prikaz prve stranice dokumenta Follicular fluid vascular endothelial growth factor is associated with type of infertility and interferon alpha correlates with endometrial thickness in natural cycle in vitro fertilization
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Scientific paper - Original scientific paper
Follicular fluid vascular endothelial growth factor is associated with type of infertility and interferon alpha correlates with endometrial thickness in natural cycle in vitro fertilization
Reproductive Biology, 18 (2018), 3; 289-294. https://doi.org/10.1016/j.repbio.2018.06.001
Hafner, Daria; Vujišić Živković, Sanja; Bauman, Renato; Kujundžić Tiljak, Mirjana; Papić, Neven; Židovec Lepej, Snježana

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Hafner, D., Vujišić Živković, S., Bauman, R., Kujundžić Tiljak, M., Papić, N. & Židovec Lepej, S. (2018). Follicular fluid vascular endothelial growth factor is associated with type of infertility and interferon alpha correlates with endometrial thickness in natural cycle in vitro fertilization. Reproductive Biology, 18. (3), 289-294. doi: 10.1016/j.repbio.2018.06.001

Hafner, Daria, et al. "Follicular fluid vascular endothelial growth factor is associated with type of infertility and interferon alpha correlates with endometrial thickness in natural cycle in vitro fertilization." Reproductive Biology, vol. 18, no. 3, 2018, pp. 289-294. https://doi.org/10.1016/j.repbio.2018.06.001

Hafner, Daria, Sanja Vujišić Živković, Renato Bauman, Mirjana Kujundžić Tiljak, Neven Papić and Snježana Židovec Lepej. "Follicular fluid vascular endothelial growth factor is associated with type of infertility and interferon alpha correlates with endometrial thickness in natural cycle in vitro fertilization." Reproductive Biology 18, no. 3 (2018): 289-294. https://doi.org/10.1016/j.repbio.2018.06.001

Hafner, D., et al. (2018) 'Follicular fluid vascular endothelial growth factor is associated with type of infertility and interferon alpha correlates with endometrial thickness in natural cycle in vitro fertilization', Reproductive Biology, 18(3), pp. 289-294. doi: 10.1016/j.repbio.2018.06.001

Hafner D, Vujišić Živković S, Bauman R, Kujundžić Tiljak M, Papić N, Židovec Lepej S. Follicular fluid vascular endothelial growth factor is associated with type of infertility and interferon alpha correlates with endometrial thickness in natural cycle in vitro fertilization. Reproductive Biology [Internet]. 2018 [cited 2024 April 11];18(3):289-294. doi: 10.1016/j.repbio.2018.06.001

D. Hafner, S. Vujišić Živković, R. Bauman, M. Kujundžić Tiljak, N. Papić and S. Židovec Lepej, "Follicular fluid vascular endothelial growth factor is associated with type of infertility and interferon alpha correlates with endometrial thickness in natural cycle in vitro fertilization", Reproductive Biology, vol. 18, no. 3, pp. 289-294, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:935747. [Accessed: 11 April 2024]

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Title (english)Follicular fluid vascular endothelial growth factor is associated with type of infertility and interferon alpha correlates with endometrial thickness in natural cycle in vitro fertilization
AuthorDaria Hafner
AuthorSanja Vujišić Živković
AuthorRenato Bauman
AuthorMirjana Kujundžić Tiljak
AuthorNeven Papić
AuthorSnježana Židovec Lepej
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
The aim of this study was to analyse the presence of vascular endothelial growth factor (VEGF) and interferon alpha (IFN-α) in the follicular fluid (FF) and their possible influence, as pro-angiogenic or anti-angiogenic factors, on in vitro fertilization outcome. The concentrations of VEGF and IFN-α were correlated with oocyte and embryo quality, concentrations of hormones in the serum, perifollicular blood flow and endometrial thickness. VEGF was detected in all FF samples (median 706.6 pg/ml, range 182.9-6638 pg/ml). IFN-α was detected in 60% of the samples (median 6.5 pg/ml, range 0-79.4 pg/ml), while in 40% of the samples its levels were below the test detection limit. VEGF and IFN-α concentrations did not correlate with the cause of infertility, concentrations of FSH, LH, E2 and prolactin, oocyte or embryo quality. Significantly higher concentrations of VEGF have been found in women with primary compared with secondary infertility (p = 0.011, Mann Whitney test). The concentrations of VEGF and IFN-α did not correlate with the resistance index (RI) on days of hCG administration, follicular aspiration and embryo transfer. However, the concentrations of IFN-α correlated with endometrial thickness on the day of embryo transfer (Spearman correlation coefficient ρ = 0.4107; P < 0.05) but not on days of hCG administration and follicular aspiration. The mechanism of VEGF association with the previous ability of having a child needs to be clarified in future studies. The results of this study indicate a possible role of IFN-α in pathways of endometrial remodelling.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleReproductive Biology
Numberingvol. 18, no. 3, pp. 289-294
p-ISSN1642-431X
DOIhttps://doi.org/10.1016/j.repbio.2018.06.001
URN:NBNurn:nbn:hr:105:935747
Publication2018
Document URLhttps://doi.org/10.1016/j.repbio.2018.06.001
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:20:04