Seroprevalence of herpes simplex virus type 2 in adult HIV-infected patients and blood donors in Croatia

Scientific paper - Original scientific paper

• Author: Oktavija Đaković Rode
• Author: Snježana Židovec Lepej
• Author: Josip Begovac
• Author's institution: University of Zagreb; School of Medicine
• Scientific / art field, discipline and subdiscipline: BIOMEDICINE AND HEALTHCARE; Clinical Medical Sciences

Abstract (english)

The present study estimates herpes simplex virus type 2 (HSV-2) seroprevalence and evaluates its association with age, sex, human herpesvirus type 8 (HHV-8) and human immunodeficiency virus (HIV) among adults in Croatia. A cross-sectional survey included 166 HIV-infected patients and 219 blood donors. Antibodies against HSV-2 were determined by enzyme immunoassays based on gG2 recombinant glycoprotein. HSV-2 seroprevalence was 45.8% in HIV-infected patients and 8.7% in blood donors (p < 0.0001; OR 8.8; 95% CI 5.05-15.49). Independent predictors of HSV-2 seropositivity were HIV infection (OR 11.0; 95% CI 5.93-20.41), female gender (OR 2.28; 95% CI 1.22-4.26), older age (OR 3.93; 95% CI 2.74-7.11), and HHV-8 seropositivity (OR 2.72; 95% CI 1.09-6.75). Understanding the epidemiology of HSV-2 is a critical first step in designing interventions to decrease HSV-2 and HIV transmission. The association of HSV-2 with HIV infection and HHV-8 antibodies suggests a similar transmission route.

Abstract (croatian)

Prikazani su rezultati istraživanja seroprevalencije virusa herpes simplex tipa 2 (HSV-2) u odraslih osoba u Hrvatskoj te povezanost HSV-2 s dobi, spolom, humanim herpesvirusom tipa 8 (HHV-8) i virusom humane imunodeficijencije (HIV). U presječnu studiju je uključeno 166 HIV-inficiranih pacijenata i 219 dobrovoljnih darovatelja krvi. Protutijela na HSV-2 su određena imunoenzimskim testom koji se temeljio na gG2 rekombinantnim glikoproteinima. Seroprevalencija HSV-2 u HIV-inficiranih pacijenata bila je 45,8%, a u dobrovoljnih darovatelja krvi 8,7% (p<0.0001; OR 8,8; 95% CI 5,05–15,49). Nezavisni prediktori za HSV-2 bili su HIV-infekcija (OR 11,0; 95% CI 5,93–20,41), ženski spol (OR 2,28; 95% CI 1,22–4,26), starija dob (OR 3,93; 95% CI 2,74–7,11) i seropozitivnost HHV-8 (OR 2,72; 95% CI 1,09–6,75). Poznavanje epidemiologije HSV-2 je prvi korak u kreiranju mjera za smanjivanje prijenosa HSV-2 i HIV-a. Povezanost HSV-2 s HIV-infekcijom i protutijelima na HHV-8 upućuje na sličan put prijenosa.

• Keywords (english): Blood Donors; HIV Infections; Herpes Genitalis - epidemiology - transmission; Adult; Aged; Antibodies, Viral - blood; Croatia - epidemiology; Cross-Sectional Studies; Female; Herpesviridae Infections - epidemiology - transmission; Herpesvirus 2, Human - immunology; Herpesvirus 8, Human - immunology; Humans; Male; Middle Aged; Seroepidemiologic Studies; Young Adult
• Language: english
• Publication type: Scientific paper - Original scientific paper
• Publication status: Published
• Peer review: Peer review
• Publication version: Published version
• Journal title: Collegium Antropologicum
• Numbering: vol. 32, no. 3, pp. 693-695
• p-ISSN: 0350-6134
• URN:NBN: urn:nbn:hr:105:235731
• Publication: 2008-09
• Document URL: https://hrcak.srce.hr/27043
• Type of resource: Text
• Access conditions: Open access
• Created on: 2024-03-28 11:07:32