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Scientific paper - Original scientific paper
The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer’s disease
Progress in Neurobiology, 168 (2018); 104-127. https://doi.org/10.1016/j.pneurobio.2018.05.001
Jazvinšćak Jembrek, Maja; Slade, Neda; Hof, Patrick R.; Šimić, Goran

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Jazvinšćak Jembrek, M., Slade, N., Hof, P. R. & Šimić, G. (2018). The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer’s disease. Progress in Neurobiology, 168., 104-127. doi: 10.1016/j.pneurobio.2018.05.001

Jazvinšćak Jembrek, Maja, et al. "The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer’s disease." Progress in Neurobiology, vol. 168, 2018, pp. 104-127. https://doi.org/10.1016/j.pneurobio.2018.05.001

Jazvinšćak Jembrek, Maja, Neda Slade, Patrick R. Hof and Goran Šimić. "The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer’s disease." Progress in Neurobiology 168 (2018): 104-127. https://doi.org/10.1016/j.pneurobio.2018.05.001

Jazvinšćak Jembrek, M., et al. (2018) 'The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer’s disease', Progress in Neurobiology, 168, pp. 104-127. doi: 10.1016/j.pneurobio.2018.05.001

Jazvinšćak Jembrek M, Slade N, Hof PR, Šimić G. The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer’s disease. Progress in Neurobiology [Internet]. 2018 September [cited 2024 September 09];168:104-127. doi: 10.1016/j.pneurobio.2018.05.001

M. Jazvinšćak Jembrek, N. Slade, P. R. Hof and G. Šimić, "The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer’s disease", Progress in Neurobiology, vol. 168, pp. 104-127, September 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:226379. [Accessed: 09 September 2024]

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Title (english)The interactions of p53 with tau and Aß as potential therapeutic targets for Alzheimer’s disease
AuthorMaja Jazvinšćak Jembrek
AuthorNeda Slade
AuthorPatrick R. Hof
AuthorGoran Šimić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Alzheimer's disease (AD), the most common progressive neurodegenerative disorder, is characterized by severe cognitive decline and personality changes as a result of synaptic and neuronal loss. The defining clinicopathological hallmarks of the disease are deposits of amyloid precursor protein (APP)-derived amyloid-β peptides (Aβ) in the brain parenchyma, and intracellular aggregates of truncated and hyperphosphorylated tau protein in neurofibrillary tangles (NFT). At the cellular and molecular levels, many intertwined pathological mechanisms that relate Aβ and tau pathology with a transcription factor p53 have been revealed. p53 is activated in response to various stressors that threaten genomic stability. Depending on damage severity, it promotes neuronal death or survival, predominantly via transcription-dependent mechanisms that affect expression of apoptosis-related target genes. Levels of p53 are enhanced in the AD brain and maintain sustained tau hyperphosphorylation, whereas intracellular Aβ directly contributes to p53 pool and promotes downstream p53 effects. The review summarizes the role of p53 in neuronal function, discusses the interactions of p53, tau, and Aβ in the normal brain and during the progression of AD pathology, and considers the impact of the most prominent hereditary risk factors of AD on p53/tau/Aβ interactions. A better understanding of this intricate interplay would provide deeper insight into AD pathology and might offer some novel therapeutic targets for the improvement of treatment options. In this regard, drugs and natural compounds targeting the p53 pathway are of growing interest in neuroprotection as they may represent promising therapeutic approaches in the prevention of oxidative stress-dependent pathological processes underlying AD.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titleProgress in Neurobiology
Numberingvol. 168, pp. 104-127
p-ISSN0301-0082
DOIhttps://doi.org/10.1016/j.pneurobio.2018.05.001
URN:NBNurn:nbn:hr:105:226379
Publication2018-09
Document URLhttp://doi.org/10.1016/j.pneurobio.2018.05.001
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:20:13