prikaz prve stranice dokumenta HDL subclasses and mortality in acute heart failure patients
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Scientific paper - Original scientific paper
HDL subclasses and mortality in acute heart failure patients
Clinica Chimica Acta, 490 (2019); 81-87. https://doi.org/10.1016/j.cca.2018.12.020
Degoricija, Vesna; Potočnjak, Ines; Gastrager, Michaela; Pregartner, Gudrun; Berghold, Andrea; Scharnagl, Hubert; Stojaković, Tatjana; Tiran, Beate; Marsche, Gunther; Frank, Saša

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Degoricija, V., Potočnjak, I., Gastrager, M., Pregartner, G., Berghold, A., Scharnagl, H. ... Frank, S. (2019). HDL subclasses and mortality in acute heart failure patients. Clinica Chimica Acta, 490., 81-87. doi: 10.1016/j.cca.2018.12.020

Degoricija, Vesna, et al. "HDL subclasses and mortality in acute heart failure patients." Clinica Chimica Acta, vol. 490, 2019, pp. 81-87. https://doi.org/10.1016/j.cca.2018.12.020

Degoricija, Vesna, Ines Potočnjak, Michaela Gastrager, Gudrun Pregartner, Andrea Berghold, Hubert Scharnagl, Tatjana Stojaković, Beate Tiran, Gunther Marsche and Saša Frank. "HDL subclasses and mortality in acute heart failure patients." Clinica Chimica Acta 490 (2019): 81-87. https://doi.org/10.1016/j.cca.2018.12.020

Degoricija, V., et al. (2019) 'HDL subclasses and mortality in acute heart failure patients', Clinica Chimica Acta, 490, pp. 81-87. doi: 10.1016/j.cca.2018.12.020

Degoricija V, Potočnjak I, Gastrager M, Pregartner G, Berghold A, Scharnagl H, and sur.. HDL subclasses and mortality in acute heart failure patients. Clinica Chimica Acta [Internet]. 2019 March [cited 2024 December 20];490:81-87. doi: 10.1016/j.cca.2018.12.020

V. Degoricija, et al., "HDL subclasses and mortality in acute heart failure patients", Clinica Chimica Acta, vol. 490, pp. 81-87, March 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:930004. [Accessed: 20 December 2024]

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Metadata
Title (english)HDL subclasses and mortality in acute heart failure patients
AuthorVesna Degoricija
AuthorInes Potočnjak
AuthorMichaela Gastrager
AuthorGudrun Pregartner
AuthorAndrea Berghold
AuthorHubert Scharnagl
AuthorTatjana Stojaković
AuthorBeate Tiran
AuthorGunther Marsche
AuthorSaša Frank
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The link between HDL subclasses and the prognosis of cardiovascular diseases remains controversial. We thus evaluated the prognostic value of the HDL subclasses 3 and 2 cholesterol (HDL3-C, HDL2-C) as well as of total HDL-C for 3-month mortality in acute heart failure (AHF) patients. The serum levels of HDL3-C and total HDL-C were determined by detergent-based homogeneous assay. HDL2-C was computed by the difference between total HDL-C and HDL3-C. Out of the 132 analyzed patients, 35 (26.5%) died within three months after onset of AHF. Univariate logistic regression analyses revealed a significant inverse association of HDL3-C (odds ratio (OR) 0.46 per 1-SD increase, 95% confidence interval (CI) 0.27-0.72, p = 0.001) with 3-month mortality, whereas concentrations of total HDL-C and HDL2-C showed no significant association. After adjustment for various laboratory and clinical parameters known to be associated with mortality in heart failure patients, HDL3-C concentrations remained significantly associated with 3-month mortality (OR 0.34 per 1-SD increase, 95% CI 0.15-0.74, p =0.010). We conclude that low admission serum levels of HDL3-C are associated with an increased 3-month mortality in AHF patients, whereas total HDL-C and HDL2-C showed no association. HDL3-C might thus be useful as a prognostic parameter in AHF.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleClinica Chimica Acta
Numberingvol. 490, pp. 81-87
p-ISSN0009-8981
DOIhttps://doi.org/10.1016/j.cca.2018.12.020
URN:NBNurn:nbn:hr:105:930004
Publication2019-03
Document URLhttps://doi.org/10.1016/j.cca.2018.12.020
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:07:03