Estrogen and progesterone receptor status in primary breast cancer: a study of 11,273 patients from the year 1990 to 2002

Scientific paper - Original scientific paper

• Author: Damir Vrbanec
• Author: Branka Petričević
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

The aim of this study was to gain insight of the breast cancer hormone receptor status of our patients, its stratification according to age as well as its changes during the period of 13 years. 11,273 patients with primary breast cancer from several towns in Croatia were included in this study. Patients' tumour specimens were collected from 1990 to 2002 and were analysed on estrogen (ER) and progesterone (PR) receptors in the Laboratory of the Department of Medical Oncology, University Hospital Centre Zagreb. More than half of our breast cancer patients had ER positive tumours (54.3%). We observed ER + tumours increased with age continuously, with highest percentage in the age group of 70 to 79 years (68.1%). Similarly, proportion of PR + tumours was higher in the older age groups, being the highest between 40 and 49 years (55.9%). During 13 years of the study, the increase in frequency and proportion of ER + tumours was observed (from 52% in 1990 to 62% in 2002) and decrease of PR + tumours (56% to 53%). We confirm previous findings that the risk of hormone dependent breast cancer increases with aging. Risk of ER + breast cancer increased for 10% from 1990 to 2002 and PR + tumours decreased for 3.5% in the same period.

Abstract (croatian)

Cilj ovog rada je istražiti status hormonskih receptora karcinoma dojke kod naših pacijentica, stratificirati ih prema dobi, te utvrditi mijenja li se status receptora tijekom 13 godina praćenja pacijentica. U istraživanje je bilo uključeno 11 273 pacijentica s primarnim karcinomom dojke, iz nekoliko gradova Hrvatske. Uzorci tumora prikupljani su od 1990. do 2002. godine, te je učinjena analiza statusa estrogenskih i progesteronskih receptora u Laboratoriju Zavoda za patofiziologiju, Kliničkog bolničkog centra Zagreb. Većina pacijentica imala je pozitivne estrogenske receptore u tumoru (54,3%). Uočili smo kontinuirani porast učestalosti estrogen pozitivnih tumora s dobi, s najvišom učestalosti u dobnoj skupini od 70 do 79 godina (68,1%). Slično, udio progesteron pozitivnih tumora raste s dobi, te je najviši između 40 i 49 godina (55,9%). Tijekom 13 godina istraživanja, uočen je porast broja i postotka estrogen pozitivnih tumora (s 52% 1990.g. na 62% 2002.g.) te smanjenje progesteron pozitivnih tumora (s 56% na 53%). Ovim istraživanjem potvrđeni su rezultati ranijih studija kojima je utvrđen porast hormon ovisnih tumora s dobi. Rizik estrogen pozitivnih karcinoma dojke porastao je od 1990.g. do 2002.g. za 10%, dok se rizik progesteron pozitivnih smanjio za 3,5%.

• Keywords (english): Breast Neoplasms - epidemiology - metabolism; Receptors, Estrogen - metabolism; Receptors, Progesterone - metabolism; Adult; Age Distribution; Aged; Aged, 80 and over; Croatia - epidemiology; Female; Humans; Middle Aged; Risk Factors
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Collegium Antropologicum
• Numbering: vol. 31, no. 2, pp. 535-540
• p-ISSN: 0350-6134
• URN:NBN: urn:nbn:hr:105:956718
• Publication: 2007-06
• Document URL: https://hrcak.srce.hr/27411
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 10:55:11