prikaz prve stranice dokumenta Regulation of survivin isoform expression by GLI proteins in ovarian cancer
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Scientific paper - Original scientific paper
Regulation of survivin isoform expression by GLI proteins in ovarian cancer
Cells, 8 (2019), 2; 128. https://doi.org/10.3390/cells8020128
Trnski, Diana; Gregorić, Maja; Levanat, Sonja; Ozretić, Petar; Rinčić, Nikolina; Vidaković, Tajana; Kalafatić, Držislav; Maurac, Ivana; Orešković, Slavko; Sabol, Maja; Musani, Vesna

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Trnski, D., Gregorić, M., Levanat, S., Ozretić, P., Rinčić, N., Vidaković, T. ... Musani, V. (2019). Regulation of survivin isoform expression by GLI proteins in ovarian cancer. Cells, 8. (2), 128. doi: 10.3390/cells8020128

Trnski, Diana, et al. "Regulation of survivin isoform expression by GLI proteins in ovarian cancer." Cells, vol. 8, no. 2, 2019, p. 128. https://doi.org/10.3390/cells8020128

Trnski, Diana, Maja Gregorić, Sonja Levanat, Petar Ozretić, Nikolina Rinčić, Tajana Vidaković, Držislav Kalafatić, et al. "Regulation of survivin isoform expression by GLI proteins in ovarian cancer." Cells 8, no. 2 (2019): 128. https://doi.org/10.3390/cells8020128

Trnski, D., et al. (2019) 'Regulation of survivin isoform expression by GLI proteins in ovarian cancer', Cells, 8(2), p. 128. doi: 10.3390/cells8020128

Trnski D, Gregorić M, Levanat S, Ozretić P, Rinčić N, Vidaković T, and sur.. Regulation of survivin isoform expression by GLI proteins in ovarian cancer. Cells [Internet]. 2019 February 06 [cited 2024 April 24];8(2):128. doi: 10.3390/cells8020128

D. Trnski, et al., "Regulation of survivin isoform expression by GLI proteins in ovarian cancer", Cells, vol. 8, no. 2, p. 128, February 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:649012. [Accessed: 24 April 2024]

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Metadata
Title (english)Regulation of survivin isoform expression by GLI proteins in ovarian cancer
AuthorDiana Trnski
AuthorMaja Gregorić
AuthorSonja Levanat
AuthorPetar Ozretić
AuthorNikolina Rinčić
AuthorTajana Vidaković
AuthorDržislav Kalafatić
AuthorIvana Maurac
AuthorSlavko Orešković
AuthorMaja Sabol
AuthorVesna Musani
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Ovarian cancer (OC) is the most lethal female gynecological malignancy, mostly due to diagnosis in late stages when treatment options are limited. Hedgehog-GLI (HH-GLI) signaling is a major developmental pathway involved in organogenesis and stem cell maintenance, and is activated in OC. One of its targets is survivin (BIRC5), an inhibitor of apoptosis protein (IAP) that plays a role in multiple processes, including proliferation and cell survival. We wanted to investigate the role of different GLI proteins in the regulation of survivin isoform expression (WT, 2α, 2B, 3B, and Dex3) in the SKOV-3 OC cell line. We demonstrated that survivin isoforms are downregulated in GLI1 and GLI2 knock-out cell lines, but not in the GLI3 knock-out. Treatment of GLI1 knock-out cells with GANT-61 shows an additional inhibitory effect on several isoforms. Additionally, we examined the expression of survivin isoforms in OC samples and the potential role of BIRC5 polymorphisms in isoform expression. Clinical samples showed the same pattern of survivin isoform expression as in the cell line, and several BIRC5 polymorphisms showed the correlation with isoform expression. Our results showed that survivin isoforms are regulated both by different GLI proteins and BIRC5 polymorphisms in OC.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCells
Numberingvol. 8, no. 2, p. 128
p-ISSN2073-4409
DOIhttps://doi.org/10.3390/cells8020128
URN:NBNurn:nbn:hr:105:649012
Publication2019-02-06
Document URLhttp://doi.org/10.3390/cells8020128
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:28:05