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Scientific paper - Original scientific paper
Genome-wide miRNA profiling reinforces the importance of miR-9 in human papillomavirus associated oral and oropharyngeal head and neck cancer
Scientific Reports, 9 (2019), 1; https://doi.org/10.1038/s41598-019-38797-z
Božinović, Ksenija; Sabol, Ivan; Dediol, Emil; Milutin Gašperov, Nina; Manojlović, Spomenka; Vojtechova, Zuzana; Tachezy, Ruth; Grce, Magdalena

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Božinović, K., Sabol, I., Dediol, E., Milutin Gašperov, N., Manojlović, S., Vojtechova, Z. ... Grce, M. (2019). Genome-wide miRNA profiling reinforces the importance of miR-9 in human papillomavirus associated oral and oropharyngeal head and neck cancer. Scientific Reports, 9. (1). doi: 10.1038/s41598-019-38797-z

Božinović, Ksenija, et al. "Genome-wide miRNA profiling reinforces the importance of miR-9 in human papillomavirus associated oral and oropharyngeal head and neck cancer." Scientific Reports, vol. 9, no. 1, 2019. https://doi.org/10.1038/s41598-019-38797-z

Božinović, Ksenija, Ivan Sabol, Emil Dediol, Nina Milutin Gašperov, Spomenka Manojlović, Zuzana Vojtechova, Ruth Tachezy and Magdalena Grce. "Genome-wide miRNA profiling reinforces the importance of miR-9 in human papillomavirus associated oral and oropharyngeal head and neck cancer." Scientific Reports 9, no. 1 (2019). https://doi.org/10.1038/s41598-019-38797-z

Božinović, K., et al. (2019) 'Genome-wide miRNA profiling reinforces the importance of miR-9 in human papillomavirus associated oral and oropharyngeal head and neck cancer', Scientific Reports, 9(1). doi: 10.1038/s41598-019-38797-z

Božinović K, Sabol I, Dediol E, Milutin Gašperov N, Manojlović S, Vojtechova Z, and sur.. Genome-wide miRNA profiling reinforces the importance of miR-9 in human papillomavirus associated oral and oropharyngeal head and neck cancer. Scientific Reports [Internet]. 2019 February 19 [cited 2024 May 01];9(1). doi: 10.1038/s41598-019-38797-z

K. Božinović, et al., "Genome-wide miRNA profiling reinforces the importance of miR-9 in human papillomavirus associated oral and oropharyngeal head and neck cancer", Scientific Reports, vol. 9, no. 1, February 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:805612. [Accessed: 01 May 2024]

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Metadata
Title (english)Genome-wide miRNA profiling reinforces the importance of miR-9 in human papillomavirus associated oral and oropharyngeal head and neck cancer
AuthorKsenija Božinović
AuthorIvan Sabol
AuthorEmil Dediol
AuthorNina Milutin Gašperov
AuthorSpomenka Manojlović
AuthorZuzana Vojtechova
AuthorRuth Tachezy
AuthorMagdalena Grce
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Head and neck cancer is the sixth most common malignancy worldwide, predominantly developing from squamous cell epithelia (HNSCC). The main HNSCC risk factors are tobacco, excessive alcohol use, and the presence of human papillomavirus (HPV). HPV positive (+) cancers are etiologically different from other HNSCC and often show better prognosis. The current knowledge regarding HNSCC miRNA profiles is still incomplete especially in the context of HPV+ cancer. Thus, we analyzed 61 freshly collected primary oral (OSCC) and oropharyngeal (OPSCC) SCC samples. HPV DNA and RNA was found in 21% cases. The Illumina whole-genome small-RNA profiling by next-generation sequencing was done on 22 samples and revealed 7 specific miRNAs to HPV+ OSCC, 77 to HPV+ OPSCC, and additional 3 shared with both; 51 miRNAs were specific to HPV− OPSCC, 62 to HPV− OSCC, and 31 shared with both. The results for 9 miRNAs (miR-9, -21, -29a, -100, -106b, -143 and -145) were assessed by reverse transcription-quantitative polymerase chain reaction on the whole study population. The data was additionally confirmed by reanalyzing publicly available miRNA sequencing Cancer Genome Atlas consortium (TCGA) HNSCC data. Cell signaling pathway analysis revealed differences between HPV+ and HPV− HNSCC. Our findings compared with literature data revealed extensive heterogeneity of miRNA deregulation with only several miRNAs consistently affected, and miR-9 being the most likely HPV related miRNA.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleScientific Reports
Numberingvol. 9, no. 1
p-ISSN2045-2322
DOIhttps://doi.org/10.1038/s41598-019-38797-z
URN:NBNurn:nbn:hr:105:805612
Publication2019-02-19
Document URLhttp://doi.org/10.1038/s41598-019-38797-z
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:27:54