Kontrola menstruacijskog ciklusa za medicinski potpomognutu oplodnju

master's thesis

• Title (english): Menstrual cycle control for medically assisted fertilization
• Author: Lanatina Mihaljinec
• Mentor: Branko Radaković (mentor)
• Committee member: Marina Šprem Goldštajn (predsjednik povjerenstva)
• Committee member: Dinka Pavičić-Baldani (član povjerenstva)
• Committee member: Branko Radaković (član povjerenstva)
• Granter: University of Zagreb; School of Medicine; (Department of Gynecology and Obstetrics); Zagreb
• Defense date and country: 2015-07-15, Croatia
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences; Gynecology and Obstetrics

Abstract

Neplodnost kao jedan od vodećih javnozdravstvenih problema se definira kao izostanak trudnoće nakon jedne godine nastojanja u zajedničkom životu. Prvi korak u liječenju bračne neplodnosti je cjelovita anamneza i ginekološki pregled žene. Sljedeći korak je dokazati urednu ovulaciju, prohodnost jajovoda te provjeriti kvalitetu spermiograma partnera. Ovisno o uzroku neplodnosti može se pristupiti različitim metodama liječenja. Metode medicinski pomognute oplodnje (MPO) najčešći su i najvažniji način liječenja neplodnosti. Od metoda MPO najviše se primjenjuje izvantjelesna oplodnja (IVF). Jajne stanice za IVF možemo dobiti u prirodnom ili stimuliranom ciklusu žene. Odabir i protokoli ovise o dobi para, nalazima i prethodnim postupcima. Prirodni ciklus može biti čisti prirodni u kojem nema nikakvih medikamentoznih dodataka i modificirani prirodni ciklus. Stimulirane cikluse dijelimo na blagu stimulaciju i konvencionalnu odnosno standardnu stimulaciju ovulacije. Komplikacije kontrolirane ovarijske hiperstimulacije (KOH) obuhvaćaju sindrom ovarijske hiperstimulacije (OHSS) , povećana učestalost višeplodnih trudnoća, izvanmaterničnih i heterotopičnih trudnoća i učinak na razvoj zloćudnih novotvorina jajnika i dojke, koji do sada nije potvrđen. Zato danas stručne udruge preporučuju blaže protokole stimulacije ovulacije i manje zametaka prenesenih u maternicu. Odabir blažih protokola nosi nešto niži pojedinačni uspjeh od klasičnog IVF-a, ali je zbirni uspjeh tijekom jedne godine liječenja isti

Abstract (english)

Infertility as one of the leading public health problems is defined as absence of pregnacy after one year of trying in a common life. The first step in medical treatment of maternal infertility is an overall anamnesis and gynaecological examination. The next step is to demonstrate proper ovulation, tubal patency and check the quality of partners spermiogram. Depending on the sample od infertility various methods can be applied. Method of medically assisted reproduction is most common and most important way of infertility treatment. The most used method of medically assisted reproduction is in vitro fertilization.Oocytes for IVFcan be obtained in a natural or stimulated cycle of women. Choice and protocols depend on the age of the couple, test results and previous treatments. Natural cycle can be a pure cycle without any medicaments and modified natural cycle. Stimulated cycles are devided into a mild stimulation and conventional, standard stimulation od ovulation. Complications of controled ovarian hyperstimulation include ovarian hyperstimulation syndrome, increases frequency of multiple pregnacies, ectopic and heterotopic pregnancies, and possible development of malign formations of ovary and breasts , wich so far have not been confirmed. That is the reason why professional associations suggest mild protocols of stimulation and less embryos carried into uterus. The chioce of more mild protocols brings lower individual success compared to classical IVF, but the overall success in the courese of one year of treatment is the same.

• Keywords: MPO; Neplodnost
• Keywords (english): medically assisted reproduction; Infertility
• Language: croatian
• URN:NBN: urn:nbn:hr:105:161088
• Study programme: Title: Medicine; Study programme type: university; Study level: integrated undergraduate and graduate; Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
• Type of resource: Text
• File origin: Born digital
• Access conditions: Open access
• Created on: 2016-08-11 09:32:03