prikaz prve stranice dokumenta Development of the fetal neural retina in vitro and in ectopic transplants in vivo
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Scientific paper - Original scientific paper
Development of the fetal neural retina in vitro and in ectopic transplants in vivo
Collegium Antropologicum, 32 (2008), 1; 201-207. urn:nbn:hr:105:145971
Katušić, Ana; Jurić-Lekić, Gordana; Jovanov-Milošević, Nataša; Vlahović, Maja; Ježek, Davor; Šerman, Ljiljana; Sinčić, Nino; Veljanovska, Biljana; Bulić-Jakuš, Floriana

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Katušić, A., Jurić Lekić, G., Jovanov Milošević, N., Vlahović, M., Ježek, D., Šerman, Lj. ... Bulić Jakuš, F. (2008). Development of the fetal neural retina in vitro and in ectopic transplants in vivo. Collegium Antropologicum, 32. (1), 201-207. Retrieved from https://urn.nsk.hr/urn:nbn:hr:105:145971

Katušić, Ana, et al. "Development of the fetal neural retina in vitro and in ectopic transplants in vivo." Collegium Antropologicum, vol. 32, no. 1, 2008, pp. 201-207. https://urn.nsk.hr/urn:nbn:hr:105:145971

Katušić, Ana, Gordana Jurić Lekić, Nataša Jovanov Milošević, Maja Vlahović, Davor Ježek, Ljiljana Šerman, Nino Sinčić, Biljana Veljanovska and Floriana Bulić Jakuš. "Development of the fetal neural retina in vitro and in ectopic transplants in vivo." Collegium Antropologicum 32, no. 1 (2008): 201-207. https://urn.nsk.hr/urn:nbn:hr:105:145971

Katušić, A., et al. (2008) 'Development of the fetal neural retina in vitro and in ectopic transplants in vivo', Collegium Antropologicum, 32(1), pp. 201-207. Available at: https://urn.nsk.hr/urn:nbn:hr:105:145971 (Accessed 16 March 2025)

Katušić A, Jurić Lekić G, Jovanov Milošević N, Vlahović M, Ježek D, Šerman Lj, and sur.. Development of the fetal neural retina in vitro and in ectopic transplants in vivo. Collegium Antropologicum [Internet]. 2008 March [cited 2025 March 16];32(1):201-207. Available at: https://urn.nsk.hr/urn:nbn:hr:105:145971

A. Katušić, et al., "Development of the fetal neural retina in vitro and in ectopic transplants in vivo", Collegium Antropologicum, vol. 32, no. 1, pp. 201-207, March 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:145971. [Accessed: 16 March 2025]

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Title (english)Development of the fetal neural retina in vitro and in ectopic transplants in vivo
AuthorAna Katušić
AuthorGordana Jurić-Lekić
AuthorNataša Jovanov-Milošević
AuthorMaja Vlahović
AuthorDavor Ježek
AuthorLjiljana Šerman
AuthorNino Sinčić
AuthorBiljana Veljanovska
AuthorFloriana Bulić-Jakuš
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Investigation of the developmental potential of immature tissues is important for novel approaches to human regenerative medicine. Development of the fetal neural retina has therefore been investigated in two experimental systems. Retinas were microsurgically isolated from 20-days-old rat fetuses and cultivated in vitro for 12 days or transplanted in vivo under the kidney capsule of adult males for as long as 6 months. Shedding of the photoreceptor outer segment which is a process occurring at the terminal stage of photoreceptor differentiation was observed in culture by transmission electron microscopy (TEM). In transplants, no photoreceptors were found although markers of terminal neural and glial differentiation (e,g. synaptophysin, chromogranin and glial fibrilary acidic protein--GFAP) along with the molecules involved in the process of differentiation (guidance molecule semaphorin IIIA and chondroitin sulfate proteoglycan) were expressed. Semaphorin was differentially expressed being absent from older transplants. Proliferating cell nuclear antigen and nestin (marker of undifferentiated neural cells) were still weakly expressed even in six-months-old transplants. We could conclude that in both our experimental systems fetal neural retina proceeded to differentiate further on. However, even in long-term ectopic transplants a small population of cells still retained the potential for proliferation and has not yet reached the stage of terminal differentiation.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium Antropologicum
Numberingvol. 32, no. 1, pp. 201-207
p-ISSN0350-6134
URN:NBNurn:nbn:hr:105:145971
Publication2008-03
Document URLhttps://hrcak.srce.hr/23728
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 10:44:49