Association analyses identify 31 new risk loci for colorectal cancer susceptibility

Law, Philip J.; Timofeeva, Maria; Fernandez-Rozadilla, Ceres; Broderick, Peter; Studd, James; Fernandez-Tajes, Juan; Farrington, Susan; Svinti, Victoria; Palles, Claire; Orlando, Giulia; Sud, Amit; Holroyd, Amy; Penegar, Steven; Theodoratou, Evropi; Vaughan-Shaw, Peter; Campbell, Harry; Zgaga, Lina; Hayward, Caroline; Campbell, Archie; Harris, Sarah; Deary, Ian J.; Starr, John; Gatcombe, Laura; Pinna, Maria; Briggs, Sarah; Martin, Lynn; Jaeger, Emma; Sharma-Oates, Archana; East, James; Leedham, Simon; Arnold, Roland; Johnstone, Elaine; Wang, Haitao; Kerr, David; Kerr, Rachel; Maughan, Tim; Kaplan, Richard; Al-Tassan, Nada; Palin, Kimmo; Hänninen, Ulrika A.; Cajuso, Tatiana; Tanskanen, Tomas; Kondelin, Johanna; Kaasinen, Eevi; Sarin, Antti-Pekka; Eriksson, Johan G.; Rissanen, Harri; Knekt, Paul; Pukkala, Eero; Jousilahti, Pekka; Salomaa, Veikko; Ripatti, Samuli; Palotie, Aarno; Renkonen-Sinisalo, Laura; Lepistö, Anna; Böhm, Jan; Mecklin, Jukka-Pekka; Buchanan, Daniel D.; Win, Aung-Ko; Hopper, John; Jenkins, Mark E.; Lindor, Noralane M.; Newcomb, Polly A.; Gallinger, Steven; Duggan, David; Casey, Graham; Hoffmann, Per; Nöthen, Markus M.; Jöckel, Karl-Heinz; Easton, Douglas F.; Pharoah, Paul D. P.; Peto, Julian; Canzian, Federico; Swerdlow, Anthony; Eeles, Rosalind A.; Kote-Jarai, Zsofia; Muir, Kenneth; Pashayan, Nora; Harkin, Andrea; Allan, Karen; McQueen, John; Paul, James; Iveson, Timothy; Saunders, Mark; Butterbach, Katja; Chang-Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann; Kirac, Iva; Matošević, Petar; Hofer, Philipp; Brezina, Stefanie; Gsur, Andrea; Cheadle, Jeremy P.; Aaltonen, Lauri A.; Tomlinson, Ian; Houlston, Richard S.; Dunlop, Malcolm G.

doi:10.1038/s41467-019-09775-w

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Scientific paper - Original scientific paper

Association analyses identify 31 new risk loci for colorectal cancer susceptibility

Nature Communications, 10 (2019), 1; https://doi.org/10.1038/s41467-019-09775-w

Law, Philip J.; Timofeeva, Maria; Fernandez-Rozadilla, Ceres; Broderick, Peter; Studd, James; Fernandez-Tajes, Juan; Farrington, Susan; Svinti, Victoria; Palles, Claire; Orlando, Giulia; Sud, Amit; Holroyd, Amy; Penegar, Steven; Theodoratou, Evropi; Vaughan-Shaw, Peter; Campbell, Harry; Zgaga, Lina; Hayward, Caroline; Campbell, Archie; Harris, Sarah; Deary, Ian J.; Starr, John; Gatcombe, Laura; Pinna, Maria; Briggs, Sarah; Martin, Lynn; Jaeger, Emma; Sharma-Oates, Archana; East, James; Leedham, Simon; Arnold, Roland; Johnstone, Elaine; Wang, Haitao; Kerr, David; Kerr, Rachel; Maughan, Tim; Kaplan, Richard; Al-Tassan, Nada; Palin, Kimmo; Hänninen, Ulrika A.; Cajuso, Tatiana; Tanskanen, Tomas; Kondelin, Johanna; Kaasinen, Eevi; Sarin, Antti-Pekka; Eriksson, Johan G.; Rissanen, Harri; Knekt, Paul; Pukkala, Eero; Jousilahti, Pekka; Salomaa, Veikko; Ripatti, Samuli; Palotie, Aarno; Renkonen-Sinisalo, Laura; Lepistö, Anna; Böhm, Jan; Mecklin, Jukka-Pekka; Buchanan, Daniel D.; Win, Aung-Ko; Hopper, John; Jenkins, Mark E.; Lindor, Noralane M.; Newcomb, Polly A.; Gallinger, Steven; Duggan, David; Casey, Graham; Hoffmann, Per; Nöthen, Markus M.; Jöckel, Karl-Heinz; Easton, Douglas F.; Pharoah, Paul D. P.; Peto, Julian; Canzian, Federico; Swerdlow, Anthony; Eeles, Rosalind A.; Kote-Jarai, Zsofia; Muir, Kenneth; Pashayan, Nora; Harkin, Andrea; Allan, Karen; McQueen, John; Paul, James; Iveson, Timothy; Saunders, Mark; Butterbach, Katja; Chang-Claude, Jenny; Hoffmeister, Michael; Brenner, Hermann; Kirac, Iva; Matošević, Petar; Hofer, Philipp; Brezina, Stefanie; Gsur, Andrea; Cheadle, Jeremy P.; Aaltonen, Lauri A.; Tomlinson, Ian; Houlston, Richard S.; Dunlop, Malcolm G. More authors...

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APA 6th Edition

Law, P. J., Timofeeva, M., Fernandez Rozadilla, C., Broderick, P., Studd, J., Fernandez Tajes, J. ... Dunlop, M. G. (2019). Association analyses identify 31 new risk loci for colorectal cancer susceptibility. Nature Communications, 10. (1). doi: 10.1038/s41467-019-09775-w

MLA 8th Edition

Law, Philip J., et al. "Association analyses identify 31 new risk loci for colorectal cancer susceptibility." Nature Communications, vol. 10, no. 1, 2019. https://doi.org/10.1038/s41467-019-09775-w

Chicago 17th Edition

Law, Philip J., Maria Timofeeva, Ceres Fernandez Rozadilla, Peter Broderick, James Studd, Juan Fernandez Tajes, Susan Farrington, et al. "Association analyses identify 31 new risk loci for colorectal cancer susceptibility." Nature Communications 10, no. 1 (2019). https://doi.org/10.1038/s41467-019-09775-w

Harvard

Law, P. J., et al. (2019) 'Association analyses identify 31 new risk loci for colorectal cancer susceptibility', Nature Communications, 10(1). doi: 10.1038/s41467-019-09775-w

Vancouver

Law PJ, Timofeeva M, Fernandez Rozadilla C, Broderick P, Studd J, Fernandez Tajes J, and sur.. Association analyses identify 31 new risk loci for colorectal cancer susceptibility. Nature Communications [Internet]. 2019 May 14 [cited 2024 November 11];10(1). doi: 10.1038/s41467-019-09775-w

IEEE

P. J. Law, et al., "Association analyses identify 31 new risk loci for colorectal cancer susceptibility", Nature Communications, vol. 10, no. 1, May 2019. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:887802. [Accessed: 11 November 2024]

Cite this item: https://urn.nsk.hr/urn:nbn:hr:105:887802

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Metadata

Title (english)	Association analyses identify 31 new risk loci for colorectal cancer susceptibility
Author	Philip J. Law
Author	Maria Timofeeva
Author	Ceres Fernandez-Rozadilla
Author	Peter Broderick
Author	James Studd
Author	Juan Fernandez-Tajes
Author	Susan Farrington
Author	Victoria Svinti
Author	Claire Palles
Author	Giulia Orlando
Author	Amit Sud
Author	Amy Holroyd
Author	Steven Penegar
Author	Evropi Theodoratou
Author	Peter Vaughan-Shaw
Author	Harry Campbell
Author	Lina Zgaga
Author	Caroline Hayward
Author	Archie Campbell
Author	Sarah Harris
Author	Ian J. Deary
Author	John Starr
Author	Laura Gatcombe
Author	Maria Pinna
Author	Sarah Briggs
Author	Lynn Martin
Author	Emma Jaeger
Author	Archana Sharma-Oates
Author	James East
Author	Simon Leedham
Author	Roland Arnold
Author	Elaine Johnstone
Author	Haitao Wang
Author	David Kerr
Author	Rachel Kerr
Author	Tim Maughan
Author	Richard Kaplan
Author	Nada Al-Tassan
Author	Kimmo Palin
Author	Ulrika A. Hänninen
Author	Tatiana Cajuso
Author	Tomas Tanskanen
Author	Johanna Kondelin
Author	Eevi Kaasinen
Author	Antti-Pekka Sarin
Author	Johan G. Eriksson
Author	Harri Rissanen
Author	Paul Knekt
Author	Eero Pukkala
Author	Pekka Jousilahti
Author	Veikko Salomaa
Author	Samuli Ripatti
Author	Aarno Palotie
Author	Laura Renkonen-Sinisalo
Author	Anna Lepistö
Author	Jan Böhm
Author	Jukka-Pekka Mecklin
Author	Daniel D. Buchanan
Author	Aung-Ko Win
Author	John Hopper
Author	Mark E. Jenkins
Author	Noralane M. Lindor
Author	Polly A. Newcomb
Author	Steven Gallinger
Author	David Duggan
Author	Graham Casey
Author	Per Hoffmann
Author	Markus M. Nöthen
Author	Karl-Heinz Jöckel
Author	Douglas F. Easton
Author	Paul D. P. Pharoah
Author	Julian Peto
Author	Federico Canzian
Author	Anthony Swerdlow
Author	Rosalind A. Eeles
Author	Zsofia Kote-Jarai
Author	Kenneth Muir
Author	Nora Pashayan
Author	Andrea Harkin
Author	Karen Allan
Author	John McQueen
Author	James Paul
Author	Timothy Iveson
Author	Mark Saunders
Author	Katja Butterbach
Author	Jenny Chang-Claude
Author	Michael Hoffmeister
Author	Hermann Brenner
Author	Iva Kirac
Author	Petar Matošević
Author	Philipp Hofer
Author	Stefanie Brezina
Author	Andrea Gsur
Author	Jeremy P. Cheadle
Author	Lauri A. Aaltonen
Author	Ian Tomlinson
Author	Richard S. Houlston
Author	Malcolm G. Dunlop
Author's institution	University of Zagreb School of Medicine
Scientific / art field, discipline and subdiscipline	BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences
Abstract (english)	Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide, and has a strong heritable basis. We report a genome-wide association analysis of 34,627 CRC cases and 71,379 controls of European ancestry that identifies SNPs at 31 new CRC risk loci. We also identify eight independent risk SNPs at the new and previously reported European CRC loci, and a further nine CRC SNPs at loci previously only identified in Asian populations. We use in situ promoter capture Hi-C (CHi-C), gene expression, and in silico annotation methods to identify likely target genes of CRC SNPs. Whilst these new SNP associations implicate target genes that are enriched for known CRC pathways such as Wnt and BMP, they also highlight novel pathways with no prior links to colorectal tumourigenesis. These findings provide further insight into CRC susceptibility and enhance the prospects of applying genetic risk scores to personalised screening and prevention.
Keywords (english)
Language	english
Publication type	Scientific paper - Original scientific paper
Publication status	Published
Peer review	Peer review
Publication version	Published version
Journal title	Nature Communications
Numbering	vol. 10, no. 1
p-ISSN	2041-1723
DOI	https://doi.org/10.1038/s41467-019-09775-w
URN:NBN	urn:nbn:hr:105:887802
Publication	2019-05-14
Document URL	http://doi.org/10.1038/s41467-019-09775-w
Type of resource	Text
Access conditions	Open access
Terms of use
Created on	2024-03-28 10:35:14