prikaz prve stranice dokumenta A score derived from routine biochemical parameters increases the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine neoplasms
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Scientific paper - Original scientific paper
A score derived from routine biochemical parameters increases the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine neoplasms
Endocrine, 60 (2018), 3; 395-406. https://doi.org/10.1007/s12020-018-1592-6
Kruljac, Ivan; Vurnek, Ivan; Maasberg, Sebastian; Kust, Davor; Blaslov, Kristina; Ladika Davidović, Blaženka; Štefanović, Mario; Demirović, Alma; Bišćanin, Alen; Filipović-Čugura, Jakša; Marić Brozić, Jasmina; Pape, Ulrich-Frank; Vrkljan, Milan

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Kruljac, I., Vurnek, I., Maasberg, S., Kust, D., Blaslov, K., Ladika Davidović, B. ... Vrkljan, M. (2018). A score derived from routine biochemical parameters increases the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine neoplasms. Endocrine, 60. (3), 395-406. doi: 10.1007/s12020-018-1592-6

Kruljac, Ivan, et al. "A score derived from routine biochemical parameters increases the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine neoplasms." Endocrine, vol. 60, no. 3, 2018, pp. 395-406. https://doi.org/10.1007/s12020-018-1592-6

Kruljac, Ivan, Ivan Vurnek, Sebastian Maasberg, Davor Kust, Kristina Blaslov, Blaženka Ladika Davidović, Mario Štefanović, et al. "A score derived from routine biochemical parameters increases the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine neoplasms." Endocrine 60, no. 3 (2018): 395-406. https://doi.org/10.1007/s12020-018-1592-6

Kruljac, I., et al. (2018) 'A score derived from routine biochemical parameters increases the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine neoplasms', Endocrine, 60(3), pp. 395-406. doi: 10.1007/s12020-018-1592-6

Kruljac I, Vurnek I, Maasberg S, Kust D, Blaslov K, Ladika Davidović B, and sur.. A score derived from routine biochemical parameters increases the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine neoplasms. Endocrine [Internet]. 2018 June [cited 2024 May 02];60(3):395-406. doi: 10.1007/s12020-018-1592-6

I. Kruljac, et al., "A score derived from routine biochemical parameters increases the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine neoplasms", Endocrine, vol. 60, no. 3, pp. 395-406, June 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:826938. [Accessed: 02 May 2024]

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Metadata
Title (english)A score derived from routine biochemical parameters increases the diagnostic accuracy of chromogranin A in detecting patients with neuroendocrine neoplasms
AuthorIvan Kruljac
AuthorIvan Vurnek
AuthorSebastian Maasberg
AuthorDavor Kust
AuthorKristina Blaslov
AuthorBlaženka Ladika Davidović
AuthorMario Štefanović
AuthorAlma Demirović
AuthorAlen Bišćanin
AuthorJakša Filipović-Čugura
AuthorJasmina Marić Brozić
AuthorUlrich-Frank Pape
AuthorMilan Vrkljan
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
BACKGROUND: Chromogranin A (CgA) is a valuable biomarker for detection and follow-up of patients with neuroendocrine neoplasms (NENs). However, various comorbidities may influence serum CgA, which decreases its diagnostic accuracy. We aimed to investigate which laboratory parameters are independently associated with increased CgA in real-life setting and to develop a scoring system, which could improve the diagnostic accuracy of CgA in detecting patients with NENs. ----- METHODS: This retrospective study included 55 treatment naïve patients with NENs and160 patients with various comorbidities but without NEN (nonNENs). Scoring system (CgA-score) was developed based on z-scores obtained from receiver operating curve analysis for each parameter that was associated with elevated serum CgA in nonNENs. ----- RESULTS: CgA correlated positively with serum BUN, creatinine, α2-globulin, red-cell distribution width, erythrocyte sedimentation rate, plasma glucose and correlated inversely with hemoglobin, thrombocytes and serum albumin. Serum CgA was also associated with the presence of chronic renal failure, arterial hypertension and diabetes and the use of PPI. In the entire study population, CgA showed an area under the curve of 0.656. Aforementioned parameters were used to develop a CgA-score. In a cohort of patients with CgA-score <12.0 (N = 87), serum CgA >156.5 ng/ml had 77.8% sensitivity and 91.5% specificity for detecting NENs (AUC 0.841, 95% CI 0.713-0.969, P < 0.001). Serum CgA had no diagnostic value in detecting NENs in patients with CgA-score >12.0 (AUC 0.554, 95% CI 0.405-0.702, P = 0.430). ----- CONCLUSIONS: CgA-score encompasses a wide range of comorbidities and represents a promising tool that could improve diagnostic performance of CgA in everyday clinical practice.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleEndocrine
Numberingvol. 60, no. 3, pp. 395-406
p-ISSN1355-008X
DOIhttps://doi.org/10.1007/s12020-018-1592-6
URN:NBNurn:nbn:hr:105:826938
Publication2018-06
Document URLhttp://doi.org/10.1007/s12020-018-1592-6
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:14:08