HDL subclasses and mortality in acute heart failure patients

Scientific paper - Original scientific paper

• Author: Vesna Degoricija
• Author: Ines Potočnjak
• Author: Michaela Gastrager
• Author: Gudrun Pregartner
• Author: Andrea Berghold
• Author: Hubert Scharnagl
• Author: Tatjana Stojaković
• Author: Beate Tiran
• Author: Gunther Marsche
• Author: Saša Frank
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

The link between HDL subclasses and the prognosis of cardiovascular diseases remains controversial. We thus evaluated the prognostic value of the HDL subclasses 3 and 2 cholesterol (HDL3-C, HDL2-C) as well as of total HDL-C for 3-month mortality in acute heart failure (AHF) patients. The serum levels of HDL3-C and total HDL-C were determined by detergent-based homogeneous assay. HDL2-C was computed by the difference between total HDL-C and HDL3-C. Out of the 132 analyzed patients, 35 (26.5%)... More died within three months after onset of AHF. Univariate logistic regression analyses revealed a significant inverse association of HDL3-C (odds ratio (OR) 0.46 per 1-SD increase, 95% confidence interval (CI) 0.27-0.72, p = 0.001) with 3-month mortality, whereas concentrations of total HDL-C and HDL2-C showed no significant association. After adjustment for various laboratory and clinical parameters known to be associated with mortality in heart failure patients, HDL3-C concentrations remained significantly associated with 3-month mortality (OR 0.34 per 1-SD increase, 95% CI 0.15-0.74, p =0.010). We conclude that low admission serum levels of HDL3-C are associated with an increased 3-month mortality in AHF patients, whereas total HDL-C and HDL2-C showed no association. HDL3-C might thus be useful as a prognostic parameter in AHF. Less

• Keywords (english): Acute Disease; Aged; Aged, 80 and over; Cholesterol, HDL/blood; Female; Heart Failure/blood; Heart Failure/mortality; Humans; Male; Middle Aged; Risk Factors
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Clinica Chimica Acta
• Numbering: vol. 490, pp. 81-87
• p-ISSN: 0009-8981
• DOI: https://doi.org/10.1016/j.cca.2018.12.020
• URN:NBN: urn:nbn:hr:105:930004
• Publication: 2019-03
• Document URL: https://doi.org/10.1016/j.cca.2018.12.020
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 10:07:03