prikaz prve stranice dokumenta Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors
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Scientific paper - Original scientific paper
Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors
Pathology, Research and Practice, 206 (2010), 3; 163-167. https://doi.org/10.1016/j.prp.2009.10.007
Vladušić, Tomislav; Hrašćan, Reno; Vrhovac, Ivana; Krušlin, Božo; Gamulin, Marija; Grgić, Mislav; Pećina-Šlaus, Nives; Franekić Čolić, Jasna

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Vladušić, T., Hrašćan, R., Vrhovac, I., Krušlin, B., Gamulin, M., Grgić, M. ... Franekić Čolić, J. (2010). Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors. Pathology, Research and Practice, 206. (3), 163-167. doi: 10.1016/j.prp.2009.10.007

Vladušić, Tomislav, et al. "Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors." Pathology, Research and Practice, vol. 206, no. 3, 2010, pp. 163-167. https://doi.org/10.1016/j.prp.2009.10.007

Vladušić, Tomislav, Reno Hrašćan, Ivana Vrhovac, Božo Krušlin, Marija Gamulin, Mislav Grgić, Nives Pećina Šlaus and Jasna Franekić Čolić. "Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors." Pathology, Research and Practice 206, no. 3 (2010): 163-167. https://doi.org/10.1016/j.prp.2009.10.007

Vladušić, T., et al. (2010) 'Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors', Pathology, Research and Practice, 206(3), pp. 163-167. doi: 10.1016/j.prp.2009.10.007

Vladušić T, Hrašćan R, Vrhovac I, Krušlin B, Gamulin M, Grgić M, and sur.. Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors. Pathology, Research and Practice [Internet]. 2010 March 15 [cited 2024 December 21];206(3):163-167. doi: 10.1016/j.prp.2009.10.007

T. Vladušić, et al., "Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors", Pathology, Research and Practice, vol. 206, no. 3, pp. 163-167, March 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:105:156165. [Accessed: 21 December 2024]

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Metadata
Title (english)Loss of heterozygosity of selected tumor suppressor genes in human testicular germ cell tumors
AuthorTomislav Vladušić
AuthorReno Hrašćan
AuthorIvana Vrhovac
AuthorBožo Krušlin
AuthorMarija Gamulin
AuthorMislav Grgić
AuthorNives Pećina-Šlaus
AuthorJasna Franekić Čolić
Author's institutionUniversity of Zagreb
School of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Human testicular germ cell tumors (TGCTs) are histologically heterogenous neoplasms with a variable malignant potential. Two main groups of germ cell tumors occur in men: seminomas and nonseminomas. In the present study, a set of four tumor suppressor genes was investigated in testicular cancers. CDH1, APC, p53, and nm23-H1 genes were tested for loss of heterozygosity (LOH). Thirty-eight testicular germ cell tumors (17 seminomas and 21 nonseminomas) were analyzed by PCR using restriction fragment length polymorphism or the dinucleotide/tetranucleotide repeat polymorphism method. An allelic loss of p53 at exon 4 was detected in five nonseminomas, whereas LOH of p53 at intron 6 occurred in one of the seminoma and two of the nonseminoma samples. Allelic losses of the APC gene were present in three seminomas and one nonseminoma, whereas one seminoma and three nonseminomas showed LOH of CDH1. The analysis of allelic losses showed no common structural genetic alterations in tumor tissues, although a different pattern of LOH was observed between the two main histological groups of TGCTs.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionAccepted version
Journal titlePathology, Research and Practice
Numberingvol. 206, no. 3, pp. 163-167
p-ISSN0344-0338
DOIhttps://doi.org/10.1016/j.prp.2009.10.007
URN:NBNurn:nbn:hr:105:156165
Publication2010-03-15
Document URLhttps://doi.org/10.1016/j.prp.2009.10.007
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2024-03-28 11:29:19