prikaz prve stranice dokumenta Genome-wide association study of anthropometric traits in Korcula Island, Croatia
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Scientific paper - Original scientific paper
Genome-wide association study of anthropometric traits in Korcula Island, Croatia
Croatian Medical Journal, 50 (2009), 1; 7-16. https://doi.org/10.3325/cmj.2009.50.7
Polašek, Ozren; Marušić, Ana; Rotim, Krešimir; Hayward, Caroline; Vitart, Veronique; Huffman, Jennifer; Campbell, Susan; Janković, Stipan; Boban, Mladen; Biloglav, Zrinka; Kolčić, Ivana; Krželj, Vjekoslav; Terzić, Janoš; Matec, Lana; Tometić, Gordan; Nonković, Dijana; Ninčević, Jasna; Pehlić, Marina; Žedelj, Jurica; Velagić, Vedran; Juričić, Danica; Kirac, Iva; Belak Kovačević, Sanja; Wright, Alan F.; Campbell, Harry; Rudan, Igor More authors...

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Polašek, O., Marušić, A., Rotim, K., Hayward, C., Vitart, V., Huffman, J. ... Rudan, I. (2009). Genome-wide association study of anthropometric traits in Korcula Island, Croatia. Croatian Medical Journal, 50. (1), 7-16. doi: 10.3325/cmj.2009.50.7

Polašek, Ozren, et al. "Genome-wide association study of anthropometric traits in Korcula Island, Croatia." Croatian Medical Journal, vol. 50, no. 1, 2009, pp. 7-16. https://doi.org/10.3325/cmj.2009.50.7

Polašek, Ozren, Ana Marušić, Krešimir Rotim, Caroline Hayward, Veronique Vitart, Jennifer Huffman, Susan Campbell, et al. "Genome-wide association study of anthropometric traits in Korcula Island, Croatia." Croatian Medical Journal 50, no. 1 (2009): 7-16. https://doi.org/10.3325/cmj.2009.50.7

Polašek, O., et al. (2009) 'Genome-wide association study of anthropometric traits in Korcula Island, Croatia', Croatian Medical Journal, 50(1), pp. 7-16. doi: 10.3325/cmj.2009.50.7

Polašek O, Marušić A, Rotim K, Hayward C, Vitart V, Huffman J, and sur.. Genome-wide association study of anthropometric traits in Korcula Island, Croatia. Croatian Medical Journal [Internet]. 2009 February [cited 2024 December 01];50(1):7-16. doi: 10.3325/cmj.2009.50.7

O. Polašek, et al., "Genome-wide association study of anthropometric traits in Korcula Island, Croatia", Croatian Medical Journal, vol. 50, no. 1, pp. 7-16, February 2009. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:861112. [Accessed: 01 December 2024]

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Metadata
Title (english)Genome-wide association study of anthropometric traits in Korcula Island, Croatia
AuthorOzren Polašek
AuthorAna Marušić
AuthorKrešimir Rotim
AuthorCaroline Hayward
AuthorVeronique Vitart
AuthorJennifer Huffman
AuthorSusan Campbell
AuthorStipan Janković
AuthorMladen Boban
AuthorZrinka Biloglav
AuthorIvana Kolčić
AuthorVjekoslav Krželj
AuthorJanoš Terzić
AuthorLana Matec
AuthorGordan Tometić
AuthorDijana Nonković
AuthorJasna Ninčević
AuthorMarina Pehlić
AuthorJurica Žedelj
AuthorVedran Velagić
AuthorDanica Juričić
AuthorIva Kirac
AuthorSanja Belak Kovačević
AuthorAlan F. Wright
AuthorHarry Campbell
AuthorIgor Rudan
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Public Health and Health Care
Abstract (english)
AIM: To identify genetic variants underlying six anthropometric traits: body height, body weight, body mass index, brachial circumference, waist circumference, and hip circumference, using a genome-wide association study. ----- METHODS: The study was carried out in the isolated population of the island of Korcula, Croatia, with 898 adult examinees who participated in the larger DNA-based genetic epidemiological study in 2007. Anthropometric measurements followed standard internationally accepted procedures. Examinees were genotyped using HumanHap 370CNV chip by Illumina, with a genome-wide scan containing 316730 single nucleotide polymorphisms (SNP). ----- RESULTS: A total of 11 SNPs were associated with the investigated traits at the level of P<10(-5), with one SNP (rs7792939 in gene zinc finger protein 498, ZNF498) associated with body weight, hip circumference, and brachial circumference (P=3.59-5.73 x 10(-6)), and another one (rs157350 in gene delta-sarcoglycan, SGCD) with both brachial and hip circumference (P=3.70-6.08 x 10(-6). Variants in CRIM1, a gene regulating delivery of bone morphogenetic proteins to the cell surface, and ITGA1, involved in the regulation of mesenchymal stem cell proliferation and cartilage production, were also associated with brachial circumference (P=7.82 and 9.68 x 10(-6), respectively) and represent interesting functional candidates. Other associations involved those between genes SEZ6L2 and MAX and waist circumference, XTP6 and brachial circumference, and AMPA1/GRIA1 and height. ----- CONCLUSION: Although the study was underpowered for the reported associations to reach formal threshold of genome-wide significance under the assumption of independent multiple testing, the consistency of association between the 2 variants and a set of anthropometric traits makes CRIM1 and ITGA1 highly interesting for further replication and functional follow-up. Increased linkage disequilibrium between the used markers in an isolated population makes the formal significance threshold overly stringent, and changed allele frequencies in isolate population may contribute to identifying variants that would not be easily identified in large outbred populations.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCroatian Medical Journal
Numberingvol. 50, no. 1, pp. 7-16
p-ISSN0353-9504
DOIhttps://doi.org/10.3325/cmj.2009.50.7
URN:NBNurn:nbn:hr:105:861112
Publication2009-02
Document URLhttp://www.cmj.hr/2009/50/1/19260139.htm
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:14:13