundere = transfuse, overflow) is the transfer of blood or blood components from one person (the donor) into the bloodstream of another person (the recipient). Even though transfusion as medical procedure exists since seventeenth century and many years have passed, not all the problems regarding transfusion have been solved. The most significant of those problems are immunologic reactions and infections. Therefore, transfusion of blood and blood products in surgical patients should be optimal and efficient, which means using adequate blood components at adequate time and adequate way. The main reasons for blood transfusion during surgery are to correct anemia and to improve tissue oxygenation The term transfusion trigger usually refers to the hemoglobin or hematocrit laboratory level at which most patients need red blood cell transfusion. Until the 1980s and 1990s, it was believed that the main transfusion trigger was 100/30 rule. During last 15 to 20 years that standpoint has changed so that the liberal 100/30 rule is no longer applied. Most experts now agree that restrictive strategy is a new go by rule and it says that transfusion should be considered if hemoglobin is 80 g/L or less. If hemoglobin goes below 70 g/L transfusion is usually indicated. However, single transfusion trigger still does not exist and the decision to transfuse should be based on the hemoglobin and hematocrit laboratory levels and also clinical condition of the patient.

• Keywords: transfuzija; hemoglobin; transfuzijski okidač
• Keywords (english): transfusion; hemoglobin; transfusion trigger
• Language: croatian
• URN:NBN: urn:nbn:hr:105:331031
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-08-11 08:54:13